Biotin and carnitine profiles in preterm infants in Japan
Background Biotin plays an important role as a covalently bound coenzyme for carboxylases. Carnitine is essential in β‐oxidation to transport long‐chain fatty acids across the inner mitochondrial membrane. The present study was conducted to assess the risk of biotin and carnitine deficiencies in pre...
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| Veröffentlicht in: | Pediatrics international 2013-06, Vol.55 (3), p.342-345 |
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| creator | Tokuriki, Shuko Hayashi, Hisako Okuno, Takashi Yoshioka, Kikuko Okazaki, Shintaro Kawakita, Akiko Ohta, Genrei Hata, Ikue Shigematsu, Yosuke Ohshima, Yusei |
| description | Background
Biotin plays an important role as a covalently bound coenzyme for carboxylases. Carnitine is essential in β‐oxidation to transport long‐chain fatty acids across the inner mitochondrial membrane. The present study was conducted to assess the risk of biotin and carnitine deficiencies in preterm infants who received enteral feeding with maternal milk and/or standard infant formula made in Japan.
Methods
Forty‐six infants were enrolled in the study. Urine and serum samples and dried blood spots were collected at 1 week and 1 month of age. Additionally, samples were collected at 40 and 44 weeks post‐menstrual age (PMA) in preterm infants. Free carnitine and C5‐OH acylcarnitine, which consist of 3‐hydroxyisovalerylcarnitine as a major isomer, were measured in serum samples and dried blood spots using tandem mass spectrometry. Urine 3‐hydroxyisovaleric acid (3‐HIVA) was measured using gas chromatography/mass spectrometry.
Results
The free carnitine levels in preterm infants were significantly lower than those in term infants, but increased with PMA in serum samples and dried blood spots. C5‐OH acylcarnitine and urinary 3‐HIVA levels, which were very low in term infants, were increased with PMA in preterm infants.
Conclusion
The present results may indicate chronic biotin deficiency in preterm infants fed maternal milk and/or standard infant formula. Analyses of carnitine profiles of dried blood spots and urine 3‐HIVA are relatively non‐invasive and useful for the early detection of biotin deficiency in preterm infants. |
| doi_str_mv | 10.1111/ped.12053 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_1370633151</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2998747831</sourcerecordid><originalsourceid>FETCH-LOGICAL-i3833-a38534aff8bb2ad81d191e52e1badc3db62d9b0c79ffe81a828c09da7c16b62d3</originalsourceid><addsrcrecordid>eNpdkMlOwzAYhC0EoqVw4AVQJC5c0npJbOcIXUEVO6I3y4kdySVJg50I-va4CxzwxWPPN9bvAeAcwT7ya1Br1UcYxuQAdFEU4RBDuDj0mmAeckhZB5w4t4QQcsajY9DBhCDKSdwFyY1ZNaYKZKWCTNrK-IMOarvKTaFd4J3a6kbb0stcVs326k7WsjoFR7ksnD7b7z3wNhm_Dmfh_GF6O7yeh4ZwQkJJeEwimec8TbFUHCmUIB1jjVKpMqJSilWSwowlea45khzzDCZKsgzRjUd64Gr3rh_qs9WuEaVxmS4KWelV6wQiDFL_nxh59PIfuly1tvLTeYomBHLKmKcu9lSbllqJ2ppS2rX4LcUDgx3w5TtY__kIik3bwrcttm2Lx_FoK3wi3CWMa_T3X0LaD0EZYbF4v5-K2dPkZbqYjcQz-QEwJH9z</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1369308677</pqid></control><display><type>article</type><title>Biotin and carnitine profiles in preterm infants in Japan</title><source>MEDLINE</source><source>Wiley Online Library All Journals</source><creator>Tokuriki, Shuko ; Hayashi, Hisako ; Okuno, Takashi ; Yoshioka, Kikuko ; Okazaki, Shintaro ; Kawakita, Akiko ; Ohta, Genrei ; Hata, Ikue ; Shigematsu, Yosuke ; Ohshima, Yusei</creator><creatorcontrib>Tokuriki, Shuko ; Hayashi, Hisako ; Okuno, Takashi ; Yoshioka, Kikuko ; Okazaki, Shintaro ; Kawakita, Akiko ; Ohta, Genrei ; Hata, Ikue ; Shigematsu, Yosuke ; Ohshima, Yusei</creatorcontrib><description>Background
Biotin plays an important role as a covalently bound coenzyme for carboxylases. Carnitine is essential in β‐oxidation to transport long‐chain fatty acids across the inner mitochondrial membrane. The present study was conducted to assess the risk of biotin and carnitine deficiencies in preterm infants who received enteral feeding with maternal milk and/or standard infant formula made in Japan.
