Endothelial dysfunction associated with mild cognitive impairment in elderly population
Background and aims According to the original Petersen criteria, we investigated the association between endothelial dysfunction and mild cognitive impairment (MCI) by flow-mediated dilation (FMD). We aimed to verify if endothelial dysfunction occurs in MCI and whether vascular factors are implicate...
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| Veröffentlicht in: | Aging clinical and experimental research 2013-06, Vol.25 (3), p.247-255 |
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| creator | Vendemiale, Gianluigi Romano, Antonino D. Dagostino, Mariangela de Matthaeis, Angela Serviddio, Gaetano |
| description | Background and aims
According to the original Petersen criteria, we investigated the association between endothelial dysfunction and mild cognitive impairment (MCI) by flow-mediated dilation (FMD). We aimed to verify if endothelial dysfunction occurs in MCI and whether vascular factors are implicated in the MCI pathogenesis.
Methods
This is a cross-sectional study performed on 34 subjects with clinical diagnosis of MCI and 37 controls, older than 60 years. Patients were enrolled from a geriatric outpatient clinic. All the recognized cardiovascular risk factors and an objective state of cognitive impairment were used as exclusion criteria. Cognitive function was evaluated using a scientific-validated neuropsychological battery, whereas MCI was recognized according to the Petersen criteria. Endothelial function was evaluated according to FMD from the brachial artery. The association between FMD and MCI was evaluated both by using a multivariate analysis and a correlation test. Finally, using the ANOVA analysis of variance, we tested the differences in flow-mediated dilation among MCI subgroups.
Results
Brachial FMD was significantly associated with MCI (
p
|
| doi_str_mv | 10.1007/s40520-013-0043-8 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1371268066</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2348930766</sourcerecordid><originalsourceid>FETCH-LOGICAL-c372t-779721cdfd84b2d67b6b7150859bab8f423ee1647efb48bcf196b5d1a9fe5c7a3</originalsourceid><addsrcrecordid>eNp1kEtrFTEYhoNY7PUHuCkBN27G5jIzySxLOWqh4KbFZcjlmzYlk4zJTMv59-Z4ahXBVW7P-37hQeg9JZ8oIeKitKRjpCGUN4S0vJFv0BEV9UZyOrz9a3-Ijkt5rAyth3fokHFRo7I9Qt830aXlAYLXAbttGddoF58i1qUk6_UCDj_75QFPPjhs0330i38C7KdZ-zxBXLCPGIKDHLZ4TvMa9C5_ig5GHQqcvawn6O7z5vbqa3Pz7cv11eVNY7lgSyPEIBi1bnSyNcz1wvRG0I7IbjDayLFlHID2rYDRtNLYkQ696RzVwwidFZqfoI_73jmnHyuURU2-WAhBR0hrUZQLynpJ-r6iH_5BH9OaY_2dYryVAyfiF0X3lM2plAyjmrOfdN4qStTOutpbV9W62llXsmbOX5pXM4F7TfzWXAG2B0p9iveQ_4z-f-tPXNqN8A</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2348930766</pqid></control><display><type>article</type><title>Endothelial dysfunction associated with mild cognitive impairment in elderly population</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Vendemiale, Gianluigi ; Romano, Antonino D. ; Dagostino, Mariangela ; de Matthaeis, Angela ; Serviddio, Gaetano</creator><creatorcontrib>Vendemiale, Gianluigi ; Romano, Antonino D. ; Dagostino, Mariangela ; de Matthaeis, Angela ; Serviddio, Gaetano</creatorcontrib><description>Background and aims
According to the original Petersen criteria, we investigated the association between endothelial dysfunction and mild cognitive impairment (MCI) by flow-mediated dilation (FMD). We aimed to verify if endothelial dysfunction occurs in MCI and whether vascular factors are implicated in the MCI pathogenesis.
