Polyethylene Glycol Modified FGF21 Engineered to Maximize Potency and Minimize Vacuole Formation

Fibroblast growth factor 21 (FGF21) is involved in regulating energy metabolism, and it has shown significant promise as a treatment for type II diabetes; however, the native protein has a very short circulating half-life necessitating frequent injections to maintain a physiological effect. Polyethy...

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Veröffentlicht in:	Bioconjugate chemistry 2013-06, Vol.24 (6), p.915-925
Hauptverfasser:	Xu, Jing, Bussiere, Jeanine, Yie, Junming, Sickmier, Allen, An, Phil, Belouski, Ed, Stanislaus, Shanaka, Walker, Kenneth W
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Fibroblast Growth Factors - chemistry Fibroblast Growth Factors - metabolism HEK293 Cells Humans Male Metabolism Mice Mice, Obese Models, Molecular Polyethylene glycol Polyethylene Glycols - chemistry Polyethylene Glycols - metabolism Protein Engineering Proteins Risk assessment Vacuoles - genetics Vacuoles - metabolism
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