Methods
Forty‐six infants were enrolled in the study. Urine and serum samples and dried blood spots were collected at 1 week and 1 month of age. Additionally, samples were collected at 40 and 44 weeks post‐menstrual age (PMA) in preterm infants. Free carnitine and C5‐OH acylcarnitine, which consist of 3‐hydroxyisovalerylcarnitine as a major isomer, were measured in serum samples and dried blood spots using tandem mass spectrometry. Urine 3‐hydroxyisovaleric acid (3‐HIVA) was measured using gas chromatography/mass spectrometry.
Results
The free carnitine levels in preterm infants were significantly lower than those in term infants, but increased with PMA in serum samples and dried blood spots. C5‐OH acylcarnitine and urinary 3‐HIVA levels, which were very low in term infants, were increased with PMA in preterm infants.
Conclusion
The present results may indicate chronic biotin deficiency in preterm infants fed maternal milk and/or standard infant formula. Analyses of carnitine profiles of dried blood spots and urine 3‐HIVA are relatively non‐invasive and useful for the early detection of biotin deficiency in preterm infants.</description><identifier>ISSN: 1328-8067</identifier><identifier>EISSN: 1442-200X</identifier><identifier>DOI: 10.1111/ped.12053</identifier><identifier>PMID: 23316835</identifier><language>eng</language><publisher>Australia: Blackwell Publishing Ltd</publisher><subject>3-hydroxyisovaleric acid ; Baby foods ; Biochemistry ; biotin ; Biotin - blood ; Biotin - deficiency ; Breastfeeding & lactation ; carnitine ; Carnitine - blood ; Carnitine - deficiency ; Dried Blood Spot Testing ; Enteral Nutrition ; Female ; Gestational Age ; Humans ; infant formula ; Infant, Low Birth Weight ; Infant, Newborn ; Infant, Premature, Diseases - blood ; Intensive Care Units, Neonatal ; Japan ; Male ; Milk, Human ; Pediatrics ; Premature birth ; preterm infant ; Reference Values</subject><ispartof>Pediatrics international, 2013-06, Vol.55 (3), p.342-345</ispartof><rights>2013 The Authors. Pediatrics International © 2013 Japan Pediatric Society</rights><rights>2013 The Authors. Pediatrics International © 2013 Japan Pediatric Society.</rights><rights>Pediatrics International © 2013 Japan Pediatric Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fped.12053$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fped.12053$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23316835$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tokuriki, Shuko</creatorcontrib><creatorcontrib>Hayashi, Hisako</creatorcontrib><creatorcontrib>Okuno, Takashi</creatorcontrib><creatorcontrib>Yoshioka, Kikuko</creatorcontrib><creatorcontrib>Okazaki, Shintaro</creatorcontrib><creatorcontrib>Kawakita, Akiko</creatorcontrib><creatorcontrib>Ohta, Genrei</creatorcontrib><creatorcontrib>Hata, Ikue</creatorcontrib><creatorcontrib>Shigematsu, Yosuke</creatorcontrib><creatorcontrib>Ohshima, Yusei</creatorcontrib><title>Biotin and carnitine profiles in preterm infants in Japan</title><title>Pediatrics international</title><addtitle>Pediatr Int</addtitle><description>Background
Biotin plays an important role as a covalently bound coenzyme for carboxylases. Carnitine is essential in β‐oxidation to transport long‐chain fatty acids across the inner mitochondrial membrane. The present study was conducted to assess the risk of biotin and carnitine deficiencies in preterm infants who received enteral feeding with maternal milk and/or standard infant formula made in Japan.
Methods
Forty‐six infants were enrolled in the study. Urine and serum samples and dried blood spots were collected at 1 week and 1 month of age. Additionally, samples were collected at 40 and 44 weeks post‐menstrual age (PMA) in preterm infants. Free carnitine and C5‐OH acylcarnitine, which consist of 3‐hydroxyisovalerylcarnitine as a major isomer, were measured in serum samples and dried blood spots using tandem mass spectrometry. Urine 3‐hydroxyisovaleric acid (3‐HIVA) was measured using gas chromatography/mass spectrometry.
