T helper 17 polarization in familial Mediterranean fever

Autoinflammatory attacks in familial Mediterranean fever (FMF) are accompanied by elevated levels of interleukin-6 (IL-6), and are controllable by IL-1-targeting drugs. In combination, IL-6 and IL-1 are known to be potent inducers of T helper (Th) 17 cells development. Therefore, we studied the Th17...

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Veröffentlicht in:	Genes and immunity 2013-06, Vol.14 (4), p.212-216
Hauptverfasser:	Ovadia, A, Livneh, A, Feld, O, Ben-Zvi, I, Kukuy, E, Kivity, S, Lidar, M, Barda-Saad, M, Shinar, Y
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208/2489/144 631/250/127/1213 631/250/1619/554/1898/1273 692/699/249/2510/2511 Adolescent Adult Biomarkers Biomedical and Life Sciences Biomedicine Cancer Research Case-Control Studies CD4 antigen Cell culture Cells, Cultured Cytokines Cytoskeletal Proteins - genetics Development and progression Drug delivery Familial Mediterranean fever Familial Mediterranean Fever - genetics Familial Mediterranean Fever - immunology Familial Mediterranean Fever - metabolism Female Fever Forkhead Transcription Factors - genetics Forkhead Transcription Factors - metabolism Foxp3 protein GATA-3 protein GATA3 Transcription Factor - genetics GATA3 Transcription Factor - metabolism Gene Expression Genes Genetic aspects Genotype & phenotype Genotypes Helper cells Human Genetics Humans Immune response Immunology Interleukin 1 Interleukin 17 Interleukin 6 Interleukin-17 - genetics Interleukin-17 - metabolism Leukocytes (mononuclear) Lymphocyte Activation Lymphocytes T Male Medical research Middle Aged Nuclear Receptor Subfamily 1, Group F, Member 1 - genetics Nuclear Receptor Subfamily 1, Group F, Member 1 - metabolism original-article Peripheral blood mononuclear cells Physiological aspects Population studies Producer cells Pyrin Pyrin protein Remission Remission (Medicine) Retinoic acid T cell receptors T cells T-Lymphocytes, Regulatory - metabolism Th17 Cells - immunology Th17 Cells - metabolism Transcription factors Transcription, Genetic
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