JNK regulates compliance-induced adherens junctions formation in epithelial cells and tissues

We demonstrate that c-Jun N-terminal kinase (JNK) responds to substrate stiffness and regulates adherens junction (AJ) formation in epithelial cells in 2D cultures and in 3D tissues in vitro and in vivo. Rigid substrates led to JNK activation and AJ disassembly, whereas soft matrices suppressed JNK...

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Veröffentlicht in:	Journal of cell science 2013-06, Vol.126 (Pt 12), p.2718-2729
Hauptverfasser:	You, Hui, Padmashali, Roshan M, Ranganathan, Aishwarya, Lei, Pedro, Girnius, Nomeda, Davis, Roger J, Andreadis, Stelios T
Format:	Artikel
Sprache:	eng
Schlagworte:	Adherens Junctions - metabolism Animals Cells, Cultured Epidermis - cytology Epidermis - metabolism Epithelial Cells - cytology Epithelial Cells - metabolism Humans JNK Mitogen-Activated Protein Kinases - metabolism Keratinocytes - cytology Keratinocytes - metabolism MAP Kinase Kinase 7 - metabolism Mice Mitogen-Activated Protein Kinase 8 - metabolism Mitogen-Activated Protein Kinase 9 - metabolism Phosphorylation
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