Opioid-sparing effect of ketamine during tonsillectomy in children
In the adult population, Ketamine is currently used as an antihyperalgesic and opioid-sparing agent during the perioperative period. However, for doses of ketamine up to 0.5mg/kg, these effects have not been found in pediatric population. The aim of the present study was to evaluate the efficacy of...
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| Veröffentlicht in: | Annales françaises d'anesthésie et de réanimation 2013-06, Vol.32 (6), p.387-391 |
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| container_title | Annales françaises d'anesthésie et de réanimation |
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| creator | Abback, P-S Ben Sallah, T Hilly, J Skhiri, A Silins, V Brasher, C François, M Van Den Abeele, T Wood, C Nivoche, Y Dahmani, S |
| description | In the adult population, Ketamine is currently used as an antihyperalgesic and opioid-sparing agent during the perioperative period. However, for doses of ketamine up to 0.5mg/kg, these effects have not been found in pediatric population. The aim of the present study was to evaluate the efficacy of a preoperative bolus of 1mg/kg of ketamine on postoperative pain intensity and morphine consumption in children undergoing tonsillectomy.
We have undertaken a retrospective comparison of 60 consecutive children operated for tonsillectomy in our institution before (first 30 patients) and after (last 30 patients) the introduction of a preoperative bolus of 1mg/kg of ketamine. Data collected were: age, ASA score, dose of intraoperative sufentanil, OPS score during PACU stay and the first postoperative day, morphine consumption during PACU stay and the first postoperative day, psychodysleptic manifestations, pain at first solid oral intake and postoperative respiratory complications or haemorrhage.
No difference was found between the two groups in terms of demographic characteristics. Perioperative doses of sufentanil, postoperative opioid consumption or pain score in PACU or during 24hours were similar between the two groups. The two groups did not differ in terms of pain at first oral intake, or other adverse effects.
These results suggest that 1mg/kg of ketamine administered right after anaesthesia induction in children undergoing tonsillectomy did not result in an opioid sparing effect. |
| doi_str_mv | 10.1016/j.annfar.2013.02.026 |
| format | Article |
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We have undertaken a retrospective comparison of 60 consecutive children operated for tonsillectomy in our institution before (first 30 patients) and after (last 30 patients) the introduction of a preoperative bolus of 1mg/kg of ketamine. Data collected were: age, ASA score, dose of intraoperative sufentanil, OPS score during PACU stay and the first postoperative day, morphine consumption during PACU stay and the first postoperative day, psychodysleptic manifestations, pain at first solid oral intake and postoperative respiratory complications or haemorrhage.
No difference was found between the two groups in terms of demographic characteristics. Perioperative doses of sufentanil, postoperative opioid consumption or pain score in PACU or during 24hours were similar between the two groups. The two groups did not differ in terms of pain at first oral intake, or other adverse effects.
These results suggest that 1mg/kg of ketamine administered right after anaesthesia induction in children undergoing tonsillectomy did not result in an opioid sparing effect.</description><identifier>EISSN: 1769-6623</identifier><identifier>DOI: 10.1016/j.annfar.2013.02.026</identifier><identifier>PMID: 23623534</identifier><language>fre</language><publisher>France</publisher><subject>Adolescent ; Analgesics, Non-Narcotic - administration & dosage ; Analgesics, Non-Narcotic - adverse effects ; Analgesics, Non-Narcotic - therapeutic use ; Anesthetics, Dissociative - administration & dosage ; Anesthetics, Dissociative - adverse effects ; Child ; Child, Preschool ; Drug Evaluation ; Eating ; Female ; Hallucinations - chemically induced ; Humans ; Injections, Intravenous ; Ketamine - adverse effects ; Ketamine - therapeutic use ; Male ; Morphine - administration & dosage ; Morphine - therapeutic use ; Narcotics - administration & dosage ; Narcotics - therapeutic use ; Pain, Postoperative - drug therapy ; Pain, Postoperative - prevention & control ; Postoperative Nausea and Vomiting - etiology ; Premedication ; Recovery of Function ; Retrospective Studies ; Sufentanil - therapeutic use ; Tonsillectomy</subject><ispartof>Annales françaises d'anesthésie et de réanimation, 2013-06, Vol.32 (6), p.387-391</ispartof><rights>Copyright © 2013 Société française d’anesthésie et de réanimation (Sfar). Published by Elsevier SAS. All rights reserved.</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23623534$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Abback, P-S</creatorcontrib><creatorcontrib>Ben Sallah, T</creatorcontrib><creatorcontrib>Hilly, J</creatorcontrib><creatorcontrib>Skhiri, A</creatorcontrib><creatorcontrib>Silins, V</creatorcontrib><creatorcontrib>Brasher, C</creatorcontrib><creatorcontrib>François, M</creatorcontrib><creatorcontrib>Van Den Abeele, T</creatorcontrib><creatorcontrib>Wood, C</creatorcontrib><creatorcontrib>Nivoche, Y</creatorcontrib><creatorcontrib>Dahmani, S</creatorcontrib><title>Opioid-sparing effect of ketamine during tonsillectomy in children</title><title>Annales françaises d'anesthésie et de réanimation</title><addtitle>Ann Fr Anesth Reanim</addtitle><description>In the adult population, Ketamine is currently used as an antihyperalgesic and opioid-sparing agent during the perioperative period. However, for doses of ketamine up to 0.5mg/kg, these effects have not been found in pediatric population. The aim of the present study was to evaluate the efficacy of a preoperative bolus of 1mg/kg of ketamine on postoperative pain intensity and morphine consumption in children undergoing tonsillectomy.
