Adolescence fluoxetine increases serotonergic activity in the raphe-hippocampus axis and improves depression-like behaviors in female rats that experienced neonatal maternal separation

Summary This study was conducted to examine if fluoxetine, a selective 5-hydroxytryptamine (5-HT) reuptake inhibitor, would reverse adverse behavioral effects of neonatal maternal separation in female rats. Sprague–Dawley pups were separated from dam daily for 3 h during postnatal day (PND) 1–14 (ma...

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Veröffentlicht in:	Psychoneuroendocrinology 2013-06, Vol.38 (6), p.777-788
Hauptverfasser:	Yoo, Sang Bae, Kim, Bom-Taeck, Kim, Jin Young, Ryu, Vitaly, Kang, Dong-Won, Lee, Jong-Ho, Jahng, Jeong Won
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult and adolescent clinical studies Animals Animals, Newborn Behavior, Animal - drug effects Behavioral psychophysiology Biological and medical sciences Body Weight - drug effects Corticosterone - blood Corticotropin-Releasing Hormone - biosynthesis Depression Depression - drug therapy Eating - drug effects Eating disorders Endocrinology & Metabolism Feeding and Eating Disorders - drug therapy Feeding and Eating Disorders - metabolism Female Fluoxetine - pharmacology Fluoxetine - therapeutic use Food intake Fundamental and applied biological sciences. Psychology Hippocampus - drug effects Hippocampus - metabolism Hormones and behavior Hypothalamus - drug effects Hypothalamus - metabolism Maternal Deprivation Medical sciences Mood disorders Neonatal maternal separation Neuropharmacology Pharmacology. Drug treatments Psychiatry Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Psychopathology. Psychiatry Psychopharmacology Raphe Nuclei - drug effects Raphe Nuclei - metabolism Rats Serotonergic Neurons - drug effects Serotonergic Neurons - metabolism Serotonin Serotonin - metabolism Serotonin Plasma Membrane Transport Proteins - biosynthesis Serotonin Uptake Inhibitors - pharmacology Serotonin Uptake Inhibitors - therapeutic use Stress
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