Efficacy and safety of the treatment: combination of benazepril/ lercanidipine vs. benazepril alone in patients with mild-to-moderate hypertension

Background Combination therapy is an effective method to reduce the blood pressure (BP) for patients with hypertension.This study was performed to evaluate the efficacy and safety of benazepril/lercanidipine compared with benazepril alone in patients with mild-to-moderate hypertension.Methods One hu...

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Veröffentlicht in:Chinese medical journal 2013-06, Vol.126 (12), p.2286-2290
Hauptverfasser: Chen, Ting, Chen, Guang-Hui, Yang, Ting-Shu, Zhong, Zhen-Yu, An, Wei-Shuai, Zhang, Xiao-Xia, Li, Jia-Dan
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container_end_page 2290
container_issue 12
container_start_page 2286
container_title Chinese medical journal
container_volume 126
creator Chen, Ting
Chen, Guang-Hui
Yang, Ting-Shu
Zhong, Zhen-Yu
An, Wei-Shuai
Zhang, Xiao-Xia
Li, Jia-Dan
description Background Combination therapy is an effective method to reduce the blood pressure (BP) for patients with hypertension.This study was performed to evaluate the efficacy and safety of benazepril/lercanidipine compared with benazepril alone in patients with mild-to-moderate hypertension.Methods One hundred and eighty-one patients with mild-to-moderate primary hypertension were assigned in this randomized,single-blind,parallel-group study and were randomly divided into group A (benazepril 10 mg/lercanidipine 10 mg) and group B (benazepril 10 mg) for 8 weeks.At 4 weeks,the dosage of Benazepril was titrated up to 20 mg if the diastolic blood pressure (DBP) remained ≥90 mmHg.BP control and side effects were evaluated at the end of 1,4 and 8 weeks.Results The baseline characteristics of the two groups were similar.The BP in both groups decreased from the baseline (P 〈0.05).At the end of 4 and 8 weeks,Benazepril/Lercanidipine produced greater BP reduction than Benazepril alone (P 〈0.05).The comparison of the rate of BP control for the benazepril/lercanidipine and benazepril groups at the end of 1,4,and 8 weeks were 41.2% vs.37.6% (P 〉0.05),67.1% vs.44.7% (P 〈0.05),and 71.8% vs.45.9% (P 〈0.05).There was no significant difference of side effects between the two groups.Conclusion The benazepril/lercanidipine combination is more effective in reducing BP than benazepril alone,while it does not increase the incidence of side effects.
doi_str_mv 10.3760/cma.j.issn.0366-6999.20122794
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Chen, Guang-Hui ; Yang, Ting-Shu ; Zhong, Zhen-Yu ; An, Wei-Shuai ; Zhang, Xiao-Xia ; Li, Jia-Dan</creator><creatorcontrib>Chen, Ting ; Chen, Guang-Hui ; Yang, Ting-Shu ; Zhong, Zhen-Yu ; An, Wei-Shuai ; Zhang, Xiao-Xia ; Li, Jia-Dan</creatorcontrib><description>Background Combination therapy is an effective method to reduce the blood pressure (BP) for patients with hypertension.This study was performed to evaluate the efficacy and safety of benazepril/lercanidipine compared with benazepril alone in patients with mild-to-moderate hypertension.Methods One hundred and eighty-one patients with mild-to-moderate primary hypertension were assigned in this randomized,single-blind,parallel-group study and were randomly divided into group A (benazepril 10 mg/lercanidipine 10 mg) and group B (benazepril 10 mg) for 8 weeks.At 4 weeks,the dosage of Benazepril was titrated up to 20 mg if the diastolic blood pressure (DBP) remained ≥90 mmHg.BP control and side effects were evaluated at the end of 1,4 and 8 weeks.Results The baseline characteristics of the two groups were similar.The BP in both groups decreased from the baseline (P 〈0.05).At the end of 4 and 8 weeks,Benazepril/Lercanidipine produced greater BP reduction than Benazepril alone (P 〈0.05).The comparison of the rate of BP control for the benazepril/lercanidipine and benazepril groups at the end of 1,4,and 8 weeks were 41.2% vs.37.6% (P 〉0.05),67.1% vs.44.7% (P 〈0.05),and 71.8% vs.45.9% (P 〈0.05).There was no significant difference of side effects between the two groups.Conclusion The benazepril/lercanidipine combination is more effective in reducing BP than benazepril alone,while it does not increase the incidence of side effects.