Evaluation of Pharmacokinetic and Pharmacodynamic Profiles and Tolerability After Single (2.5, 5, or 10 mg) and Repeated (2.5, 5, or 10 mg BID for 4.5 days) Oral Administration of Ivabradine in Healthy Male Korean Volunteers

Abstract Background Ivabradine, a selective inhibitor of the pacemaker current in the sinoatrial node, has shown pure heart rate (HR)-reducing effects with anti-ischemic efficacy as well as improvement in heart failure outcomes. Objective The purpose of this study was to explore pharmacokinetic (PK)...

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Veröffentlicht in:	Clinical therapeutics 2013-06, Vol.35 (6), p.819-835
Hauptverfasser:	Choi, Hee Youn, MD, Noh, Yook-Hwan, MD, Cho, Sang-Heon, MD, PhD, Ghim, Jong-Lyul, MD, PhD, Choe, Sangmin, MD, PhD, Kim, Un-Jib, MD, Ah Jung, Jin, MD, PhD, Bae, Kyun-Seop, MD, PhD, Lim, Hyeong-Seok, MD, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Adolescent Adult Asian Continental Ancestry Group Benzazepines - administration & dosage Benzazepines - pharmacokinetics Biological and medical sciences Cardiovascular disease Double-Blind Method Drug Administration Schedule Drug dosages Drug therapy Drug Tolerance Family medical history healthy individual Heart failure Heart rate Heart Rate - drug effects Humans Internal Medicine ivabradine Laboratories Male Medical Education Medical sciences Mortality pharmacodynamics pharmacokinetics Pharmacology. Drug treatments Studies Volunteers Young Adult
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