The assessment of primitive or metastatic malignant pulmonary tumors in children
The purpose of our study is to assess primitive and secondary malignant pulmonary tumors in children. The presence of lung tumors in newborns and infants is a point of interest to specialists in pediatric surgery, thoracic surgery and genetics due to the high death rate. The 5-years survival rate co...
Gespeichert in:
Veröffentlicht in: | Chirurgia (Bucharest, Romania : 1990) Romania : 1990), 2013-05, Vol.108 (3), p.351-359 |
---|---|
Hauptverfasser: | , , , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 359 |
---|---|
container_issue | 3 |
container_start_page | 351 |
container_title | Chirurgia (Bucharest, Romania : 1990) |
container_volume | 108 |
creator | Burnei, Gh Draghici, I Gavriliu, St Georgescu, I Burnei, A Vlad, C El Nayef, T Draghici, L |
description | The purpose of our study is to assess primitive and secondary malignant pulmonary tumors in children. The presence of lung tumors in newborns and infants is a point of interest to specialists in pediatric surgery, thoracic surgery and genetics due to the high death rate. The 5-years survival rate communicated by EUROCARE-study is less than 10% for primitive tumors and less than 15% in lung metastases.
We performed a retrospective study which analysed 11 children with pulmonary primary ormetastatic tumors admitted in the Pediatric Surgery Department “Prof. Dr. Al. Pesamosca” of the Emergency Clinical Hospital for Children “Maria Sklodowska Curie”,Bucharest. The analysed and operated patients underwent surgery by Prof. Dr. Al. Pesamosca and the authors during the period of 1985-2011. In our series there where 4 primitive lung tumors and 7 secondary ones: 8 underwent surgery and 2 died before being operated on. The incidence of primitive pulmonary lung malignancies is higher for females, 3 to1, and secondary ones are more frequent in males, 6 to 1.
Patients with primitive pulmonary malignancies were late diagnosed. Their age ranged between 1 to 6 years;3 were operated on, out of which 2 died, and 1 operated still survives. The 7 patients with secondary pulmonary malignancies were late diagnosed, too, probably as a consequence of a late diagnosis of the origin tumor.
Even if all malignancies require an early diagnosis and treatment, this aim regarding malignant lung tumors is still a desideratum animating all practitioners. Primitive tumors are diagnosed presenting the main clinical manifestation abroncho pulmonary infection. Secondary lung malignancies are usually asymptomatic and are diagnosed when monitoring a patient for a malignancy with another origin. Chemotherapy,radiotherapy and surgery of malignant primitive tumors or metastatic ones in children remain unsatisfactory because of the late diagnosis and the limited methods of treatment. Nowadays genetics identified the responsible oncogenes for pulmonary blastic explosion and better results could be obtained by genetic surgery. |
format | Article |
fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_1371271098</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1371271098</sourcerecordid><originalsourceid>FETCH-LOGICAL-p211t-7cef1813675f25f8fc22dfea27491534b7bc3ea5201026cd63b0095c7597b473</originalsourceid><addsrcrecordid>eNo1kE1LxDAYhHNQ3GXdvyA5einkTZqmPcriFyysh95Lmr5xI0lbk1Tw31txnctcHoaZuSJb4ByKBqDekH1KH2xVxThj4oZsuFANU3W5JW_tGalOCVMKOGY6WTpHF1x2X0inSANmnbLOztCgvXsf9QrNiw_TqOM3zUuYYqJupObs_BBxvCXXVvuE-4vvSPv02B5eiuPp-fXwcCxmDpALZdBCDaJS0nJpa2s4HyxqrsoGpCh71RuBWnIGjFdmqETPWCONko3qSyV25P4vdo7T54Ipd8Elg97rEacldSAUcAWsqVf07oIufcCh-923du_-TxA_WPtYiQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1371271098</pqid></control><display><type>article</type><title>The assessment of primitive or metastatic malignant pulmonary tumors in children</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Burnei, Gh ; Draghici, I ; Gavriliu, St ; Georgescu, I ; Burnei, A ; Vlad, C ; El Nayef, T ; Draghici, L</creator><creatorcontrib>Burnei, Gh ; Draghici, I ; Gavriliu, St ; Georgescu, I ; Burnei, A ; Vlad, C ; El Nayef, T ; Draghici, L</creatorcontrib><description>The purpose of our study is to assess primitive and secondary malignant pulmonary tumors in children. The presence of lung tumors in newborns and infants is a point of interest to specialists in pediatric surgery, thoracic surgery and genetics due to the high death rate. The 5-years survival rate communicated by EUROCARE-study is less than 10% for primitive tumors and less than 15% in lung metastases.
