Factors associated with specific clinical forms of oral candidiasis in HIV-infected Brazilian adults

Abstract Objective This study assesses the association among factors related with specific clinical forms of oral candidiasis (OC) in HIV-infected Brazilian adults. Design This study was conducted with 590 HIV-infected adults from 1997 to 2004. The OC diagnosis was based in accordance with the EC-Cl...

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Veröffentlicht in:Archives of oral biology 2013-06, Vol.58 (6), p.657-663
Hauptverfasser: Gonçalves, Lucio Souza, Silva, Arley, Ferreira, Sônia Maria Soares, Sousa, Celso Oliveira, Fontes, Tatiana Vasconcellos, Vettore, Mario Vianna, Torres, Sandra Regina
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container_end_page 663
container_issue 6
container_start_page 657
container_title Archives of oral biology
container_volume 58
creator Gonçalves, Lucio Souza
Silva, Arley
Ferreira, Sônia Maria Soares
Sousa, Celso Oliveira
Fontes, Tatiana Vasconcellos
Vettore, Mario Vianna
Torres, Sandra Regina
description Abstract Objective This study assesses the association among factors related with specific clinical forms of oral candidiasis (OC) in HIV-infected Brazilian adults. Design This study was conducted with 590 HIV-infected adults from 1997 to 2004. The OC diagnosis was based in accordance with the EC-Clearinghouse classification. Multivariate logistic regression analyses were performed to measure the association between HAART and OC, with pseudomembranous [PC], erythematous [EC], and angular cheilitis [AC]) adjusted for HIV-related diseases, smoking, alcohol consumption, injecting and non-injecting drug use. Results Two hundred and eighteen (37.0%) individuals were undergoing HAART. The prevalence of PC, EC and AC was 21.2%, 15.7% and 8.8%, respectively. Approximately 64% of the individuals with PC and EC, and 76.5% with AC had absolute CD4 levels ≤200 cells/mm3 . The results of the multivariate analysis showed that subjects not undergoing HAART had a significantly higher odds ratio for PC [OR 3.67 (95% CI: 1.97–6.80)] and EC [OR 1.88 (95% CI: 1.04–3.39)], and AC [OR 4.56 (95% CI: 1.58–13.19)]. In addition, smoking [OR 2.58 (95% CI: 1.43–4.68)] and pneumocystis pneumonia [OR 1.92 (95% CI: 1.07–3.42)] were associated with PC, while high alcohol consumption [OR 3.40 (95% CI: 1.13–10.18)] and cytomegalovirus infection [OR 2.34 (95% CI: 1.06–5.15)] were associated with EC. Conclusion The data indicates that the odds of having all clinical forms of OC are higher in HIV-infected adults not receiving HAART.
doi_str_mv 10.1016/j.archoralbio.2012.10.007
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Design This study was conducted with 590 HIV-infected adults from 1997 to 2004. The OC diagnosis was based in accordance with the EC-Clearinghouse classification. Multivariate logistic regression analyses were performed to measure the association between HAART and OC, with pseudomembranous [PC], erythematous [EC], and angular cheilitis [AC]) adjusted for HIV-related diseases, smoking, alcohol consumption, injecting and non-injecting drug use. Results Two hundred and eighteen (37.0%) individuals were undergoing HAART. The prevalence of PC, EC and AC was 21.2%, 15.7% and 8.8%, respectively. Approximately 64% of the individuals with PC and EC, and 76.5% with AC had absolute CD4 levels ≤200 cells/mm3 . The results of the multivariate analysis showed that subjects not undergoing HAART had a significantly higher odds ratio for PC [OR 3.67 (95% CI: 1.97–6.80)] and EC [OR 1.88 (95% CI: 1.04–3.39)], and AC [OR 4.56 (95% CI: 1.58–13.19)]. In addition, smoking [OR 2.58 (95% CI: 1.43–4.68)] and pneumocystis pneumonia [OR 1.92 (95% CI: 1.07–3.42)] were associated with PC, while high alcohol consumption [OR 3.40 (95% CI: 1.13–10.18)] and cytomegalovirus infection [OR 2.34 (95% CI: 1.06–5.15)] were associated with EC. Conclusion The data indicates that the odds of having all clinical forms of OC are higher in HIV-infected adults not receiving HAART.