Methods
This is a cross-sectional study performed on 34 subjects with clinical diagnosis of MCI and 37 controls, older than 60 years. Patients were enrolled from a geriatric outpatient clinic. All the recognized cardiovascular risk factors and an objective state of cognitive impairment were used as exclusion criteria. Cognitive function was evaluated using a scientific-validated neuropsychological battery, whereas MCI was recognized according to the Petersen criteria. Endothelial function was evaluated according to FMD from the brachial artery. The association between FMD and MCI was evaluated both by using a multivariate analysis and a correlation test. Finally, using the ANOVA analysis of variance, we tested the differences in flow-mediated dilation among MCI subgroups.
Results
Brachial FMD was significantly associated with MCI (
p
< 0.01). The multivariate analysis showed that age, years of education and MMSE independently predicted the FMD variation (
r
2
= 0.73;
p
< 0.0001). In addition, MCI patients with prevalent amnestic multiple domain impairment showed the worst brachial FMD.
Conclusions
This finding suggests that vascular dysfunction may play a role in the pathogenesis of cognitive impairment and underlines the lack of therapeutic strategies targeted to such dysfunctions.</description><identifier>ISSN: 1720-8319</identifier><identifier>ISSN: 1594-0667</identifier><identifier>EISSN: 1720-8319</identifier><identifier>DOI: 10.1007/s40520-013-0043-8</identifier><identifier>PMID: 23740584</identifier><language>eng</language><publisher>Cham: Springer International Publishing AG</publisher><subject>Aged ; Aging - physiology ; Brachial Artery - diagnostic imaging ; Brachial Artery - physiopathology ; Case-Control Studies ; Cognition Disorders - epidemiology ; Cognition Disorders - etiology ; Cognition Disorders - physiopathology ; Cognitive ability ; Cross-Sectional Studies ; Endothelium, Vascular - diagnostic imaging ; Endothelium, Vascular - physiopathology ; Female ; Geriatrics/Gerontology ; Humans ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Multivariate Analysis ; Neuropsychological Tests ; Original Article ; Oxidative stress ; Pathogenesis ; Prevalence ; Ultrasonography ; Variance analysis</subject><ispartof>Aging clinical and experimental research, 2013-06, Vol.25 (3), p.247-255</ispartof><rights>Springer International Publishing Switzerland 2013</rights><rights>Aging Clinical and Experimental Research is a copyright of Springer, (2013). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-779721cdfd84b2d67b6b7150859bab8f423ee1647efb48bcf196b5d1a9fe5c7a3</citedby><cites>FETCH-LOGICAL-c372t-779721cdfd84b2d67b6b7150859bab8f423ee1647efb48bcf196b5d1a9fe5c7a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s40520-013-0043-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s40520-013-0043-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23740584$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vendemiale, Gianluigi</creatorcontrib><creatorcontrib>Romano, Antonino D.</creatorcontrib><creatorcontrib>Dagostino, Mariangela</creatorcontrib><creatorcontrib>de Matthaeis, Angela</creatorcontrib><creatorcontrib>Serviddio, Gaetano</creatorcontrib><title>Endothelial dysfunction associated with mild cognitive impairment in elderly population</title><title>Aging clinical and experimental research</title><addtitle>Aging Clin Exp Res</addtitle><addtitle>Aging Clin Exp Res</addtitle><description>Background and aims
According to the original Petersen criteria, we investigated the association between endothelial dysfunction and mild cognitive impairment (MCI) by flow-mediated dilation (FMD). We aimed to verify if endothelial dysfunction occurs in MCI and whether vascular factors are implicated in the MCI pathogenesis.
Methods
This is a cross-sectional study performed on 34 subjects with clinical diagnosis of MCI and 37 controls, older than 60 years. Patients were enrolled from a geriatric outpatient clinic. All the recognized cardiovascular risk factors and an objective state of cognitive impairment were used as exclusion criteria. Cognitive function was evaluated using a scientific-validated neuropsychological battery, whereas MCI was recognized according to the Petersen criteria. Endothelial function was evaluated according to FMD from the brachial artery. The association between FMD and MCI was evaluated both by using a multivariate analysis and a correlation test. Finally, using the ANOVA analysis of variance, we tested the differences in flow-mediated dilation among MCI subgroups.
