Dynamic contrast-enhanced MR perfusion imaging of head and neck tumors at 3 Tesla
Background Dynamic contrast‐enhanced (DCE) MR perfusion imaging allows assessment of vascular density and integrity of tumors. The purpose of this study was to determine the diagnostic efficacy of time intensity curve analysis on DCE MRI for characterization of head and neck tumors. Methods Twenty p...
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| Veröffentlicht in: | Head & neck 2013-07, Vol.35 (7), p.923-929 |
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| creator | Furukawa, Matakazu Parvathaneni, Upendra Maravilla, Kenneth Richards, Todd L. Anzai, Yoshimi |
| description | Background
Dynamic contrast‐enhanced (DCE) MR perfusion imaging allows assessment of vascular density and integrity of tumors. The purpose of this study was to determine the diagnostic efficacy of time intensity curve analysis on DCE MRI for characterization of head and neck tumors.
Methods
Twenty patients underwent T1‐weighted fast field echo DCE MRI with temporal resolution of 2.6 seconds. In total, 100 dynamic phases covering 20 slices were obtained in 4.5 minutes. Time to peak (TTP), relative maximum enhancement (RME) ratio, and relative washout ratio (RWO) were calculated.
Results
Malignant tumors had a significantly lower RME (p = .025) and prolonged TTP with lower RWO than benign lesions. Postradiation changes had a significantly longer TTP (p = .024) and lower RWO (p = .007) than did postradiation recurrent tumors. Receiver operating characteristic (ROC) analysis revealed RWO had highest accuracy (area under the curve [AUC] = 1.0).
Conclusions
DCE MR perfusion imaging provides pivotal information regarding microcirculation, potentially improves differentiation of malignant tumor from postradiation changes. © 2012 Wiley Periodicals, Inc. Head Neck, 2013 |
| doi_str_mv | 10.1002/hed.23051 |
| format | Article |
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Dynamic contrast‐enhanced (DCE) MR perfusion imaging allows assessment of vascular density and integrity of tumors. The purpose of this study was to determine the diagnostic efficacy of time intensity curve analysis on DCE MRI for characterization of head and neck tumors.
Methods
Twenty patients underwent T1‐weighted fast field echo DCE MRI with temporal resolution of 2.6 seconds. In total, 100 dynamic phases covering 20 slices were obtained in 4.5 minutes. Time to peak (TTP), relative maximum enhancement (RME) ratio, and relative washout ratio (RWO) were calculated.
Results
Malignant tumors had a significantly lower RME (p = .025) and prolonged TTP with lower RWO than benign lesions. Postradiation changes had a significantly longer TTP (p = .024) and lower RWO (p = .007) than did postradiation recurrent tumors. Receiver operating characteristic (ROC) analysis revealed RWO had highest accuracy (area under the curve [AUC] = 1.0).
Conclusions
DCE MR perfusion imaging provides pivotal information regarding microcirculation, potentially improves differentiation of malignant tumor from postradiation changes. © 2012 Wiley Periodicals, Inc. Head Neck, 2013</description><identifier>ISSN: 1043-3074</identifier><identifier>EISSN: 1097-0347</identifier><identifier>DOI: 10.1002/hed.23051</identifier><identifier>PMID: 22887003</identifier><identifier>CODEN: HEANEE</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adult ; Aged ; Contrast Media ; dynamic contrast enhanced (DCE) ; Female ; Head and Neck Neoplasms - diagnosis ; head and neck tumor ; Humans ; Magnetic Resonance Angiography - methods ; Male ; Middle Aged ; MRI ; perfusion ; postradiation change ; Retrospective Studies ; ROC Curve ; time intensity curve (TIC)</subject><ispartof>Head & neck, 2013-07, Vol.35 (7), p.923-929</ispartof><rights>Copyright © 2012 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4571-efbbd966ac22724e39cde5ec406d4e2f848965d04e7477bdd3f646063d77d29d3</citedby><cites>FETCH-LOGICAL-c4571-efbbd966ac22724e39cde5ec406d4e2f848965d04e7477bdd3f646063d77d29d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fhed.23051$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fhed.23051$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,782,786,1419,27931,27932,45581,45582</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22887003$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Furukawa, Matakazu</creatorcontrib><creatorcontrib>Parvathaneni, Upendra</creatorcontrib><creatorcontrib>Maravilla, Kenneth</creatorcontrib><creatorcontrib>Richards, Todd L.</creatorcontrib><creatorcontrib>Anzai, Yoshimi</creatorcontrib><title>Dynamic contrast-enhanced MR perfusion imaging of head and neck tumors at 3 Tesla</title><title>Head & neck</title><addtitle>Head Neck</addtitle><description>Background
Dynamic contrast‐enhanced (DCE) MR perfusion imaging allows assessment of vascular density and integrity of tumors. The purpose of this study was to determine the diagnostic efficacy of time intensity curve analysis on DCE MRI for characterization of head and neck tumors.
Methods
Twenty patients underwent T1‐weighted fast field echo DCE MRI with temporal resolution of 2.6 seconds. In total, 100 dynamic phases covering 20 slices were obtained in 4.5 minutes. Time to peak (TTP), relative maximum enhancement (RME) ratio, and relative washout ratio (RWO) were calculated.
Results
Malignant tumors had a significantly lower RME (p = .025) and prolonged TTP with lower RWO than benign lesions. Postradiation changes had a significantly longer TTP (p = .024) and lower RWO (p = .007) than did postradiation recurrent tumors. Receiver operating characteristic (ROC) analysis revealed RWO had highest accuracy (area under the curve [AUC] = 1.0).
