The Complexity of Arterial Classical Monocyte Recruitment
Accumulation of classical monocytes is imperative for the progression of atherosclerosis. Hence, therapeutic interference with mechanisms of lesional monocyte recruitment, the primary mechanism controlling macrophage accumulation, may allow for targeting atheroprogression and its clinical complicati...
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| Veröffentlicht in: | Journal of innate immunity 2013-01, Vol.5 (4), p.358-366 |
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| container_title | Journal of innate immunity |
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| creator | Drechsler, Maik Soehnlein, Oliver |
| description | Accumulation of classical monocytes is imperative for the progression of atherosclerosis. Hence, therapeutic interference with mechanisms of lesional monocyte recruitment, the primary mechanism controlling macrophage accumulation, may allow for targeting atheroprogression and its clinical complications. Here, we review the important role of classical monocytes in atheroprogression as well as their routes of arterial recruitment. We specifically highlight the role of cell adhesion molecules as well as of platelet-derived chemokines and neutrophil-borne alarmins. |
| doi_str_mv | 10.1159/000348795 |
| format | Article |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Animals Arteries - immunology Atherosclerosis - immunology Blood Platelets - immunology Cell Adhesion Molecules - immunology Cell Movement - immunology Chemokines - immunology Disease Progression Humans Macrophages - immunology Molecular Targeted Therapy Neutrophils - immunology Review |
| title | The Complexity of Arterial Classical Monocyte Recruitment |
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