Factors associated with specific clinical forms of oral candidiasis in HIV-infected Brazilian adults
Abstract Objective This study assesses the association among factors related with specific clinical forms of oral candidiasis (OC) in HIV-infected Brazilian adults. Design This study was conducted with 590 HIV-infected adults from 1997 to 2004. The OC diagnosis was based in accordance with the EC-Cl...
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Veröffentlicht in: | Archives of oral biology 2013-06, Vol.58 (6), p.657-663 |
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description | Abstract Objective This study assesses the association among factors related with specific clinical forms of oral candidiasis (OC) in HIV-infected Brazilian adults. Design This study was conducted with 590 HIV-infected adults from 1997 to 2004. The OC diagnosis was based in accordance with the EC-Clearinghouse classification. Multivariate logistic regression analyses were performed to measure the association between HAART and OC, with pseudomembranous [PC], erythematous [EC], and angular cheilitis [AC]) adjusted for HIV-related diseases, smoking, alcohol consumption, injecting and non-injecting drug use. Results Two hundred and eighteen (37.0%) individuals were undergoing HAART. The prevalence of PC, EC and AC was 21.2%, 15.7% and 8.8%, respectively. Approximately 64% of the individuals with PC and EC, and 76.5% with AC had absolute CD4 levels ≤200 cells/mm3 . The results of the multivariate analysis showed that subjects not undergoing HAART had a significantly higher odds ratio for PC [OR 3.67 (95% CI: 1.97–6.80)] and EC [OR 1.88 (95% CI: 1.04–3.39)], and AC [OR 4.56 (95% CI: 1.58–13.19)]. In addition, smoking [OR 2.58 (95% CI: 1.43–4.68)] and pneumocystis pneumonia [OR 1.92 (95% CI: 1.07–3.42)] were associated with PC, while high alcohol consumption [OR 3.40 (95% CI: 1.13–10.18)] and cytomegalovirus infection [OR 2.34 (95% CI: 1.06–5.15)] were associated with EC. Conclusion The data indicates that the odds of having all clinical forms of OC are higher in HIV-infected adults not receiving HAART. |
doi_str_mv | 10.1016/j.archoralbio.2012.10.007 |
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Design This study was conducted with 590 HIV-infected adults from 1997 to 2004. The OC diagnosis was based in accordance with the EC-Clearinghouse classification. Multivariate logistic regression analyses were performed to measure the association between HAART and OC, with pseudomembranous [PC], erythematous [EC], and angular cheilitis [AC]) adjusted for HIV-related diseases, smoking, alcohol consumption, injecting and non-injecting drug use. Results Two hundred and eighteen (37.0%) individuals were undergoing HAART. The prevalence of PC, EC and AC was 21.2%, 15.7% and 8.8%, respectively. Approximately 64% of the individuals with PC and EC, and 76.5% with AC had absolute CD4 levels ≤200 cells/mm3 . The results of the multivariate analysis showed that subjects not undergoing HAART had a significantly higher odds ratio for PC [OR 3.67 (95% CI: 1.97–6.80)] and EC [OR 1.88 (95% CI: 1.04–3.39)], and AC [OR 4.56 (95% CI: 1.58–13.19)]. In addition, smoking [OR 2.58 (95% CI: 1.43–4.68)] and pneumocystis pneumonia [OR 1.92 (95% CI: 1.07–3.42)] were associated with PC, while high alcohol consumption [OR 3.40 (95% CI: 1.13–10.18)] and cytomegalovirus infection [OR 2.34 (95% CI: 1.06–5.15)] were associated with EC. Conclusion The data indicates that the odds of having all clinical forms of OC are higher in HIV-infected adults not receiving HAART.