IL‐12‐mediated STAT4 signaling and TCR signal strength cooperate in the induction of CD40L in human and mouse CD8+ T cells

CD40L is one of the key molecules bridging the activation of specific T cells and the maturation of professional and nonprofessional antigen‐presenting cells including B cells. CD4+ T cells have been regarded as the major T‐cell subset that expresses CD40L upon cognate activation; however, we demons...

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Veröffentlicht in:	European journal of immunology 2013-06, Vol.43 (6), p.1511-1517
Hauptverfasser:	Stark, Regina, Hartung, Anett, Zehn, Dietmar, Frentsch, Marco, Thiel, Andreas
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigen-Presenting Cells - immunology CD40 Ligand - genetics CD40 Ligand - immunology CD40 Ligand - metabolism CD40L CD8+ T cells CD8-Positive T-Lymphocytes - immunology Cell Communication Cells, Cultured Costimulatory molecules Humans Immunology Interleukin-12 - immunology Lymphocyte Activation Lymphocytes Mice Mice, Inbred C57BL Mice, Transgenic Receptor Cross-Talk Receptors, Antigen, T-Cell - genetics Receptors, Antigen, T-Cell - immunology Receptors, Antigen, T-Cell - metabolism Signal Transduction STAT4 signaling STAT4 Transcription Factor - immunology STAT4 Transcription Factor - metabolism T cell receptors T-Lymphocytes, Helper-Inducer - immunology TCR Up-Regulation
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