Results
The free carnitine levels in preterm infants were significantly lower than those in term infants, but increased with PMA in serum samples and dried blood spots. C5‐OH acylcarnitine and urinary 3‐HIVA levels, which were very low in term infants, were increased with PMA in preterm infants.
Conclusion
The present results may indicate chronic biotin deficiency in preterm infants fed maternal milk and/or standard infant formula. Analyses of carnitine profiles of dried blood spots and urine 3‐HIVA are relatively non‐invasive and useful for the early detection of biotin deficiency in preterm infants.</description><subject>3-hydroxyisovaleric acid</subject><subject>Baby foods</subject><subject>Biochemistry</subject><subject>biotin</subject><subject>Biotin - blood</subject><subject>Biotin - deficiency</subject><subject>Breastfeeding & lactation</subject><subject>carnitine</subject><subject>Carnitine - blood</subject><subject>Carnitine - deficiency</subject><subject>Dried Blood Spot Testing</subject><subject>Enteral Nutrition</subject><subject>Female</subject><subject>Gestational Age</subject><subject>Humans</subject><subject>infant formula</subject><subject>Infant, Low Birth Weight</subject><subject>Infant, Newborn</subject><subject>Infant, Premature, Diseases - blood</subject><subject>Intensive Care Units, Neonatal</subject><subject>Japan</subject><subject>Male</subject><subject>Milk, Human</subject><subject>Pediatrics</subject><subject>Premature birth</subject><subject>preterm infant</subject><subject>Reference Values</subject><issn>1328-8067</issn><issn>1442-200X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkMlOwzAYhC0EoqVw4AVQJC5c0npJbOcIXUEVO6I3y4kdySVJg50I-va4CxzwxWPPN9bvAeAcwT7ya1Br1UcYxuQAdFEU4RBDuDj0mmAeckhZB5w4t4QQcsajY9DBhCDKSdwFyY1ZNaYKZKWCTNrK-IMOarvKTaFd4J3a6kbb0stcVs326k7WsjoFR7ksnD7b7z3wNhm_Dmfh_GF6O7yeh4ZwQkJJeEwimec8TbFUHCmUIB1jjVKpMqJSilWSwowlea45khzzDCZKsgzRjUd64Gr3rh_qs9WuEaVxmS4KWelV6wQiDFL_nxh59PIfuly1tvLTeYomBHLKmKcu9lSbllqJ2ppS2rX4LcUDgx3w5TtY__kIik3bwrcttm2Lx_FoK3wi3CWMa_T3X0LaD0EZYbF4v5-K2dPkZbqYjcQz-QEwJH9z</recordid><startdate>201306</startdate><enddate>201306</enddate><creator>Tokuriki, Shuko</creator><creator>Hayashi, Hisako</creator><creator>Okuno, Takashi</creator><creator>Yoshioka, Kikuko</creator><creator>Okazaki, Shintaro</creator><creator>Kawakita, Akiko</creator><creator>Ohta, Genrei</creator><creator>Hata, Ikue</creator><creator>Shigematsu, Yosuke</creator><creator>Ohshima, Yusei</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7TK</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201306</creationdate><title>Biotin and carnitine profiles in preterm infants in Japan</title><author>Tokuriki, Shuko ; Hayashi, Hisako ; Okuno, Takashi ; Yoshioka, Kikuko ; Okazaki, Shintaro ; Kawakita, Akiko ; Ohta, Genrei ; Hata, Ikue ; Shigematsu, Yosuke ; Ohshima, Yusei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i3833-a38534aff8bb2ad81d191e52e1badc3db62d9b0c79ffe81a828c09da7c16b62d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>3-hydroxyisovaleric acid</topic><topic>Baby foods</topic><topic>Biochemistry</topic><topic>biotin</topic><topic>Biotin - blood</topic><topic>Biotin - deficiency</topic><topic>Breastfeeding & lactation</topic><topic>carnitine</topic><topic>Carnitine - blood</topic><topic>Carnitine - deficiency</topic><topic>Dried Blood Spot Testing</topic><topic>Enteral Nutrition</topic><topic>Female</topic><topic>Gestational Age</topic><topic>Humans</topic><topic>infant formula</topic><topic>Infant, Low Birth Weight</topic><topic>Infant, Newborn</topic><topic>Infant, Premature, Diseases - blood</topic><topic>Intensive Care Units, Neonatal</topic><topic>Japan</topic><topic>Male</topic><topic>Milk, Human</topic><topic>Pediatrics</topic><topic>Premature