</description><identifier>ISSN: 0003-9969</identifier><identifier>EISSN: 1879-1506</identifier><identifier>DOI: 10.1016/j.archoralbio.2012.10.007</identifier><identifier>PMID: 23123068</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Adult ; Advanced Basic Science ; AIDS-Related Opportunistic Infections - diagnosis ; Alcohol Drinking ; Antiretroviral Therapy, Highly Active ; Brazil ; Candidiasis, Oral - diagnosis ; CD4 Lymphocyte Count ; Cheilitis - diagnosis ; Cross-Sectional Studies ; Cytomegalovirus Infections - diagnosis ; Dentistry ; Educational Status ; Female ; Highly active antiretroviral therapy ; HIV infection ; HIV Infections - complications ; HIV Infections - drug therapy ; Humans ; Income ; Male ; Middle Aged ; Oral candidiasis ; Pneumonia, Pneumocystis - diagnosis ; Sarcoma, Kaposi - diagnosis ; Smoking ; Substance Abuse, Intravenous - complications ; Substance-Related Disorders - complications ; Toxoplasmosis - diagnosis ; Tuberculosis - diagnosis ; Young Adult</subject><ispartof>Archives of oral biology, 2013-06, Vol.58 (6), p.657-663</ispartof><rights>Elsevier Ltd</rights><rights>2012 Elsevier Ltd</rights><rights>Copyright © 2012 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c432t-12941bead63d99ce6accceb562eef241870dd144491c644c4da6cb48415d13be3</citedby><cites>FETCH-LOGICAL-c432t-12941bead63d99ce6accceb562eef241870dd144491c644c4da6cb48415d13be3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0003996912003500$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27903,27904,65308</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23123068$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gonçalves, Lucio Souza</creatorcontrib><creatorcontrib>Silva, Arley</creatorcontrib><creatorcontrib>Ferreira, Sônia Maria Soares</creatorcontrib><creatorcontrib>Sousa, Celso Oliveira</creatorcontrib><creatorcontrib>Fontes, Tatiana Vasconcellos</creatorcontrib><creatorcontrib>Vettore, Mario Vianna</creatorcontrib><creatorcontrib>Torres, Sandra Regina</creatorcontrib><title>Factors associated with specific clinical forms of oral candidiasis in HIV-infected Brazilian adults</title><title>Archives of oral biology</title><addtitle>Arch Oral Biol</addtitle><description>Abstract Objective This study assesses the association among factors related with specific clinical forms of oral candidiasis (OC) in HIV-infected Brazilian adults. Design This study was conducted with 590 HIV-infected adults from 1997 to 2004. The OC diagnosis was based in accordance with the EC-Clearinghouse classification. Multivariate logistic regression analyses were performed to measure the association between HAART and OC, with pseudomembranous [PC], erythematous [EC], and angular cheilitis [AC]) adjusted for HIV-related diseases, smoking, alcohol consumption, injecting and non-injecting drug use. Results Two hundred and eighteen (37.0%) individuals were undergoing HAART. The prevalence of PC, EC and AC was 21.2%, 15.7% and 8.8%, respectively. Approximately 64% of the individuals with PC and EC, and 76.5% with AC had absolute CD4 levels ≤200 cells/mm3 . The results of the multivariate analysis showed that subjects not undergoing HAART had a significantly higher odds ratio for PC [OR 3.67 (95% CI: 1.97–6.80)] and EC [OR 1.88 (95% CI: 1.04–3.39)], and AC [OR 4.56 (95% CI: 1.58–13.19)]. In addition, smoking [OR 2.58 (95% CI: 1.43–4.68)] and pneumocystis pneumonia [OR 1.92 (95% CI: 1.07–3.42)] were associated with PC, while high alcohol consumption [OR 3.40 (95% CI: 1.13–10.18)] and cytomegalovirus infection [OR 2.34 (95% CI: 1.06–5.15)] were associated with EC. Conclusion The data indicates that the odds of having all clinical forms of OC are higher in HIV-infected adults not receiving HAART.