Conclusions
DCE MR perfusion imaging provides pivotal information regarding microcirculation, potentially improves differentiation of malignant tumor from postradiation changes. © 2012 Wiley Periodicals, Inc. Head Neck, 2013</description><subject>Adult</subject><subject>Aged</subject><subject>Contrast Media</subject><subject>dynamic contrast enhanced (DCE)</subject><subject>Female</subject><subject>Head and Neck Neoplasms - diagnosis</subject><subject>head and neck tumor</subject><subject>Humans</subject><subject>Magnetic Resonance Angiography - methods</subject><subject>Male</subject><subject>Middle Aged</subject><subject>MRI</subject><subject>perfusion</subject><subject>postradiation change</subject><subject>Retrospective Studies</subject><subject>ROC Curve</subject><subject>time intensity curve (TIC)</subject><issn>1043-3074</issn><issn>1097-0347</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10E1LwzAYB_Agiu8Hv4AEvOihM03SZD3K1KlMRZkIXkKWPHXVNp1Ji-7bG53zIHjKC7_nT_JHaC8lvZQQejwF26OMZOkK2kxJLhPCuFz92nOWMCL5BtoK4YUQwgSn62iD0n5fxtMmujudO12XBpvGtV6HNgE31c6Axdf3eAa-6ELZOFzW-rl0z7gp8BS0xdpZ7MC84rarGx-wbjHDYwiV3kFrha4C7P6s2-jh_Gw8uEhGt8PLwckoMTyTaQLFZGJzIbShVFIOLDcWMjCcCMuBFn3ez0VmCQfJpZxYywrBBRHMSmlpbtk2Olzkznzz1kFoVV0GA1WlHTRdUCmTUbNc5JEe_KEvTeddfF1UIpcZyziL6mihjG9C8FComY_f9nOVEvXVs4o9q--eo93_SewmdbxdymWxERwvwHtZwfz_JHVxdrqMTBYTZWjh43dC-1clJJOZerwZqqvx_fXj01Aozj4BQAmUEw</recordid><startdate>201307</startdate><enddate>201307</enddate><creator>Furukawa, Matakazu</creator><creator>Parvathaneni, Upendra</creator><creator>Maravilla, Kenneth</creator><creator>Richards, Todd L.</creator><creator>Anzai, Yoshimi</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201307</creationdate><title>Dynamic contrast-enhanced MR perfusion imaging of head and neck tumors at 3 Tesla</title><author>Furukawa, Matakazu ; Parvathaneni, Upendra ; Maravilla, Kenneth ; Richards, Todd L. ; Anzai, Yoshimi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4571-efbbd966ac22724e39cde5ec406d4e2f848965d04e7477bdd3f646063d77d29d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Contrast Media</topic><topic>dynamic contrast enhanced (DCE)</topic><topic>Female</topic><topic>Head and Neck Neoplasms - diagnosis</topic><topic>head and neck tumor</topic><topic>Humans</topic><topic>Magnetic Resonance Angiography - methods</topic><topic>Male</topic><topic>Middle Aged</topic><topic>MRI</topic><topic>perfusion</topic><topic>postradiation change</topic><topic>Retrospective Studies</topic><topic>ROC Curve</topic><topic>time intensity curve (TIC)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Furukawa, Matakazu</creatorcontrib><creatorcontrib>Parvathaneni, Upendra</creatorcontrib><creatorcontrib>Maravilla, Kenneth</creatorcontrib><creatorcontrib>Richards, Todd L.</creatorcontrib><creatorcontrib>Anzai, Yoshimi</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Head & neck</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Furukawa, Matakazu</au><au>Parvathaneni, Upendra</au><au>Maravilla, Kenneth</au><au>Richards, Todd L.</au><au>Anzai, Yoshimi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dynamic contrast-enhanced MR perfusion imaging of head and neck tumors at 3 Tesla</atitle><jtitle>Head & neck</jtitle><addtitle>Head Neck</addtitle><date>2013-07</date><risdate>2013</risdate><volume>35</volume><issue>7</issue><spage>923</spage><epage>929</epage><pages>923-929</pages><issn>1043-3074</issn><eissn>1097-0347</eissn><coden>HEANEE</coden><abstract>Background
Dynamic contrast‐enhanced (DCE) MR perfusion imaging allows assessment of vascular density and integrity of tumors. The purpose of this study was to determine the diagnostic efficacy of time intensity curve analysis on DCE MRI for characterization of head and neck tumors.
Methods
Twenty patients underwent T1‐weighted fast field echo DCE MRI with temporal resolution of 2.6 seconds. In total, 100 dynamic phases covering 20 slices were obtained in 4.5 minutes. Time to peak (TTP), relative maximum enhancement (RME) ratio, and relative washout ratio (RWO) were calculated.
Results
Malignant tumors had a significantly lower RME (p = .025) and prolonged TTP with lower RWO than benign lesions. Postradiation changes had a significantly longer TTP (p = .024) and lower RWO (p = .007) than did postradiation recurrent tumors. Receiver operating characteristic (ROC) analysis revealed RWO had highest accuracy (area under the curve [AUC] = 1.0).
Conclusions
DCE MR perfusion imaging provides pivotal information regarding microcirculation, potentially improves differentiation of malignant tumor from postradiation changes. © 2012 Wiley Periodicals, Inc. Head Neck, 2013</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>22887003</pmid><doi>10.1002/hed.23051</doi><tpages>7</tpages></addata></record> |
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| source | MEDLINE; Access via Wiley Online Library |
| subjects | Adult Aged Contrast Media dynamic contrast enhanced (DCE) Female Head and Neck Neoplasms - diagnosis head and neck tumor Humans Magnetic Resonance Angiography - methods Male Middle Aged MRI perfusion postradiation change Retrospective Studies ROC Curve time intensity curve (TIC) |
| title | Dynamic contrast-enhanced MR perfusion imaging of head and neck tumors at 3 Tesla |
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