The correlation between expression of synuclein-gamma, glucose transporter-1, and survival outcomes in endometrioid endometrial carcinoma
To evaluate the correlation between immunohistochemical expression of synuclein-gamma, glucose transporter-1, and survival outcomes in endometrioid endometrial carcinoma. A tissue microarray was constructed using formalinfixed, paraffin-embedded tissue that included 23 early and 18 advanced cases. T...
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| Veröffentlicht in: | European journal of gynaecological oncology 2013, Vol.34 (2), p.128-131 |
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| container_title | European journal of gynaecological oncology |
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| creator | Hong, D G Park, N Y Chong, G O Cho, Y L Park, I S Jeong, M J Park, J Y Lee, Y S |
| description | To evaluate the correlation between immunohistochemical expression of synuclein-gamma, glucose transporter-1, and survival outcomes in endometrioid endometrial carcinoma.
A tissue microarray was constructed using formalinfixed, paraffin-embedded tissue that included 23 early and 18 advanced cases. The intensity and area of the immunohistochemical reactions were evaluated using the semi-quantitative scoring system.
Synuclein-y expression was higher in the advanced stage, although it was not statistically significant (p = 0.51). Glucose transporter-1 was overexpressed in the advanced stage (p = 0.01). Synuclein-gamma (score = 0 vs > 0) and glucose transporter-1 (score < or = 7 vs > 7) did not show any differences in overall survival (p = 0.54, p = 0.48) and disease-free survival (p = 0.61, p = 0.14).
In this study the expression of synuclein-y and glucose transporter-1 were not considered to be a prognostic factor and were not related with survival outcomes in endometrioid endometrial carcinoma. |
| format | Article |
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A tissue microarray was constructed using formalinfixed, paraffin-embedded tissue that included 23 early and 18 advanced cases. The intensity and area of the immunohistochemical reactions were evaluated using the semi-quantitative scoring system.
Synuclein-y expression was higher in the advanced stage, although it was not statistically significant (p = 0.51). Glucose transporter-1 was overexpressed in the advanced stage (p = 0.01). Synuclein-gamma (score = 0 vs > 0) and glucose transporter-1 (score < or = 7 vs > 7) did not show any differences in overall survival (p = 0.54, p = 0.48) and disease-free survival (p = 0.61, p = 0.14).
In this study the expression of synuclein-y and glucose transporter-1 were not considered to be a prognostic factor and were not related with survival outcomes in endometrioid endometrial carcinoma.</description><identifier>ISSN: 0392-2936</identifier><identifier>PMID: 23781582</identifier><language>eng</language><publisher>Italy</publisher><subject>Adult ; Aged ; Carcinoma, Endometrioid - chemistry ; Carcinoma, Endometrioid - mortality ; Carcinoma, Endometrioid - pathology ; Endometrial Neoplasms - chemistry ; Endometrial Neoplasms - mortality ; Endometrial Neoplasms - pathology ; Female ; gamma-Synuclein - analysis ; Glucose Transporter Type 1 - analysis ; Humans ; Immunohistochemistry ; Middle Aged ; Neoplasm Proteins - analysis ; Neoplasm Staging ; Tissue Array Analysis</subject><ispartof>European journal of gynaecological oncology, 2013, Vol.34 (2), p.128-131</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4010</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23781582$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hong, D G</creatorcontrib><creatorcontrib>Park, N Y</creatorcontrib><creatorcontrib>Chong, G O</creatorcontrib><creatorcontrib>Cho, Y L</creatorcontrib><creatorcontrib>Park, I S</creatorcontrib><creatorcontrib>Jeong, M J</creatorcontrib><creatorcontrib>Park, J Y</creatorcontrib><creatorcontrib>Lee, Y S</creatorcontrib><title>The correlation between expression of synuclein-gamma, glucose transporter-1, and survival outcomes in endometrioid endometrial carcinoma</title><title>European journal of gynaecological oncology</title><addtitle>Eur J Gynaecol Oncol</addtitle><description>To evaluate the correlation between immunohistochemical expression of synuclein-gamma, glucose transporter-1, and survival outcomes in endometrioid endometrial carcinoma.
A tissue microarray was constructed using formalinfixed, paraffin-embedded tissue that included 23 early and 18 advanced cases. The intensity and area of the immunohistochemical reactions were evaluated using the semi-quantitative scoring system.
Synuclein-y expression was higher in the advanced stage, although it was not statistically significant (p = 0.51). Glucose transporter-1 was overexpressed in the advanced stage (p = 0.01). Synuclein-gamma (score = 0 vs > 0) and glucose transporter-1 (score < or = 7 vs > 7) did not show any differences in overall survival (p = 0.54, p = 0.48) and disease-free survival (p = 0.61, p = 0.14).