</description><identifier>ISSN: 0003-9969</identifier><identifier>EISSN: 1879-1506</identifier><identifier>DOI: 10.1016/j.archoralbio.2012.10.007</identifier><identifier>PMID: 23123068</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Adult ; Advanced Basic Science ; AIDS-Related Opportunistic Infections - diagnosis ; Alcohol Drinking ; Antiretroviral Therapy, Highly Active ; Brazil ; Candidiasis, Oral - diagnosis ; CD4 Lymphocyte Count ; Cheilitis - diagnosis ; Cross-Sectional Studies ; Cytomegalovirus Infections - diagnosis ; Dentistry ; Educational Status ; Female ; Highly active antiretroviral therapy ; HIV infection ; HIV Infections - complications ; HIV Infections - drug therapy ; Humans ; Income ; Male ; Middle Aged ; Oral candidiasis ; Pneumonia, Pneumocystis - diagnosis ; Sarcoma, Kaposi - diagnosis ; Smoking ; Substance Abuse, Intravenous - complications ; Substance-Related Disorders - complications ; Toxoplasmosis - diagnosis ; Tuberculosis - diagnosis ; Young Adult</subject><ispartof>Archives of oral biology, 2013-06, Vol.58 (6), p.657-663</ispartof><rights>Elsevier Ltd</rights><rights>2012 Elsevier Ltd</rights><rights>Copyright © 2012 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c432t-12941bead63d99ce6accceb562eef241870dd144491c644c4da6cb48415d13be3</citedby><cites>FETCH-LOGICAL-c432t-12941bead63d99ce6accceb562eef241870dd144491c644c4da6cb48415d13be3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0003996912003500$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27903,27904,65308</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23123068$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gonçalves, Lucio Souza</creatorcontrib><creatorcontrib>Silva, Arley</creatorcontrib><creatorcontrib>Ferreira, Sônia Maria Soares</creatorcontrib><creatorcontrib>Sousa, Celso Oliveira</creatorcontrib><creatorcontrib>Fontes, Tatiana Vasconcellos</creatorcontrib><creatorcontrib>Vettore, Mario Vianna</creatorcontrib><creatorcontrib>Torres, Sandra Regina</creatorcontrib><title>Factors associated with specific clinical forms of oral candidiasis in HIV-infected Brazilian adults</title><title>Archives of oral biology</title><addtitle>Arch Oral Biol</addtitle><description>Abstract Objective This study assesses the association among factors related with specific clinical forms of oral candidiasis (OC) in HIV-infected Brazilian adults. Design This study was conducted with 590 HIV-infected adults from 1997 to 2004. The OC diagnosis was based in accordance with the EC-Clearinghouse classification. Multivariate logistic regression analyses were performed to measure the association between HAART and OC, with pseudomembranous [PC], erythematous [EC], and angular cheilitis [AC]) adjusted for HIV-related diseases, smoking, alcohol consumption, injecting and non-injecting drug use. Results Two hundred and eighteen (37.0%) individuals were undergoing HAART. The prevalence of PC, EC and AC was 21.2%, 15.7% and 8.8%, respectively. Approximately 64% of the individuals with PC and EC, and 76.5% with AC had absolute CD4 levels ≤200 cells/mm3 . The results of the multivariate analysis showed that subjects not undergoing HAART had a significantly higher odds ratio for PC [OR 3.67 (95% CI: 1.97–6.80)] and EC [OR 1.88 (95% CI: 1.04–3.39)], and AC [OR 4.56 (95% CI: 1.58–13.19)]. In addition, smoking [OR 2.58 (95% CI: 1.43–4.68)] and pneumocystis pneumonia [OR 1.92 (95% CI: 1.07–3.42)] were associated with PC, while high alcohol consumption [OR 3.40 (95% CI: 1.13–10.18)] and cytomegalovirus infection [OR 2.34 (95% CI: 1.06–5.15)] were associated with EC. Conclusion The data indicates that the odds of having all clinical forms of OC are higher in HIV-infected adults not receiving HAART.