We performed a retrospective study which analysed 11 children with pulmonary primary ormetastatic tumors admitted in the Pediatric Surgery Department “Prof. Dr. Al. Pesamosca” of the Emergency Clinical Hospital for Children “Maria Sklodowska Curie”,Bucharest. The analysed and operated patients underwent surgery by Prof. Dr. Al. Pesamosca and the authors during the period of 1985-2011. In our series there where 4 primitive lung tumors and 7 secondary ones: 8 underwent surgery and 2 died before being operated on. The incidence of primitive pulmonary lung malignancies is higher for females, 3 to1, and secondary ones are more frequent in males, 6 to 1.
Patients with primitive pulmonary malignancies were late diagnosed. Their age ranged between 1 to 6 years;3 were operated on, out of which 2 died, and 1 operated still survives. The 7 patients with secondary pulmonary malignancies were late diagnosed, too, probably as a consequence of a late diagnosis of the origin tumor.
Even if all malignancies require an early diagnosis and treatment, this aim regarding malignant lung tumors is still a desideratum animating all practitioners. Primitive tumors are diagnosed presenting the main clinical manifestation abroncho pulmonary infection. Secondary lung malignancies are usually asymptomatic and are diagnosed when monitoring a patient for a malignancy with another origin. Chemotherapy,radiotherapy and surgery of malignant primitive tumors or metastatic ones in children remain unsatisfactory because of the late diagnosis and the limited methods of treatment. Nowadays genetics identified the responsible oncogenes for pulmonary blastic explosion and better results could be obtained by genetic surgery.</description><identifier>ISSN: 1221-9118</identifier><identifier>PMID: 23790784</identifier><language>eng</language><publisher>Romania</publisher><subject>Adolescent ; Carcinoma - diagnosis ; Carcinoma - mortality ; Carcinoma - secondary ; Carcinoma - therapy ; Chemoradiotherapy, Adjuvant ; Child ; Child, Preschool ; Delayed Diagnosis ; Female ; Follow-Up Studies ; Hospitals, Pediatric ; Hospitals, University ; Humans ; Incidence ; Infant ; Lung Neoplasms - diagnosis ; Lung Neoplasms - mortality ; Lung Neoplasms - pathology ; Lung Neoplasms - therapy ; Male ; Neoplasm Staging ; Pneumonectomy ; Pulmonary Blastoma - diagnosis ; Pulmonary Blastoma - mortality ; Pulmonary Blastoma - secondary ; Pulmonary Blastoma - therapy ; Retrospective Studies ; Risk Assessment ; Romania - epidemiology ; Sarcoma - diagnosis ; Sarcoma - mortality ; Sarcoma - secondary ; Sarcoma - therapy ; Surgery Department, Hospital ; Survival Rate ; Treatment Outcome</subject><ispartof>Chirurgia (Bucharest, Romania : 1990), 2013-05, Vol.108 (3), p.351-359</ispartof><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23790784$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Burnei, Gh</creatorcontrib><creatorcontrib>Draghici, I</creatorcontrib><creatorcontrib>Gavriliu, St</creatorcontrib><creatorcontrib>Georgescu, I</creatorcontrib><creatorcontrib>Burnei, A</creatorcontrib><creatorcontrib>Vlad, C</creatorcontrib><creatorcontrib>El Nayef, T</creatorcontrib><creatorcontrib>Draghici, L</creatorcontrib><title>The assessment of primitive or metastatic malignant pulmonary tumors in children</title><title>Chirurgia (Bucharest, Romania : 1990)</title><addtitle>Chirurgia (Bucur)</addtitle><description>The purpose of our study is to assess primitive and secondary malignant pulmonary tumors in children. The presence of lung tumors in newborns and infants is a point of interest to specialists in pediatric surgery, thoracic surgery and genetics due to the high death rate. The 5-years survival rate communicated by EUROCARE-study is less than 10% for primitive tumors and less than 15% in lung metastases.
