A recurrent CHEK2 p.H371Y mutation is associated with breast cancer risk in Chinese women

The association between the CHEK2 and breast cancer risk in Chinese women is unknown. Here, we screened the full CHEK2 coding sequence in 118 Chinese familial breast cancer cases who are negative for mutations in BRCA1 and BRCA2, one recurrent mutation, CHEK2 c.1111C>T (p.H371Y), was identified i...

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Veröffentlicht in:	Human mutation 2011-09, Vol.32 (9), p.1000-1003
Hauptverfasser:	Liu, Yin, Liao, Ji, Xu, Ye, Chen, Weiqiu, Liu, Dongyun, Ouyang, Tao, Li, Jinfeng, Wang, Tianfeng, Fan, Zhaoqing, Fan, Tie, Lin, Benyao, Xu, Xingzhi, Xie, Yuntao
Format:	Artikel
Sprache:	eng
Schlagworte:	Asian Continental Ancestry Group - genetics BRCA1 protein BRCA2 protein Breast cancer Breast Neoplasms - enzymology Breast Neoplasms - genetics Cancer Case-Control Studies Checkpoint Kinase 2 - genetics CHEK2 China Chinese women familial breast cancer Female Females Functional analysis Genetic Association Studies Genetic Predisposition to Disease Humans Mutation Mutation - genetics p.H371Y Risk Factors
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