Results
Brachial FMD was significantly associated with MCI (
p
< 0.01). The multivariate analysis showed that age, years of education and MMSE independently predicted the FMD variation (
r
2
= 0.73;
p
< 0.0001). In addition, MCI patients with prevalent amnestic multiple domain impairment showed the worst brachial FMD.
Conclusions
This finding suggests that vascular dysfunction may play a role in the pathogenesis of cognitive impairment and underlines the lack of therapeutic strategies targeted to such dysfunctions.</description><subject>Aged</subject><subject>Aging - physiology</subject><subject>Brachial Artery - diagnostic imaging</subject><subject>Brachial Artery - physiopathology</subject><subject>Case-Control Studies</subject><subject>Cognition Disorders - epidemiology</subject><subject>Cognition Disorders - etiology</subject><subject>Cognition Disorders - physiopathology</subject><subject>Cognitive ability</subject><subject>Cross-Sectional Studies</subject><subject>Endothelium, Vascular - diagnostic imaging</subject><subject>Endothelium, Vascular - physiopathology</subject><subject>Female</subject><subject>Geriatrics/Gerontology</subject><subject>Humans</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Neuropsychological Tests</subject><subject>Original Article</subject><subject>Oxidative stress</subject><subject>Pathogenesis</subject><subject>Prevalence</subject><subject>Ultrasonography</subject><subject>Variance analysis</subject><issn>1720-8319</issn><issn>1594-0667</issn><issn>1720-8319</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kEtrFTEYhoNY7PUHuCkBN27G5jIzySxLOWqh4KbFZcjlmzYlk4zJTMv59-Z4ahXBVW7P-37hQeg9JZ8oIeKitKRjpCGUN4S0vJFv0BEV9UZyOrz9a3-Ijkt5rAyth3fokHFRo7I9Qt830aXlAYLXAbttGddoF58i1qUk6_UCDj_75QFPPjhs0330i38C7KdZ-zxBXLCPGIKDHLZ4TvMa9C5_ig5GHQqcvawn6O7z5vbqa3Pz7cv11eVNY7lgSyPEIBi1bnSyNcz1wvRG0I7IbjDayLFlHID2rYDRtNLYkQ696RzVwwidFZqfoI_73jmnHyuURU2-WAhBR0hrUZQLynpJ-r6iH_5BH9OaY_2dYryVAyfiF0X3lM2plAyjmrOfdN4qStTOutpbV9W62llXsmbOX5pXM4F7TfzWXAG2B0p9iveQ_4z-f-tPXNqN8A</recordid><startdate>20130601</startdate><enddate>20130601</enddate><creator>Vendemiale, Gianluigi</creator><creator>Romano, Antonino D.</creator><creator>Dagostino, Mariangela</creator><creator>de Matthaeis, Angela</creator><creator>Serviddio, Gaetano</creator><general>Springer International Publishing AG</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20130601</creationdate><title>Endothelial dysfunction associated with mild cognitive impairment in elderly population</title><author>Vendemiale, Gianluigi ; Romano, Antonino D. ; Dagostino, Mariangela ; de Matthaeis, Angela ; Serviddio, Gaetano</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-779721cdfd84b2d67b6b7150859bab8f423ee1647efb48bcf196b5d1a9fe5c7a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Aged</topic><topic>Aging - physiology</topic><topic>Brachial Artery - diagnostic imaging</topic><topic>Brachial Artery - physiopathology</topic><topic>Case-Control Studies</topic><topic>Cognition Disorders - epidemiology</topic><topic>Cognition Disorders - etiology</topic><topic>Cognition Disorders - physiopathology</topic><topic>Cognitive ability</topic><topic>Cross-Sectional Studies</topic><topic>Endothelium, Vascular - diagnostic imaging</topic><topic>Endothelium, Vascular - physiopathology</topic><topic>Female</topic><topic>Geriatrics/Gerontology</topic><topic>Humans</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Neuropsychological Tests</topic><topic>Original Article</topic><topic>Oxidative stress</topic><topic>Pathogenesis</topic><topic>Prevalence</topic><topic>Ultrasonography</topic><topic>Variance analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vendemiale, Gianluigi</creatorcontrib><creatorcontrib>Romano, Antonino D.