A retinyl palmitate-loaded solid lipid nanoparticle system: Effect of surface modification with dicetyl phosphate on skin permeation in vitro and anti-wrinkle effect in vivo

Surface-modified solid lipid nanoparticles (SLNs) containing retinyl palmitate (Rpal) were prepared by the hot-melt method using Gelucire 50/13® and Precirol ATO5®. Dicetyl phosphate (DCP) was added to negatively charge the surfaces of the SLNs and thereby enhance the skin distribution properties of...

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Veröffentlicht in:	International journal of pharmaceutics 2013-08, Vol.452 (1-2), p.311-320
Hauptverfasser:	Jeon, Ho Seong, Seo, Jo Eun, Kim, Min Soo, Kang, Mean Hyung, Oh, Dong Ho, Jeon, Sang Ok, Seong Hoon Jeong, Choi, Young Wook, Lee, Sangkil
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrylic Resins - chemistry Animals Anti-wrinkle effect Antioxidants - administration & dosage Antioxidants - chemistry Antioxidants - pharmacokinetics Diacetyl - analogs & derivatives Diacetyl - chemistry Dicetyl phosphate Diglycerides - chemistry Drug Carriers - administration & dosage Drug Carriers - chemistry Drug Carriers - pharmacokinetics Fats - chemistry Female In Vitro Techniques Male Mice Mice, Hairless Nanoparticles - administration & dosage Nanoparticles - chemistry Oils - chemistry Organophosphorus Compounds - chemistry Particle Size Rats Rats, Sprague-Dawley Retinyl palmitate Skin - drug effects Skin - metabolism Skin Absorption - drug effects Skin Aging - drug effects Solid lipid nanoparticles Surface modification Surface Properties Vitamin A - administration & dosage Vitamin A - analogs & derivatives Vitamin A - chemistry Vitamin A - pharmacokinetics
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