</description><identifier>ISSN: 0366-6999</identifier><identifier>EISSN: 2542-5641</identifier><identifier>DOI: 10.3760/cma.j.issn.0366-6999.20122794</identifier><identifier>PMID: 23786940</identifier><language>eng</language><publisher>China</publisher><subject>Aged ; Angiotensin-Converting Enzyme Inhibitors - therapeutic use ; Benzazepines - administration &amp; dosage ; Benzazepines - adverse effects ; Benzazepines - therapeutic use ; Blood Pressure - drug effects ; Calcium Channel Blockers - administration &amp; dosage ; DBP ; Dihydropyridines - administration &amp; dosage ; Dihydropyridines - adverse effects ; Drug Therapy, Combination ; Female ; Humans ; Hypertension - drug therapy ; Male ; Middle Aged ; Single-Blind Method ; 副作用 ; 地平 ; 安全性 ; 毫米汞柱 ; 疗效 ; 结合治疗 ; 高血压患者</subject><ispartof>Chinese medical journal, 2013-06, Vol.126 (12), p.2286-2290</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c346t-d0f397bcb31c866cb349f287d1e0e7dd1b657060fc62ea7d9f9644f22251d6c13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/85656X/85656X.jpg</thumbnail><link.rule.ids>315,781,785,865,27929,27930</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23786940$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Ting</creatorcontrib><creatorcontrib>Chen, Guang-Hui</creatorcontrib><creatorcontrib>Yang, Ting-Shu</creatorcontrib><creatorcontrib>Zhong, Zhen-Yu</creatorcontrib><creatorcontrib>An, Wei-Shuai</creatorcontrib><creatorcontrib>Zhang, Xiao-Xia</creatorcontrib><creatorcontrib>Li, Jia-Dan</creatorcontrib><title>Efficacy and safety of the treatment: combination of benazepril/ lercanidipine vs. benazepril alone in patients with mild-to-moderate hypertension</title><title>Chinese medical journal</title><addtitle>Chinese Medical Journal</addtitle><description>Background Combination therapy is an effective method to reduce the blood pressure (BP) for patients with hypertension.This study was performed to evaluate the efficacy and safety of benazepril/lercanidipine compared with benazepril alone in patients with mild-to-moderate hypertension.Methods One hundred and eighty-one patients with mild-to-moderate primary hypertension were assigned in this randomized,single-blind,parallel-group study and were randomly divided into group A (benazepril 10 mg/lercanidipine 10 mg) and group B (benazepril 10 mg) for 8 weeks.At 4 weeks,the dosage of Benazepril was titrated up to 20 mg if the diastolic blood pressure (DBP) remained ≥90 mmHg.BP control and side effects were evaluated at the end of 1,4 and 8 weeks.Results The baseline characteristics of the two groups were similar.The BP in both groups decreased from the baseline (P 〈0.05).At the end of 4 and 8 weeks,Benazepril/Lercanidipine produced greater BP reduction than Benazepril alone (P 〈0.05).The comparison of the rate of BP control for the benazepril/lercanidipine and benazepril groups at the end of 1,4,and 8 weeks were 41.2% vs.37.6% (P 〉0.05),67.1% vs.44.7% (P 〈0.05),and 71.8% vs.45.9% (P 〈0.05).There was no significant difference of side effects between the two groups.Conclusion The benazepril/lercanidipine combination is more effective in reducing BP than benazepril alone,while it does not increase the incidence of side effects.</description><subject>Aged</subject><subject>Angiotensin-Converting Enzyme Inhibitors - therapeutic use</subject><subject>Benzazepines - administration &amp; dosage</subject><subject>Benzazepines - adverse effects</subject><subject>Benzazepines - therapeutic use</subject><subject>Blood Pressure - drug effects</subject><subject>Calcium Channel Blockers - administration &amp; dosage</subject><subject>DBP</subject><subject>Dihydropyridines - administration &amp; dosage</subject><subject>Dihydropyridines - adverse effects</subject><subject>Drug Therapy, Combination</subject><subject>Female</subject><subject>Humans</subject><subject>Hypertension - drug therapy</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Single-Blind Method</subject><subject>副作用</subject><subject>地平</subject><subject>安全性</subject><subject>毫米汞柱</subject><subject>疗效</subject><subject>结合治疗</subject><subject>高血压患者</subject><issn>0366-6999</issn><issn>2542-5641</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkU1qHDEQhUWIiSdOrhCURcCbbuuv1dOLLIJxfsCQjbMWaqnk0dAttVuamPE5vPJZcqdcIWo8HrIqqPpePaoeQp8oqXkryYUZdb2tfUqhJlzKSnZdVzNCGWs78QqtWCNY1UhBX6PVEThFb1PaEsKappVv0Cnj7Vp2gqzQ45Vz3mizxzpYnLSDvMfR4bwBnGfQeYSQ__55wiaOvQ86-xiWeQ9BP8A0--ECDzAbHbz1kw-Af6f6vynWQyxNH_BUtGVXwvc-b_DoB1vlWI3Rwqwz4M1-gjlDSMXgHTpxekjw_lDP0K-vVzeX36vrn99-XH65rgwXMleWON61vek5NWspSxWdY-vWUiDQWkt72bREEmckA93aznVSCMcYa6iVhvIzdP68d5rj3Q5SVqNPBoZBB4i7pCgvcr6mfEE_P6NmjinN4FS5btTzXlGilmBUCUZt1RKMWv6ulr-rl2CK_sPBatePYI_qlyQK8PFgsInh9s6H2yMjpJDlEsr_ATRQnQ0</recordid><startdate>20130620</startdate><enddate>20130620</enddate><creator>Chen, Ting</creator><creator>Chen, Guang-Hui</creator><creator>Yang, Ting-Shu</creator><creator>Zhong, Zhen-Yu</creator><creator>An, Wei-Shuai</creator><creator>Zhang, Xiao-Xia</creator><creator>Li, Jia-Dan</creator><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20130620</creationdate><title>Efficacy and safety of the