Chemical approach for interconversion of (S)- and (R)-α-amino acids
Here we report a general method for the preparation of unnatural (R)-α-amino acids via complexation of α-(phenyl)ethylamine derived chiral reagent (S)- with various (S)-α-amino acids. The reactions proceed with synthetically useful chemical yields and thermodynamically controlled diastereoselectivit...
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| Veröffentlicht in: | Organic & biomolecular chemistry 2013-07, Vol.11 (27), p.4503-4507 |
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| container_end_page | 4507 |
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| container_issue | 27 |
| container_start_page | 4503 |
| container_title | Organic & biomolecular chemistry |
| container_volume | 11 |
| creator | Sorochinsky, Alexander E Ueki, Hisanori Aceña, José Luis Ellis, Trevor K Moriwaki, Hiroki Sato, Tatsunori Soloshonok, Vadim A |
| description | Here we report a general method for the preparation of unnatural (R)-α-amino acids via complexation of α-(phenyl)ethylamine derived chiral reagent (S)- with various (S)-α-amino acids. The reactions proceed with synthetically useful chemical yields and thermodynamically controlled diastereoselectivity. Chiral reagent (S)- can be conveniently recovered and reused without any loss of enantiomeric purity and reactivity. |
| doi_str_mv | 10.1039/c3ob40541a |
| format | Article |
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| fulltext | fulltext |
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| ispartof | Organic & biomolecular chemistry, 2013-07, Vol.11 (27), p.4503-4507 |
| issn | 1477-0520 1477-0539 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1370125221 |
| source | MEDLINE; Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Amino Acids - chemical synthesis Amino Acids - chemistry Indicators and Reagents Phenethylamines - chemistry Stereoisomerism |
| title | Chemical approach for interconversion of (S)- and (R)-α-amino acids |
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