The role of transforming growth factor-beta in Marfan syndrome

The starting point, in Marfan syndrome (MFS) appears to be the mutation of fibrillin-1 gene whose deconstructed protein product cannot bind transforming growth factor beta (TGF-b), leading to an increased TGF-b tissue level. The aim of this review is to review the already known features of the cellu...

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Veröffentlicht in:	Cardiology journal 2013, Vol.20 (3), p.227-234
Hauptverfasser:	Benke, Kálmán, Ágg, Bence, Szilveszter, Bálint, Tarr, Ferenc, Nagy, Zsolt B, Pólos, Miklós, Daróczi, László, Merkely, Béla, Szabolcs, Zoltán
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aortic Aneurysm - etiology Aortic Aneurysm - metabolism Aortic Aneurysm - prevention & control Aortic aneurysms Growth factors Humans Marfan syndrome Marfan Syndrome - complications Marfan Syndrome - drug therapy Marfan Syndrome - metabolism Prognosis Signal transduction Signal Transduction - drug effects Transforming Growth Factor beta - metabolism
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