</description><subject>Adult</subject><subject>Advanced Basic Science</subject><subject>AIDS-Related Opportunistic Infections - diagnosis</subject><subject>Alcohol Drinking</subject><subject>Antiretroviral Therapy, Highly Active</subject><subject>Brazil</subject><subject>Candidiasis, Oral - diagnosis</subject><subject>CD4 Lymphocyte Count</subject><subject>Cheilitis - diagnosis</subject><subject>Cross-Sectional Studies</subject><subject>Cytomegalovirus Infections - diagnosis</subject><subject>Dentistry</subject><subject>Educational Status</subject><subject>Female</subject><subject>Highly active antiretroviral therapy</subject><subject>HIV infection</subject><subject>HIV Infections - complications</subject><subject>HIV Infections - drug therapy</subject><subject>Humans</subject><subject>Income</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Oral candidiasis</subject><subject>Pneumonia, Pneumocystis - diagnosis</subject><subject>Sarcoma, Kaposi - diagnosis</subject><subject>Smoking</subject><subject>Substance Abuse, Intravenous - complications</subject><subject>Substance-Related Disorders - complications</subject><subject>Toxoplasmosis - diagnosis</subject><subject>Tuberculosis - diagnosis</subject><subject>Young Adult</subject><issn>0003-9969</issn><issn>1879-1506</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU1v1DAQhi0EokvhLyBz45LFdhzv5oIEK0orVeLAx9VyxhN1lmy8eJKi8utxtC1CnDhY_nrnfTXPCPFKq7VW2r3Zr0OGm5TD0FFaG6VNeV8rtXkkVnq7aSvdKPdYrJRSddW2rj0Tz5j35do4p5-KM1NrUyu3XYl4EWBKmWVgTkBhwih_0nQj-YhAPYGEgUaCMMg-5QPL1MslWEIYI0UKTCxplJdX3yoae4TF4H0Ov2igMMoQ52Hi5-JJHwbGF_f7ufh68eHL7rK6_vTxavfuugJbm6nSprW6wxBdHdsW0AUAwK5xBrE3tnSmYtTW2laDsxZsDA46u7W6ibrusD4Xr0--x5x-zMiTPxADDkMYMc3sdb1RrjbFsEjbkxRyYs7Y-2OmQ8h3Xiu_QPZ7_xdkv0BevgrkUvvyPmbuDhj_VD5QLYLdSYCl2VvC7BkIR8BIuRDyMdF_xbz9x-VhFN_xDnmf5jwWml57Nl75z8u0l2FrUw5NWb8BkKCpoQ</recordid><startdate>20130601</startdate><enddate>20130601</enddate><creator>Gonçalves, Lucio Souza</creator><creator>Silva, Arley</creator><creator>Ferreira, Sônia Maria Soares</creator><creator>Sousa, Celso Oliveira</creator><creator>Fontes, Tatiana Vasconcellos</creator><creator>Vettore, Mario Vianna</creator><creator>Torres, Sandra Regina</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20130601</creationdate><title>Factors associated with specific clinical forms of oral candidiasis in HIV-infected Brazilian adults</title><author>Gonçalves, Lucio Souza ; Silva, Arley ; Ferreira, Sônia Maria Soares ; Sousa, Celso Oliveira ; Fontes, Tatiana Vasconcellos ; Vettore, Mario Vianna ; Torres, Sandra Regina</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c432t-12941bead63d99ce6accceb562eef241870dd144491c644c4da6cb48415d13be3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Advanced Basic Science</topic><topic>AIDS-Related Opportunistic Infections - diagnosis</topic><topic>Alcohol Drinking</topic><topic>Antiretroviral Therapy, Highly Active</topic><topic>Brazil</topic><topic>Candidiasis, Oral - diagnosis</topic><topic>CD4 Lymphocyte Count</topic><topic>Cheilitis - diagnosis</topic><topic>Cross-Sectional Studies</topic><topic>Cytomegalovirus Infections - diagnosis</topic><topic>Dentistry</topic><topic>Educational Status</topic><topic>Female</topic><topic>Highly active antiretroviral therapy</topic><topic>HIV infection</topic><topic>HIV Infections - complications</topic><topic>HIV Infections - drug therapy</topic><topic>Humans</topic><topic>Income</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Oral candidiasis</topic><topic>Pneumonia, Pneumocystis - diagnosis</topic><topic>Sarcoma, Kaposi - diagnosis</topic><topic>Smoking</topic><topic>Substance Abuse, Intravenous - complications</topic><topic>Substance-Related Disorders - complications</topic><topic>Toxoplasmosis - diagnosis</topic><topic>Tuberculosis - diagnosis</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gonçalves, Lucio