Biofortified cassava increases β-carotene and vitamin A concentrations in the TAG-rich plasma layer of American women
Biofortification of cassava with the provitamin A carotenoid β-carotene is a potential mechanism for alleviating vitamin A deficiency. Cassava is a staple food in the African diet, but data regarding the human bioavailability of β-carotene from this food are scarce. The objective of the present stud...
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| Veröffentlicht in: | British journal of nutrition 2013-07, Vol.110 (2), p.310-320 |
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| creator | La Frano, Michael R. Woodhouse, Leslie R. Burnett, Dustin J. Burri, Betty J. |
| description | Biofortification of cassava with the provitamin A carotenoid β-carotene is a potential mechanism for alleviating vitamin A deficiency. Cassava is a staple food in the African diet, but data regarding the human bioavailability of β-carotene from this food are scarce. The objective of the present study was to evaluate provitamin A-enhanced cassava as a source of β-carotene and vitamin A for healthy adult women. The study was a randomised, cross-over trial of ten American women. The subjects consumed three different porridges separated by 2 week washout periods. Treatment meals (containing 100 g cassava) included: biofortified cassava (2 mg β-carotene) porridge with added oil (15 ml peanut or rapeseed oil, 20 g total fat); biofortified cassava porridge without added oil (6 g total fat); unfortified white cassava porridge with a 0·3 mg retinyl palmitate reference dose and added oil (20 g total fat). Blood was collected six times from − 0·5 to 9·5 h post-feeding. TAG-rich lipoprotein (TRL) plasma was separated by ultracentrifugation and analysed using HPLC with coulometric array electrochemical detection. The AUC for retinyl palmitate increased after the biofortified cassava meals were fed (P |
| doi_str_mv | 10.1017/S0007114512005004 |
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Cassava is a staple food in the African diet, but data regarding the human bioavailability of β-carotene from this food are scarce. The objective of the present study was to evaluate provitamin A-enhanced cassava as a source of β-carotene and vitamin A for healthy adult women. The study was a randomised, cross-over trial of ten American women. The subjects consumed three different porridges separated by 2 week washout periods. Treatment meals (containing 100 g cassava) included: biofortified cassava (2 mg β-carotene) porridge with added oil (15 ml peanut or rapeseed oil, 20 g total fat); biofortified cassava porridge without added oil (6 g total fat); unfortified white cassava porridge with a 0·3 mg retinyl palmitate reference dose and added oil (20 g total fat). Blood was collected six times from − 0·5 to 9·5 h post-feeding. TAG-rich lipoprotein (TRL) plasma was separated by ultracentrifugation and analysed using HPLC with coulometric array electrochemical detection. The AUC for retinyl palmitate increased after the biofortified cassava meals were fed (P< 0·05). Vitamin A conversion was 4·2 (sd 3·1) and 4·5 (sd 3·1) μg β-carotene:1 μg retinol, with and without added oil, respectively. These results show that biofortified cassava increases β-carotene and retinyl palmitate TRL plasma concentrations in healthy well-nourished adult women, suggesting that it is a viable intervention food for preventing vitamin A deficiency.