We performed a retrospective study which analysed 11 children with pulmonary primary ormetastatic tumors admitted in the Pediatric Surgery Department “Prof. Dr. Al. Pesamosca” of the Emergency Clinical Hospital for Children “Maria Sklodowska Curie”,Bucharest. The analysed and operated patients underwent surgery by Prof. Dr. Al. Pesamosca and the authors during the period of 1985-2011. In our series there where 4 primitive lung tumors and 7 secondary ones: 8 underwent surgery and 2 died before being operated on. The incidence of primitive pulmonary lung malignancies is higher for females, 3 to1, and secondary ones are more frequent in males, 6 to 1.
Patients with primitive pulmonary malignancies were late diagnosed. Their age ranged between 1 to 6 years;3 were operated on, out of which 2 died, and 1 operated still survives. The 7 patients with secondary pulmonary malignancies were late diagnosed, too, probably as a consequence of a late diagnosis of the origin tumor.
Even if all malignancies require an early diagnosis and treatment, this aim regarding malignant lung tumors is still a desideratum animating all practitioners. Primitive tumors are diagnosed presenting the main clinical manifestation abroncho pulmonary infection. Secondary lung malignancies are usually asymptomatic and are diagnosed when monitoring a patient for a malignancy with another origin. Chemotherapy,radiotherapy and surgery of malignant primitive tumors or metastatic ones in children remain unsatisfactory because of the late diagnosis and the limited methods of treatment. Nowadays genetics identified the responsible oncogenes for pulmonary blastic explosion and better results could be obtained by genetic surgery.</description><subject>Adolescent</subject><subject>Carcinoma - diagnosis</subject><subject>Carcinoma - mortality</subject><subject>Carcinoma - secondary</subject><subject>Carcinoma - therapy</subject><subject>Chemoradiotherapy, Adjuvant</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Delayed Diagnosis</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Hospitals, Pediatric</subject><subject>Hospitals, University</subject><subject>Humans</subject><subject>Incidence</subject><subject>Infant</subject><subject>Lung Neoplasms - diagnosis</subject><subject>Lung Neoplasms - mortality</subject><subject>Lung Neoplasms - pathology</subject><subject>Lung Neoplasms - therapy</subject><subject>Male</subject><subject>Neoplasm Staging</subject><subject>Pneumonectomy</subject><subject>Pulmonary Blastoma - diagnosis</subject><subject>Pulmonary Blastoma - mortality</subject><subject>Pulmonary Blastoma - secondary</subject><subject>Pulmonary Blastoma - therapy</subject><subject>Retrospective Studies</subject><subject>Risk Assessment</subject><subject>Romania - epidemiology</subject><subject>Sarcoma - diagnosis</subject><subject>Sarcoma - mortality</subject><subject>Sarcoma - secondary</subject><subject>Sarcoma - therapy</subject><subject>Surgery Department, Hospital</subject><subject>Survival Rate</subject><subject>Treatment Outcome</subject><issn>1221-9118</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kE1LxDAYhHNQ3GXdvyA5einkTZqmPcriFyysh95Lmr5xI0lbk1Tw31txnctcHoaZuSJb4ByKBqDekH1KH2xVxThj4oZsuFANU3W5JW_tGalOCVMKOGY6WTpHF1x2X0inSANmnbLOztCgvXsf9QrNiw_TqOM3zUuYYqJupObs_BBxvCXXVvuE-4vvSPv02B5eiuPp-fXwcCxmDpALZdBCDaJS0nJpa2s4HyxqrsoGpCh71RuBWnIGjFdmqETPWCONko3qSyV25P4vdo7T54Ipd8Elg97rEacldSAUcAWsqVf07oIufcCh-923du_-TxA_WPtYiQ</recordid><startdate>20130501</startdate><enddate>20130501</enddate><creator>Burnei, Gh</creator><creator>Draghici, I</creator><creator>Gavriliu, St</creator><creator>Georgescu, I</creator><creator>Burnei, A</creator><creator>Vlad, C</creator><creator>El