Souza</creatorcontrib><creatorcontrib>Silva, Arley</creatorcontrib><creatorcontrib>Ferreira, Sônia Maria Soares</creatorcontrib><creatorcontrib>Sousa, Celso Oliveira</creatorcontrib><creatorcontrib>Fontes, Tatiana Vasconcellos</creatorcontrib><creatorcontrib>Vettore, Mario Vianna</creatorcontrib><creatorcontrib>Torres, Sandra Regina</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of oral biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gonçalves, Lucio Souza</au><au>Silva, Arley</au><au>Ferreira, Sônia Maria Soares</au><au>Sousa, Celso Oliveira</au><au>Fontes, Tatiana Vasconcellos</au><au>Vettore, Mario Vianna</au><au>Torres, Sandra Regina</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Factors associated with specific clinical forms of oral candidiasis in HIV-infected Brazilian adults</atitle><jtitle>Archives of oral biology</jtitle><addtitle>Arch Oral Biol</addtitle><date>2013-06-01</date><risdate>2013</risdate><volume>58</volume><issue>6</issue><spage>657</spage><epage>663</epage><pages>657-663</pages><issn>0003-9969</issn><eissn>1879-1506</eissn><abstract>Abstract Objective This study assesses the association among factors related with specific clinical forms of oral candidiasis (OC) in HIV-infected Brazilian adults. Design This study was conducted with 590 HIV-infected adults from 1997 to 2004. The OC diagnosis was based in accordance with the EC-Clearinghouse classification. Multivariate logistic regression analyses were performed to measure the association between HAART and OC, with pseudomembranous [PC], erythematous [EC], and angular cheilitis [AC]) adjusted for HIV-related diseases, smoking, alcohol consumption, injecting and non-injecting drug use. Results Two hundred and eighteen (37.0%) individuals were undergoing HAART. The prevalence of PC, EC and AC was 21.2%, 15.7% and 8.8%, respectively. Approximately 64% of the individuals with PC and EC, and 76.5% with AC had absolute CD4 levels ≤200 cells/mm3 . The results of the multivariate analysis showed that subjects not undergoing HAART had a significantly higher odds ratio for PC [OR 3.67 (95% CI: 1.97–6.80)] and EC [OR 1.88 (95% CI: 1.04–3.39)], and AC [OR 4.56 (95% CI: 1.58–13.19)]. In addition, smoking [OR 2.58 (95% CI: 1.43–4.68)] and pneumocystis pneumonia [OR 1.92 (95% CI: 1.07–3.42)] were associated with PC, while high alcohol consumption [OR 3.40 (95% CI: 1.13–10.18)] and cytomegalovirus infection [OR 2.34 (95% CI: 1.06–5.15)] were associated with EC. Conclusion The data indicates that the odds of having all clinical forms of OC are higher in HIV-infected adults not receiving HAART.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>23123068</pmid><doi>10.1016/j.archoralbio.2012.10.007</doi><tpages>7</tpages></addata></record> |
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subjects | Adult Advanced Basic Science AIDS-Related Opportunistic Infections - diagnosis Alcohol Drinking Antiretroviral Therapy, Highly Active Brazil Candidiasis, Oral - diagnosis CD4 Lymphocyte Count Cheilitis - diagnosis Cross-Sectional Studies Cytomegalovirus Infections - diagnosis Dentistry Educational Status Female Highly active antiretroviral therapy HIV infection HIV Infections - complications HIV Infections - drug therapy Humans Income Male Middle Aged Oral candidiasis Pneumonia, Pneumocystis - diagnosis Sarcoma, Kaposi - diagnosis Smoking Substance Abuse, Intravenous - complications Substance-Related Disorders - complications Toxoplasmosis - diagnosis Tuberculosis - diagnosis Young Adult |
title | Factors associated with specific clinical forms of oral candidiasis in HIV-infected Brazilian adults |
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