</creatorcontrib><creatorcontrib>Dagostino, Mariangela</creatorcontrib><creatorcontrib>de Matthaeis, Angela</creatorcontrib><creatorcontrib>Serviddio, Gaetano</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Aging clinical and experimental research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vendemiale, Gianluigi</au><au>Romano, Antonino D.</au><au>Dagostino, Mariangela</au><au>de Matthaeis, Angela</au><au>Serviddio, Gaetano</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Endothelial dysfunction associated with mild cognitive impairment in elderly population</atitle><jtitle>Aging clinical and experimental research</jtitle><stitle>Aging Clin Exp Res</stitle><addtitle>Aging Clin Exp Res</addtitle><date>2013-06-01</date><risdate>2013</risdate><volume>25</volume><issue>3</issue><spage>247</spage><epage>255</epage><pages>247-255</pages><issn>1720-8319</issn><issn>1594-0667</issn><eissn>1720-8319</eissn><abstract>Background and aims
According to the original Petersen criteria, we investigated the association between endothelial dysfunction and mild cognitive impairment (MCI) by flow-mediated dilation (FMD). We aimed to verify if endothelial dysfunction occurs in MCI and whether vascular factors are implicated in the MCI pathogenesis.
Methods
This is a cross-sectional study performed on 34 subjects with clinical diagnosis of MCI and 37 controls, older than 60 years. Patients were enrolled from a geriatric outpatient clinic. All the recognized cardiovascular risk factors and an objective state of cognitive impairment were used as exclusion criteria. Cognitive function was evaluated using a scientific-validated neuropsychological battery, whereas MCI was recognized according to the Petersen criteria. Endothelial function was evaluated according to FMD from the brachial artery. The association between FMD and MCI was evaluated both by using a multivariate analysis and a correlation test. Finally, using the ANOVA analysis of variance, we tested the differences in flow-mediated dilation among MCI subgroups.
Results
Brachial FMD was significantly associated with MCI (
p
< 0.01). The multivariate analysis showed that age, years of education and MMSE independently predicted the FMD variation (
r
2
= 0.73;
p
< 0.0001). In addition, MCI patients with prevalent amnestic multiple domain impairment showed the worst brachial FMD.
Conclusions
This finding suggests that vascular dysfunction may play a role in the pathogenesis of cognitive impairment and underlines the lack of therapeutic strategies targeted to such dysfunctions.</abstract><cop>Cham</cop><pub>Springer International Publishing AG</pub><pmid>23740584</pmid><doi>10.1007/s40520-013-0043-8</doi><tpages>9</tpages></addata></record> |
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| ispartof | Aging clinical and experimental research, 2013-06, Vol.25 (3), p.247-255 |
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| subjects | Aged Aging - physiology Brachial Artery - diagnostic imaging Brachial Artery - physiopathology Case-Control Studies Cognition Disorders - epidemiology Cognition Disorders - etiology Cognition Disorders - physiopathology Cognitive ability Cross-Sectional Studies Endothelium, Vascular - diagnostic imaging Endothelium, Vascular - physiopathology Female Geriatrics/Gerontology Humans Male Medicine Medicine & Public Health Middle Aged Multivariate Analysis Neuropsychological Tests Original Article Oxidative stress Pathogenesis Prevalence Ultrasonography Variance analysis |
| title | Endothelial dysfunction associated with mild cognitive impairment in elderly population |
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