Phenotypic redifferentiation and cell cluster formation of cultured human articular chondrocytes in a three-dimensional oriented gelatin scaffold in the presence of PGE2 - first results of a pilot study

Modern tissue engineering strategies comprise three elemental parameters: cells, scaffolds and growth factors. Articular cartilage represents a highly specialized tissue which allows frictionless gliding of corresponding articulating surfaces. As the regenerative potential of cartilage is low, tissu...

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Veröffentlicht in:	Journal of biomedical materials research. Part A 2013-08, Vol.101A (8), p.2374-2382
Hauptverfasser:	Brochhausen, Christoph, Sánchez, Natalia, Halstenberg, Sven, Zehbe, Rolf, Watzer, Bernhard, Schmitt, Volker H., Hofmann, Alexander, Meurer, Andrea, Unger, Ron E., Kirkpatrick, Charles James
Format:	Artikel
Sprache:	eng
Schlagworte:	articular cartilage Biological and medical sciences Biotechnology Cartilage, Articular - cytology Cartilage, Articular - growth & development Cell Differentiation Cells, Cultured chondrocytes Chondrocytes - cytology Chondrocytes - metabolism Collagen Type I - genetics Collagen Type II - genetics Dinoprostone - administration & dosage Dinoprostone - metabolism Fundamental and applied biological sciences. Psychology Gelatin - chemistry Gene Expression Regulation Health. Pharmaceutical industry Humans Industrial applications and implications. Economical aspects Medical sciences Miscellaneous Pilot Projects prostaglandin scaffold Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Technology. Biomaterials. Equipments tissue engineering Tissue Engineering - methods Tissue Scaffolds - chemistry
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