treatment: combination of benazepril/ lercanidipine vs. benazepril alone in patients with mild-to-moderate hypertension</title><author>Chen, Ting ; Chen, Guang-Hui ; Yang, Ting-Shu ; Zhong, Zhen-Yu ; An, Wei-Shuai ; Zhang, Xiao-Xia ; Li, Jia-Dan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c346t-d0f397bcb31c866cb349f287d1e0e7dd1b657060fc62ea7d9f9644f22251d6c13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Aged</topic><topic>Angiotensin-Converting Enzyme Inhibitors - therapeutic use</topic><topic>Benzazepines - administration &amp; dosage</topic><topic>Benzazepines - adverse effects</topic><topic>Benzazepines - therapeutic use</topic><topic>Blood Pressure - drug effects</topic><topic>Calcium Channel Blockers - administration &amp; dosage</topic><topic>DBP</topic><topic>Dihydropyridines - administration &amp; dosage</topic><topic>Dihydropyridines - adverse effects</topic><topic>Drug Therapy, Combination</topic><topic>Female</topic><topic>Humans</topic><topic>Hypertension - drug therapy</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Single-Blind Method</topic><topic>副作用</topic><topic>地平</topic><topic>安全性</topic><topic>毫米汞柱</topic><topic>疗效</topic><topic>结合治疗</topic><topic>高血压患者</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Ting</creatorcontrib><creatorcontrib>Chen, Guang-Hui</creatorcontrib><creatorcontrib>Yang, Ting-Shu</creatorcontrib><creatorcontrib>Zhong, Zhen-Yu</creatorcontrib><creatorcontrib>An, Wei-Shuai</creatorcontrib><creatorcontrib>Zhang, Xiao-Xia</creatorcontrib><creatorcontrib>Li, Jia-Dan</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库-医药卫生</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Chinese medical journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Ting</au><au>Chen, Guang-Hui</au><au>Yang, Ting-Shu</au><au>Zhong, Zhen-Yu</au><au>An, Wei-Shuai</au><au>Zhang, Xiao-Xia</au><au>Li, Jia-Dan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Efficacy and safety of the treatment: combination of benazepril/ lercanidipine vs. benazepril alone in patients with mild-to-moderate hypertension</atitle><jtitle>Chinese medical journal</jtitle><addtitle>Chinese Medical Journal</addtitle><date>2013-06-20</date><risdate>2013</risdate><volume>126</volume><issue>12</issue><spage>2286</spage><epage>2290</epage><pages>2286-2290</pages><issn>0366-6999</issn><eissn>2542-5641</eissn><abstract>Background Combination therapy is an effective method to reduce the blood pressure (BP) for patients with hypertension.This study was performed to evaluate the efficacy and safety of benazepril/lercanidipine compared with benazepril alone in patients with mild-to-moderate hypertension.Methods One hundred and eighty-one patients with mild-to-moderate primary hypertension were assigned in this randomized,single-blind,parallel-group study and were randomly divided into group A (benazepril 10 mg/lercanidipine 10 mg) and group B (benazepril 10 mg) for 8 weeks.At 4 weeks,the dosage of Benazepril was titrated up to 20 mg if the diastolic blood pressure (DBP) remained ≥90 mmHg.BP control and side effects were evaluated at the end of 1,4 and 8 weeks.Results The baseline characteristics of the two groups were similar.The BP in both groups decreased from the baseline (P 〈0.05).At the end of 4 and 8 weeks,Benazepril/Lercanidipine produced greater BP reduction than Benazepril alone (P 〈0.05).The comparison of the rate of BP control for the benazepril/lercanidipine and benazepril groups at the end of 1,4,and 8 weeks were 41.2% vs.37.6% (P 〉0.05),67.1% vs.44.7% (P 〈0.05),and 71.8% vs.45.9% (P 〈0.05).There was no significant difference of side effects between the two groups.Conclusion The benazepril/lercanidipine combination is more effective in reducing BP than benazepril alone,while it does not increase the incidence of side effects.</abstract><cop>China</cop><pmid>23786940</pmid><doi>10.3760/cma.j.issn.0366-6999.20122794</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record>
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subjects Aged
Angiotensin-Converting Enzyme Inhibitors - therapeutic use
Benzazepines - administration & dosage
Benzazepines - adverse effects
Benzazepines - therapeutic use
Blood Pressure - drug effects
Calcium Channel Blockers - administration & dosage
DBP
Dihydropyridines - administration & dosage
Dihydropyridines - adverse effects
Drug Therapy, Combination
Female
Humans
Hypertension - drug therapy
Male
Middle Aged
Single-Blind Method
副作用
地平
安全性
毫米汞柱
疗效
结合治疗
高血压患者
title Efficacy and safety of the treatment: combination of benazepril/ lercanidipine vs. benazepril alone in patients with mild-to-moderate hypertension
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