Nayef, T</creator><creator>Draghici, L</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20130501</creationdate><title>The assessment of primitive or metastatic malignant pulmonary tumors in children</title><author>Burnei, Gh ; Draghici, I ; Gavriliu, St ; Georgescu, I ; Burnei, A ; Vlad, C ; El Nayef, T ; Draghici, L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p211t-7cef1813675f25f8fc22dfea27491534b7bc3ea5201026cd63b0095c7597b473</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adolescent</topic><topic>Carcinoma - diagnosis</topic><topic>Carcinoma - mortality</topic><topic>Carcinoma - secondary</topic><topic>Carcinoma - therapy</topic><topic>Chemoradiotherapy, Adjuvant</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Delayed Diagnosis</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Hospitals, Pediatric</topic><topic>Hospitals, University</topic><topic>Humans</topic><topic>Incidence</topic><topic>Infant</topic><topic>Lung Neoplasms - diagnosis</topic><topic>Lung Neoplasms - mortality</topic><topic>Lung Neoplasms - pathology</topic><topic>Lung Neoplasms - therapy</topic><topic>Male</topic><topic>Neoplasm Staging</topic><topic>Pneumonectomy</topic><topic>Pulmonary Blastoma - diagnosis</topic><topic>Pulmonary Blastoma - mortality</topic><topic>Pulmonary Blastoma - secondary</topic><topic>Pulmonary Blastoma - therapy</topic><topic>Retrospective Studies</topic><topic>Risk Assessment</topic><topic>Romania - epidemiology</topic><topic>Sarcoma - diagnosis</topic><topic>Sarcoma - mortality</topic><topic>Sarcoma - secondary</topic><topic>Sarcoma - therapy</topic><topic>Surgery Department, Hospital</topic><topic>Survival Rate</topic><topic>Treatment Outcome</topic><toplevel>online_resources</toplevel><creatorcontrib>Burnei, Gh</creatorcontrib><creatorcontrib>Draghici, I</creatorcontrib><creatorcontrib>Gavriliu, St</creatorcontrib><creatorcontrib>Georgescu, I</creatorcontrib><creatorcontrib>Burnei, A</creatorcontrib><creatorcontrib>Vlad, C</creatorcontrib><creatorcontrib>El Nayef, T</creatorcontrib><creatorcontrib>Draghici, L</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Chirurgia (Bucharest, Romania : 1990)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Burnei, Gh</au><au>Draghici, I</au><au>Gavriliu, St</au><au>Georgescu, I</au><au>Burnei, A</au><au>Vlad, C</au><au>El Nayef, T</au><au>Draghici, L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The assessment of primitive or metastatic malignant pulmonary tumors in children</atitle><jtitle>Chirurgia (Bucharest, Romania : 1990)</jtitle><addtitle>Chirurgia (Bucur)</addtitle><date>2013-05-01</date><risdate>2013</risdate><volume>108</volume><issue>3</issue><spage>351</spage><epage>359</epage><pages>351-359</pages><issn>1221-9118</issn><abstract>The purpose of our study is to assess primitive and secondary malignant pulmonary tumors in children. The presence of lung tumors in newborns and infants is a point of interest to specialists in pediatric surgery, thoracic surgery and genetics due to the high death rate. The 5-years survival rate communicated by EUROCARE-study is less than 10% for primitive tumors and less than 15% in lung metastases.