</description><subject>Adult</subject><subject>Advanced Basic Science</subject><subject>AIDS-Related Opportunistic Infections - diagnosis</subject><subject>Alcohol Drinking</subject><subject>Antiretroviral Therapy, Highly Active</subject><subject>Brazil</subject><subject>Candidiasis, Oral - diagnosis</subject><subject>CD4 Lymphocyte Count</subject><subject>Cheilitis - diagnosis</subject><subject>Cross-Sectional Studies</subject><subject>Cytomegalovirus Infections - diagnosis</subject><subject>Dentistry</subject><subject>Educational Status</subject><subject>Female</subject><subject>Highly active antiretroviral therapy</subject><subject>HIV infection</subject><subject>HIV Infections - complications</subject><subject>HIV Infections - drug therapy</subject><subject>Humans</subject><subject>Income</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Oral candidiasis</subject><subject>Pneumonia, Pneumocystis - diagnosis</subject><subject>Sarcoma, Kaposi - diagnosis</subject><subject>Smoking</subject><subject>Substance Abuse, Intravenous - complications</subject><subject>Substance-Related Disorders - complications</subject><subject>Toxoplasmosis - diagnosis</subject><subject>Tuberculosis - diagnosis</subject><subject>Young Adult</subject><issn>0003-9969</issn><issn>1879-1506</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU1v1DAQhi0EokvhLyBz45LFdhzv5oIEK0orVeLAx9VyxhN1lmy8eJKi8utxtC1CnDhY_nrnfTXPCPFKq7VW2r3Zr0OGm5TD0FFaG6VNeV8rtXkkVnq7aSvdKPdYrJRSddW2rj0Tz5j35do4p5-KM1NrUyu3XYl4EWBKmWVgTkBhwih_0nQj-YhAPYGEgUaCMMg-5QPL1MslWEIYI0UKTCxplJdX3yoae4TF4H0Ov2igMMoQ52Hi5-JJHwbGF_f7ufh68eHL7rK6_vTxavfuugJbm6nSprW6wxBdHdsW0AUAwK5xBrE3tnSmYtTW2laDsxZsDA46u7W6ibrusD4Xr0--x5x-zMiTPxADDkMYMc3sdb1RrjbFsEjbkxRyYs7Y-2OmQ8h3Xiu_QPZ7_xdkv0BevgrkUvvyPmbuDhj_VD5QLYLdSYCl2VvC7BkIR8BIuRDyMdF_xbz9x-VhFN_xDnmf5jwWml57Nl75z8u0l2FrUw5NWb8BkKCpoQ</recordid><startdate>20130601</startdate><enddate>20130601</enddate><creator>Gonçalves, Lucio Souza</creator><creator>Silva, Arley</creator><creator>Ferreira, Sônia Maria Soares</creator><creator>Sousa, Celso Oliveira</creator><creator>Fontes, Tatiana Vasconcellos</creator><creator>Vettore, Mario Vianna</creator><creator>Torres, Sandra Regina</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20130601</creationdate><title>Factors associated with specific clinical forms of oral candidiasis in HIV-infected Brazilian adults</title><author>Gonçalves, Lucio Souza ; Silva, Arley ; Ferreira, Sônia Maria Soares ; Sousa, Celso Oliveira ; Fontes, Tatiana Vasconcellos ; Vettore, Mario Vianna ; Torres, Sandra Regina</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c432t-12941bead63d99ce6accceb562eef241870dd144491c644c4da6cb48415d13be3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Advanced Basic Science</topic><topic>AIDS-Related Opportunistic Infections - diagnosis</topic><topic>Alcohol Drinking</topic><topic>Antiretroviral Therapy, Highly Active</topic><topic>Brazil</topic><topic>Candidiasis, Oral - diagnosis</topic><topic>CD4 Lymphocyte Count</topic><topic>Cheilitis - diagnosis</topic><topic>Cross-Sectional Studies</topic><topic>Cytomegalovirus Infections - diagnosis</topic><topic>Dentistry</topic><topic>Educational Status</topic><topic>Female</topic><topic>Highly active antiretroviral therapy</topic><topic>HIV infection</topic><topic>HIV Infections - complications</topic><topic>HIV Infections - drug therapy</topic><topic>Humans</topic><topic>Income</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Oral candidiasis</topic><topic>Pneumonia, Pneumocystis - diagnosis</topic><topic>Sarcoma, Kaposi - diagnosis</topic><topic>Smoking</topic><topic>Substance Abuse, Intravenous - complications</topic><topic>Substance-Related Disorders - complications</topic><topic>Toxoplasmosis - diagnosis</topic><topic>Tuberculosis - diagnosis</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gonçalves, Lucio Souza</creatorcontrib><creatorcontrib>Silva, Arley</creatorcontrib><creatorcontrib>Ferreira, Sônia Maria Soares</creatorcontrib><creatorcontrib>Sousa, Celso Oliveira</creatorcontrib><creatorcontrib>Fontes, Tatiana Vasconcellos</creatorcontrib><creatorcontrib>Vettore, Mario Vianna</creatorcontrib><creatorcontrib>Torres, Sandra Regina</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of oral biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gonçalves, Lucio Souza</au><au>Silva, Arley</au><au>Ferreira, Sônia Maria Soares</au><au>Sousa, Celso Oliveira</au><au>Fontes, Tatiana Vasconcellos</au><au>Vettore, Mario Vianna</au><au>Torres, Sandra Regina</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Factors associated with specific clinical forms of oral candidiasis in HIV-infected Brazilian adults</atitle><jtitle>Archives of oral biology</jtitle><addtitle>Arch Oral Biol</addtitle><date>2013-06-01</date><risdate>2013</risdate><volume>58</volume><issue>6</issue><spage>657</spage><epage>663</epage><pages>657-663</pages><issn>0003-9969</issn><eissn>1879-1506</eissn><abstract>Abstract Objective This study assesses the association among factors related with specific clinical forms of oral candidiasis (OC) in HIV-infected Brazilian adults. Design This study was conducted with 590 HIV-infected adults from 1997 to 2004. The OC diagnosis was based in accordance with the EC-Clearinghouse classification. Multivariate logistic regression analyses were performed to measure the association between HAART and OC, with pseudomembranous [PC], erythematous [EC], and angular cheilitis [AC]) adjusted for HIV-related diseases, smoking, alcohol consumption, injecting and non-injecting drug use. Results Two hundred and eighteen (37.0%) individuals were undergoing HAART. The prevalence of PC, EC and AC was 21.2%, 15.7% and 8.8%, respectively. Approximately 64% of the individuals with PC and EC, and 76.5% with AC had absolute CD4 levels ≤200 cells/mm3 . The results of the multivariate analysis showed that subjects not undergoing HAART had a significantly higher odds ratio for PC [OR 3.67 (95% CI: 1.97–6.80)] and EC [OR 1.88 (95% CI: 1.04–3.39)], and AC [OR 4.56 (95% CI: 1.58–13.19)]. In addition, smoking [OR 2.58 (95% CI: 1.43–4.68)] and pneumocystis pneumonia [OR 1.92 (95% CI: 1.07–3.42)] were associated with PC, while high alcohol consumption [OR 3.40 (95% CI: 1.13–10.18)] and cytomegalovirus infection [OR 2.34 (95% CI: 1.06–5.15)] were associated with EC. Conclusion The data indicates that the odds of having all clinical forms of OC are higher in HIV-infected adults not receiving HAART.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>23123068</pmid><doi>10.1016/j.archoralbio.2012.10.007</doi><tpages>7</tpages></addata></record>
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subjects Adult
Advanced Basic Science
AIDS-Related Opportunistic Infections - diagnosis
Alcohol Drinking
Antiretroviral Therapy, Highly Active
Brazil
Candidiasis, Oral - diagnosis
CD4 Lymphocyte Count
Cheilitis - diagnosis
Cross-Sectional Studies
Cytomegalovirus Infections - diagnosis
Dentistry
Educational Status
Female
Highly active antiretroviral therapy
HIV infection
HIV Infections - complications
HIV Infections - drug therapy
Humans
Income
Male
Middle Aged
Oral candidiasis
Pneumonia, Pneumocystis - diagnosis
Sarcoma, Kaposi - diagnosis
Smoking
Substance Abuse, Intravenous - complications
Substance-Related Disorders - complications
Toxoplasmosis - diagnosis
Tuberculosis - diagnosis
Young Adult
title Factors associated with specific clinical forms of oral candidiasis in HIV-infected Brazilian adults
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