Inhibition of Ca2+/Calmodulin–Dependent Protein Kinase Kinase 2 Stimulates Osteoblast Formation and Inhibits Osteoclast Differentiation

ABSTRACT Bone remodeling, a physiological process characterized by bone formation by osteoblasts (OBs) and resorption of preexisting bone matrix by osteoclasts (OCs), is vital for the maintenance of healthy bone tissue in adult humans. Imbalances in this vital process result in pathological conditio...

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Veröffentlicht in:	Journal of bone and mineral research 2013-07, Vol.28 (7), p.1599-1610
Hauptverfasser:	Cary, Rachel L, Waddell, Seid, Racioppi, Luigi, Long, Fanxin, Novack, Deborah V, Voor, Michael J, Sankar, Uma
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Animals Benzimidazoles - pharmacology Bone marrow Bone Marrow Cells - enzymology Bone Remodeling - drug effects Bone Remodeling - physiology CA2+/CALMODULIN (CAM)‐DEPENDENT PROTEIN KINASE KINASE 2 Calcium-Calmodulin-Dependent Protein Kinase Kinase - antagonists & inhibitors Calcium-Calmodulin-Dependent Protein Kinase Kinase - genetics Calcium-Calmodulin-Dependent Protein Kinase Kinase - metabolism Cell Differentiation - drug effects Cell Differentiation - physiology CREB-Binding Protein - genetics CREB-Binding Protein - metabolism Cyclic AMP-Dependent Protein Kinases - genetics Cyclic AMP-Dependent Protein Kinases - metabolism Female Humans Kinases Mesenchymal Stem Cells - enzymology Mice Mice, Knockout Naphthalimides - pharmacology NFATC Transcription Factors - genetics NFATC Transcription Factors - metabolism OSTEOBLASTS Osteoblasts - cytology Osteoblasts - enzymology OSTEOCLASTS Osteoclasts - cytology Osteoclasts - enzymology Osteoporosis - drug therapy Osteoporosis - enzymology Osteoporosis - genetics Ovariectomy PROTEIN KINASE A Proteins STO‐609
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