We performed a retrospective study which analysed 11 children with pulmonary primary ormetastatic tumors admitted in the Pediatric Surgery Department “Prof. Dr. Al. Pesamosca” of the Emergency Clinical Hospital for Children “Maria Sklodowska Curie”,Bucharest. The analysed and operated patients underwent surgery by Prof. Dr. Al. Pesamosca and the authors during the period of 1985-2011. In our series there where 4 primitive lung tumors and 7 secondary ones: 8 underwent surgery and 2 died before being operated on. The incidence of primitive pulmonary lung malignancies is higher for females, 3 to1, and secondary ones are more frequent in males, 6 to 1.
Patients with primitive pulmonary malignancies were late diagnosed. Their age ranged between 1 to 6 years;3 were operated on, out of which 2 died, and 1 operated still survives. The 7 patients with secondary pulmonary malignancies were late diagnosed, too, probably as a consequence of a late diagnosis of the origin tumor.
Even if all malignancies require an early diagnosis and treatment, this aim regarding malignant lung tumors is still a desideratum animating all practitioners. Primitive tumors are diagnosed presenting the main clinical manifestation abroncho pulmonary infection. Secondary lung malignancies are usually asymptomatic and are diagnosed when monitoring a patient for a malignancy with another origin. Chemotherapy,radiotherapy and surgery of malignant primitive tumors or metastatic ones in children remain unsatisfactory because of the late diagnosis and the limited methods of treatment. Nowadays genetics identified the responsible oncogenes for pulmonary blastic explosion and better results could be obtained by genetic surgery.</abstract><cop>Romania</cop><pmid>23790784</pmid><tpages>9</tpages></addata></record> |
fulltext | fulltext |
identifier | ISSN: 1221-9118 |
ispartof | Chirurgia (Bucharest, Romania : 1990), 2013-05, Vol.108 (3), p.351-359 |
issn | 1221-9118 |
language | eng |
recordid | cdi_proquest_miscellaneous_1371271098 |
source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
subjects | Adolescent Carcinoma - diagnosis Carcinoma - mortality Carcinoma - secondary Carcinoma - therapy Chemoradiotherapy, Adjuvant Child Child, Preschool Delayed Diagnosis Female Follow-Up Studies Hospitals, Pediatric Hospitals, University Humans Incidence Infant Lung Neoplasms - diagnosis Lung Neoplasms - mortality Lung Neoplasms - pathology Lung Neoplasms - therapy Male Neoplasm Staging Pneumonectomy Pulmonary Blastoma - diagnosis Pulmonary Blastoma - mortality Pulmonary Blastoma - secondary Pulmonary Blastoma - therapy Retrospective Studies Risk Assessment Romania - epidemiology Sarcoma - diagnosis Sarcoma - mortality Sarcoma - secondary Sarcoma - therapy Surgery Department, Hospital Survival Rate Treatment Outcome |
title | The assessment of primitive or metastatic malignant pulmonary tumors in children |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T13%3A50%3A24IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20assessment%20of%20primitive%20or%20metastatic%20malignant%20pulmonary%20tumors%20in%20children&rft.jtitle=Chirurgia%20(Bucharest,%20Romania%20:%201990)&rft.au=Burnei,%20Gh&rft.date=2013-05-01&rft.volume=108&rft.issue=3&rft.spage=351&rft.epage=359&rft.pages=351-359&rft.issn=1221-9118&rft_id=info:doi/&rft_dat=%3Cproquest_pubme%3E1371271098%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1371271098&rft_id=info:pmid/23790784&rfr_iscdi=true |