Multiple sclerosis susceptibility loci do not alter clinical and MRI outcomes in clinically isolated syndrome

It has not yet been established whether genetic predictors of multiple sclerosis (MS) susceptibility also influence disease severity and accumulation of disability. Our aim was to evaluate associations between 16 previously validated genetic susceptibility markers and MS phenotype. Patients with cli...

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Veröffentlicht in:	Genes and immunity 2013-06, Vol.14 (4), p.244-248
Hauptverfasser:	Kalincik, T, Guttmann, C R G, Krasensky, J, Vaneckova, M, Lelkova, P, Tyblova, M, Seidl, Z, De Jager, P L, Havrdova, E, Horakova, D
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208/727/2000 692/699/249/1313/1666 692/700/1421/1628 692/700/1750 Adolescent Adult Biological response modifiers Biomarkers - cerebrospinal fluid Biomedical and Life Sciences Biomedicine Brain Brain - pathology Cancer Research Cerebrospinal fluid Corpus callosum Development and progression Female Gene Expression Genes Genetic aspects Genetic Association Studies Genetic Loci Genetic Predisposition to Disease Genotype & phenotype Health aspects Health risk assessment Hospitals Human Genetics Humans Immunology Magnetic Resonance Imaging Male Medicine Middle Aged Multiple sclerosis Multiple Sclerosis - diagnosis Multiple Sclerosis - genetics Neuroimaging Neurology original-article Phenotype Phenotypes Polymorphism Polymorphism, Single Nucleotide Risk factors Single nucleotide polymorphisms Single-nucleotide polymorphism Substantia alba Substantia grisea Susceptibility β-Interferon
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