birth</topic><topic>preterm infant</topic><topic>Reference Values</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tokuriki, Shuko</creatorcontrib><creatorcontrib>Hayashi, Hisako</creatorcontrib><creatorcontrib>Okuno, Takashi</creatorcontrib><creatorcontrib>Yoshioka, Kikuko</creatorcontrib><creatorcontrib>Okazaki, Shintaro</creatorcontrib><creatorcontrib>Kawakita, Akiko</creatorcontrib><creatorcontrib>Ohta, Genrei</creatorcontrib><creatorcontrib>Hata, Ikue</creatorcontrib><creatorcontrib>Shigematsu, Yosuke</creatorcontrib><creatorcontrib>Ohshima, Yusei</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatrics international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tokuriki, Shuko</au><au>Hayashi, Hisako</au><au>Okuno, Takashi</au><au>Yoshioka, Kikuko</au><au>Okazaki, Shintaro</au><au>Kawakita, Akiko</au><au>Ohta, Genrei</au><au>Hata, Ikue</au><au>Shigematsu, Yosuke</au><au>Ohshima, Yusei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Biotin and carnitine profiles in preterm infants in Japan</atitle><jtitle>Pediatrics international</jtitle><addtitle>Pediatr Int</addtitle><date>2013-06</date><risdate>2013</risdate><volume>55</volume><issue>3</issue><spage>342</spage><epage>345</epage><pages>342-345</pages><issn>1328-8067</issn><eissn>1442-200X</eissn><abstract>Background
Biotin plays an important role as a covalently bound coenzyme for carboxylases. Carnitine is essential in β‐oxidation to transport long‐chain fatty acids across the inner mitochondrial membrane. The present study was conducted to assess the risk of biotin and carnitine deficiencies in preterm infants who received enteral feeding with maternal milk and/or standard infant formula made in Japan.
Methods
Forty‐six infants were enrolled in the study. Urine and serum samples and dried blood spots were collected at 1 week and 1 month of age. Additionally, samples were collected at 40 and 44 weeks post‐menstrual age (PMA) in preterm infants. Free carnitine and C5‐OH acylcarnitine, which consist of 3‐hydroxyisovalerylcarnitine as a major isomer, were measured in serum samples and dried blood spots using tandem mass spectrometry. Urine 3‐hydroxyisovaleric acid (3‐HIVA) was measured using gas chromatography/mass spectrometry.
Results
The free carnitine levels in preterm infants were significantly lower than those in term infants, but increased with PMA in serum samples and dried blood spots. C5‐OH acylcarnitine and urinary 3‐HIVA levels, which were very low in term infants, were increased with PMA in preterm infants.
Conclusion
The present results may indicate chronic biotin deficiency in preterm infants fed maternal milk and/or standard infant formula. Analyses of carnitine profiles of dried blood spots and urine 3‐HIVA are relatively non‐invasive and useful for the early detection of biotin deficiency in preterm infants.</abstract><cop>Australia</cop><pub>Blackwell Publishing Ltd</pub><pmid>23316835</pmid><doi>10.1111/ped.12053</doi><tpages>4</tpages></addata></record> |
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| identifier | ISSN: 1328-8067 |
| ispartof | Pediatrics international, 2013-06, Vol.55 (3), p.342-345 |
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| subjects | 3-hydroxyisovaleric acid Baby foods Biochemistry biotin Biotin - blood Biotin - deficiency Breastfeeding & lactation carnitine Carnitine - blood Carnitine - deficiency Dried Blood Spot Testing Enteral Nutrition Female Gestational Age Humans infant formula Infant, Low Birth Weight Infant, Newborn Infant, Premature, Diseases - blood Intensive Care Units, Neonatal Japan Male Milk, Human Pediatrics Premature birth preterm infant Reference Values |
| title | Biotin and carnitine profiles in preterm infants in Japan |
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