We have undertaken a retrospective comparison of 60 consecutive children operated for tonsillectomy in our institution before (first 30 patients) and after (last 30 patients) the introduction of a preoperative bolus of 1mg/kg of ketamine. Data collected were: age, ASA score, dose of intraoperative sufentanil, OPS score during PACU stay and the first postoperative day, morphine consumption during PACU stay and the first postoperative day, psychodysleptic manifestations, pain at first solid oral intake and postoperative respiratory complications or haemorrhage.
No difference was found between the two groups in terms of demographic characteristics. Perioperative doses of sufentanil, postoperative opioid consumption or pain score in PACU or during 24hours were similar between the two groups. The two groups did not differ in terms of pain at first oral intake, or other adverse effects.
These results suggest that 1mg/kg of ketamine administered right after anaesthesia induction in children undergoing tonsillectomy did not result in an opioid sparing effect.</description><subject>Adolescent</subject><subject>Analgesics, Non-Narcotic - administration & dosage</subject><subject>Analgesics, Non-Narcotic - adverse effects</subject><subject>Analgesics, Non-Narcotic - therapeutic use</subject><subject>Anesthetics, Dissociative - administration & dosage</subject><subject>Anesthetics, Dissociative - adverse effects</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Drug Evaluation</subject><subject>Eating</subject><subject>Female</subject><subject>Hallucinations - chemically induced</subject><subject>Humans</subject><subject>Injections, Intravenous</subject><subject>Ketamine - adverse effects</subject><subject>Ketamine - therapeutic use</subject><subject>Male</subject><subject>Morphine - administration & dosage</subject><subject>Morphine - therapeutic use</subject><subject>Narcotics - administration & dosage</subject><subject>Narcotics - therapeutic use</subject><subject>Pain, Postoperative - drug therapy</subject><subject>Pain, Postoperative - prevention & control</subject><subject>Postoperative Nausea and Vomiting - etiology</subject><subject>Premedication</subject><subject>Recovery of Function</subject><subject>Retrospective Studies</subject><subject>Sufentanil - therapeutic use</subject><subject>Tonsillectomy</subject><issn>1769-6623</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1T8tOwzAQtJAQLYU_QChHLglrO7GbI1S8pEq9wDnyY11cEifEyaF_jwVF2tWMZkY7WkJuKBQUqLg_FCoEp8aCAeUFsDTijCypFHUuBOMLchnjAQAqXtILsmA8iYkvyeNu8L23eRzU6MM-Q-fQTFnvsi-cVOcDZnb-daY-RN-2ye27Y-ZDZj59a0cMV-TcqTbi9QlX5OP56X3zmm93L2-bh22-p0JOOWNV7ZxcpwLQKC2AFmioVdrIdYlYMtDgDFNCWy60rgUzAtJyyUurFF-Ru7-7w9h_zxinpvPRYNuqgP0cG8olUFZWVKbo7Sk66w5tM4y-U-Ox-f-b_wDni1sF</recordid><startdate>20130601</startdate><enddate>20130601</enddate><creator>Abback, P-S</creator><creator>Ben Sallah, T</creator><creator>Hilly, J</creator><creator>Skhiri, A</creator><creator>Silins, V</creator><creator>Brasher, C</creator><creator>François, M</creator><creator>Van Den Abeele, T</creator><creator>Wood, C</creator><creator>Nivoche, Y</creator><creator>Dahmani, S</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20130601</creationdate><title>Opioid-sparing effect of ketamine during tonsillectomy in children</title><author>Abback, P-S ; Ben Sallah, T ; Hilly, J ; Skhiri, A ; Silins, V ; Brasher, C ; François, M ; Van Den Abeele, T ; Wood, C ; Nivoche, Y ; Dahmani, S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g167t-2259ff78ffe0be7d00b6ec1dabc784ee420b0fc2a6bd36bb962c602c63734daa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>fre</language><creationdate>2013</creationdate><topic>Adolescent</topic><topic>Analgesics, Non-Narcotic - administration & dosage</topic><topic>Analgesics, Non-Narcotic - adverse effects</topic><topic>Analgesics, Non-Narcotic - therapeutic use</topic><topic>Anesthetics, Dissociative - administration & dosage</topic><topic>Anesthetics, Dissociative - adverse effects</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Drug Evaluation</topic><topic>Eating</topic><topic>Female</topic><topic>Hallucinations - chemically induced</topic><topic>Humans</topic><topic>Injections, Intravenous</topic><topic>Ketamine - adverse effects</topic><topic>Ketamine - therapeutic use</topic><topic>Male</topic><topic>Morphine - administration & dosage</topic><topic>Morphine - therapeutic use</topic><topic>Narcotics - administration & dosage</topic><topic>Narcotics - therapeutic use</topic><topic>Pain, Postoperative - drug therapy</topic><topic>Pain, Postoperative - prevention & control</topic><topic>Postoperative Nausea and Vomiting - etiology</topic><topic>Premedication</topic><topic>Recovery of Function</topic><topic>Retrospective Studies</topic><topic>Sufentanil - therapeutic use</topic><topic>Tonsillectomy</topic><toplevel>online_resources</toplevel><creatorcontrib>Abback, P-S</creatorcontrib><creatorcontrib>Ben Sallah, T</creatorcontrib><creatorcontrib>Hilly, J</creatorcontrib><creatorcontrib>Skhiri, A</creatorcontrib><creatorcontrib>Silins, V</creatorcontrib><creatorcontrib>Brasher, C</creatorcontrib><creatorcontrib>François, M</creatorcontrib><creatorcontrib>Van Den Abeele, T</creatorcontrib><creatorcontrib>Wood, C</creatorcontrib><creatorcontrib>Nivoche, Y</creatorcontrib><creatorcontrib>Dahmani, S</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Annales françaises d'anesthésie et de réanimation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Abback, P-S</au><au>Ben Sallah, T</au><au>Hilly, J</au><au>Skhiri, A</au><au>Silins, V</au><au>Brasher, C</au><au>François, M</au><au>Van Den Abeele, T</au><au>Wood, C</au><au>Nivoche, Y</au><au>Dahmani, S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Opioid-sparing effect of ketamine during tonsillectomy in children</atitle><jtitle>Annales françaises d'anesthésie et de réanimation</jtitle><addtitle>Ann Fr Anesth Reanim</addtitle><date>2013-06-01</date><risdate>2013</risdate><volume>32</volume><issue>6</issue><spage>387</spage><epage>391</epage><pages>387-391</pages><eissn>1769-6623</eissn><abstract>In the adult population, Ketamine is currently used as an antihyperalgesic and opioid-sparing agent during the perioperative period. However, for doses of ketamine up to 0.5mg/kg, these effects have not been found in pediatric population. The aim of the present study was to evaluate the efficacy of a preoperative bolus of 1mg/kg of ketamine on postoperative pain intensity and morphine consumption in children undergoing tonsillectomy.
We have undertaken a retrospective comparison of 60 consecutive children operated for tonsillectomy in our institution before (first 30 patients) and after (last 30 patients) the introduction of a preoperative bolus of 1mg/kg of ketamine. Data collected were: age, ASA score, dose of intraoperative sufentanil, OPS score during PACU stay and the first postoperative day, morphine consumption during PACU stay and the first postoperative day, psychodysleptic manifestations, pain at first solid oral intake and postoperative respiratory complications or haemorrhage.
No difference was found between the two groups in terms of demographic characteristics. Perioperative doses of sufentanil, postoperative opioid consumption or pain score in PACU or during 24hours were similar between the two groups. The two groups did not differ in terms of pain at first oral intake, or other adverse effects.
These results suggest that 1mg/kg of ketamine administered right after anaesthesia induction in children undergoing tonsillectomy did not result in an opioid sparing effect.</abstract><cop>France</cop><pmid>23623534</pmid><doi>10.1016/j.annfar.2013.02.026</doi><tpages>5</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adolescent Analgesics, Non-Narcotic - administration & dosage Analgesics, Non-Narcotic - adverse effects Analgesics, Non-Narcotic - therapeutic use Anesthetics, Dissociative - administration & dosage Anesthetics, Dissociative - adverse effects Child Child, Preschool Drug Evaluation Eating Female Hallucinations - chemically induced Humans Injections, Intravenous Ketamine - adverse effects Ketamine - therapeutic use Male Morphine - administration & dosage Morphine - therapeutic use Narcotics - administration & dosage Narcotics - therapeutic use Pain, Postoperative - drug therapy Pain, Postoperative - prevention & control Postoperative Nausea and Vomiting - etiology Premedication Recovery of Function Retrospective Studies Sufentanil - therapeutic use Tonsillectomy |
| title | Opioid-sparing effect of ketamine during tonsillectomy in children |
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