A whole blood assay as a simple, broad assessment of cytokines and chemokines to evaluate human immune responses to Mycobacterium tuberculosis antigens

Whole-blood assays (WBA) are well-suited low-cost proxy-measures while keeping the physiological environment during search for 11 out of 16 serum biomarkers (scheme) after in vitro stimulation with specific tuberculosis antigens. •Broader assessment of biosignature profiles can be accurately, fast a...

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Veröffentlicht in:	Acta tropica 2013-08, Vol.127 (2), p.75-81
Hauptverfasser:	Silva, Dolores, Ponte, Carlos G.G., Hacker, Mariana A., Antas, Paulo R.Z.
Format:	Artikel
Sprache:	eng
Schlagworte:	antigens Antigens, Bacterial - immunology biomarkers blood serum Cellularity Chemokines Chemokines - genetics Chemokines - metabolism Cytokines Cytokines - genetics Cytokines - metabolism flow cytometry Gene Expression Regulation - immunology granulocyte-macrophage colony-stimulating factor Humans immune response interferon-gamma interleukin-10 interleukin-13 interleukin-1beta interleukin-2 interleukin-4 interleukin-5 interleukin-6 interleukin-7 interleukin-8 M. tuberculosis mononuclear leukocytes Mycobacterium bovis Mycobacterium tuberculosis Mycobacterium tuberculosis - immunology Mycobacterium tuberculosis - metabolism Serum biomarkers Tuberculosis Tuberculosis, Pulmonary - blood Tuberculosis, Pulmonary - diagnosis tumor necrosis factor-alpha Whole blood assays
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