In this study the expression of synuclein-y and glucose transporter-1 were not considered to be a prognostic factor and were not related with survival outcomes in endometrioid endometrial carcinoma.</description><subject>Adult</subject><subject>Aged</subject><subject>Carcinoma, Endometrioid - chemistry</subject><subject>Carcinoma, Endometrioid - mortality</subject><subject>Carcinoma, Endometrioid - pathology</subject><subject>Endometrial Neoplasms - chemistry</subject><subject>Endometrial Neoplasms - mortality</subject><subject>Endometrial Neoplasms - pathology</subject><subject>Female</subject><subject>gamma-Synuclein - analysis</subject><subject>Glucose Transporter Type 1 - analysis</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Middle Aged</subject><subject>Neoplasm Proteins - analysis</subject><subject>Neoplasm Staging</subject><subject>Tissue Array Analysis</subject><issn>0392-2936</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkLtOwzAYhT2AaCm8AvLI0Ei2E8fpiCoulSqxlDn64_wpRo4dbKfQR-CtCaKI6Vz06QznjMxZvhKZWOXljFzG-MZYUahSXJCZyFXFZSXm5Gv3ilT7ENBCMt7RBtMHoqP4OQSM8afyHY1HN2qLxmV76HtY0r0dtY9IUwAXBx8ShowvKbiWxjEczAEs9WPSvsdIzTTn2smmYLxp_8MEaQjaON_DFTnvwEa8PumCvDzc79ZP2fb5cbO-22aD4DxlCsVKQoMCO-St1Fp3pWIKG9SqkEzLjhVSYqex4WWrQDUcKgReIZdFq1W-ILe_u0Pw7yPGVPcmarQWHPox1jxXrMwLxaoJvTmhY9NjWw_B9BCO9d99-Tf1zm_w</recordid><startdate>2013</startdate><enddate>2013</enddate><creator>Hong, D G</creator><creator>Park, N Y</creator><creator>Chong, G O</creator><creator>Cho, Y L</creator><creator>Park, I S</creator><creator>Jeong, M J</creator><creator>Park, J Y</creator><creator>Lee, Y S</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>2013</creationdate><title>The correlation between expression of synuclein-gamma, glucose transporter-1, and survival outcomes in endometrioid endometrial carcinoma</title><author>Hong, D G ; Park, N Y ; Chong, G O ; Cho, Y L ; Park, I S ; Jeong, M J ; Park, J Y ; Lee, Y S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p211t-7e295abe2efe1d5cccf6707ebec7450c5f0455efceb16d7a7b1a8ea18e154dc73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Carcinoma, Endometrioid - chemistry</topic><topic>Carcinoma, Endometrioid - mortality</topic><topic>Carcinoma, Endometrioid - pathology</topic><topic>Endometrial Neoplasms - chemistry</topic><topic>Endometrial Neoplasms - mortality</topic><topic>Endometrial Neoplasms - pathology</topic><topic>Female</topic><topic>gamma-Synuclein - analysis</topic><topic>Glucose Transporter Type 1 - analysis</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Middle Aged</topic><topic>Neoplasm Proteins - analysis</topic><topic>Neoplasm Staging</topic><topic>Tissue Array Analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hong, D G</creatorcontrib><creatorcontrib>Park, N Y</creatorcontrib><creatorcontrib>Chong, G O</creatorcontrib><creatorcontrib>Cho, Y L</creatorcontrib><creatorcontrib>Park, I S</creatorcontrib><creatorcontrib>Jeong, M J</creatorcontrib><creatorcontrib>Park, J Y</creatorcontrib><creatorcontrib>Lee, Y S</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of gynaecological oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hong, D G</au><au>Park, N Y</au><au>Chong, G O</au><au>Cho, Y L</au><au>Park, I S</au><au>Jeong, M J</au><au>Park, J Y</au><au>Lee, Y S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The correlation between expression of synuclein-gamma, glucose transporter-1, and survival outcomes in endometrioid endometrial carcinoma</atitle><jtitle>European journal of gynaecological oncology</jtitle><addtitle>Eur J Gynaecol Oncol</addtitle><date>2013</date><risdate>2013</risdate><volume>34</volume><issue>2</issue><spage>128</spage><epage>131</epage><pages>128-131</pages><issn>0392-2936</issn><abstract>To evaluate the correlation between immunohistochemical expression of synuclein-gamma, glucose transporter-1, and survival outcomes in endometrioid endometrial carcinoma.
A tissue microarray was constructed using formalinfixed, paraffin-embedded tissue that included 23 early and 18 advanced cases. The intensity and area of the immunohistochemical reactions were evaluated using the semi-quantitative scoring system.
Synuclein-y expression was higher in the advanced stage, although it was not statistically significant (p = 0.51). Glucose transporter-1 was overexpressed in the advanced stage (p = 0.01). Synuclein-gamma (score = 0 vs > 0) and glucose transporter-1 (score < or = 7 vs > 7) did not show any differences in overall survival (p = 0.54, p = 0.48) and disease-free survival (p = 0.61, p = 0.14).
In this study the expression of synuclein-y and glucose transporter-1 were not considered to be a prognostic factor and were not related with survival outcomes in endometrioid endometrial carcinoma.</abstract><cop>Italy</cop><pmid>23781582</pmid><tpages>4</tpages></addata></record> |
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| ispartof | European journal of gynaecological oncology, 2013, Vol.34 (2), p.128-131 |
| issn | 0392-2936 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adult Aged Carcinoma, Endometrioid - chemistry Carcinoma, Endometrioid - mortality Carcinoma, Endometrioid - pathology Endometrial Neoplasms - chemistry Endometrial Neoplasms - mortality Endometrial Neoplasms - pathology Female gamma-Synuclein - analysis Glucose Transporter Type 1 - analysis Humans Immunohistochemistry Middle Aged Neoplasm Proteins - analysis Neoplasm Staging Tissue Array Analysis |
| title | The correlation between expression of synuclein-gamma, glucose transporter-1, and survival outcomes in endometrioid endometrial carcinoma |
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