</description><identifier>ISSN: 0007-1145</identifier><identifier>EISSN: 1475-2662</identifier><identifier>DOI: 10.1017/S0007114512005004</identifier><identifier>PMID: 23332040</identifier><identifier>CODEN: BJNUAV</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Adult ; Area Under Curve ; beta Carotene - pharmacology ; Biological and medical sciences ; Feeding. Feeding behavior ; Female ; Food, Fortified ; Fundamental and applied biological sciences. Psychology ; Human and Clinical Nutrition ; Humans ; Lipoproteins - blood ; Manihot - chemistry ; Plant Oils - pharmacology ; Reference Values ; Triglycerides - blood ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; Vitamin A - analogs & derivatives ; Vitamin A - blood ; Vitamin A Deficiency - blood ; Vitamin A Deficiency - diet therapy ; Young Adult</subject><ispartof>British journal of nutrition, 2013-07, Vol.110 (2), p.310-320</ispartof><rights>Copyright © The Authors 2013</rights><rights>2014 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c418t-43b9c2d091ef9d346427a544025b7870cc2376456d06bd1cf72453883ebbba523</citedby><cites>FETCH-LOGICAL-c418t-43b9c2d091ef9d346427a544025b7870cc2376456d06bd1cf72453883ebbba523</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S0007114512005004/type/journal_article$$EHTML$$P50$$Gcambridge$$H</linktohtml><link.rule.ids>164,314,776,780,27903,27904,55606</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27468842$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23332040$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>La Frano, Michael R.</creatorcontrib><creatorcontrib>Woodhouse, Leslie R.</creatorcontrib><creatorcontrib>Burnett, Dustin J.</creatorcontrib><creatorcontrib>Burri, Betty J.</creatorcontrib><title>Biofortified cassava increases β-carotene and vitamin A concentrations in the TAG-rich plasma layer of American women</title><title>British journal of nutrition</title><addtitle>Br J Nutr</addtitle><description>Biofortification of cassava with the provitamin A carotenoid β-carotene is a potential mechanism for alleviating vitamin A deficiency. Cassava is a staple food in the African diet, but data regarding the human bioavailability of β-carotene from this food are scarce. The objective of the present study was to evaluate provitamin A-enhanced cassava as a source of β-carotene and vitamin A for healthy adult women. The study was a randomised, cross-over trial of ten American women. The subjects consumed three different porridges separated by 2 week washout periods. Treatment meals (containing 100 g cassava) included: biofortified cassava (2 mg β-carotene) porridge with added oil (15 ml peanut or rapeseed oil, 20 g total fat); biofortified cassava porridge without added oil (6 g total fat); unfortified white cassava porridge with a 0·3 mg retinyl palmitate reference dose and added oil (20 g total fat). Blood was collected six times from − 0·5 to 9·5 h post-feeding. TAG-rich lipoprotein (TRL) plasma was separated by ultracentrifugation and analysed using HPLC with coulometric array electrochemical detection. The AUC for retinyl palmitate increased after the biofortified cassava meals were fed (P< 0·05). Vitamin A conversion was 4·2 (sd 3·1) and 4·5 (sd 3·1) μg β-carotene:1 μg retinol, with and without added oil, respectively. These results show that biofortified cassava increases β-carotene and retinyl palmitate TRL plasma concentrations in healthy well-nourished adult women, suggesting that it is a viable intervention food for preventing vitamin A deficiency.</description><subject>Adult</subject><subject>Area Under Curve</subject><subject>beta Carotene - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Feeding. Feeding behavior</subject><subject>Female</subject><subject>Food, Fortified</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Human and Clinical Nutrition</subject><subject>Humans</subject><subject>Lipoproteins - blood</subject><subject>Manihot - chemistry</subject><subject>Plant Oils - pharmacology</subject><subject>Reference Values</subject><subject>Triglycerides - blood</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>Vitamin A - analogs & derivatives</subject><subject>Vitamin A - blood</subject><subject>Vitamin A Deficiency - blood</subject><subject>Vitamin A Deficiency - diet therapy</subject><subject>Young Adult</subject><issn>0007-1145</issn><issn>1475-2662</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtO5DAQRS3ECJrHB7BB3iDNJjPlR-Jk2SBeEtIsgHVUcSpglNiNnW7Eb82H8E2TFg0skGZVqqpz65YuY0cCfgkQ5vctABghdC4kQA6gt9hMaJNnsijkNput19l6v8v2Unqa2lJAtcN2pVJKgoYZW5260IU4us5Ryy2mhCvkzttImCjxt7-ZxRhG8sTRt3zlRhyc53Nug7fkx4ijCz5NEj4-Er-bX2bR2Ue-6DENyHt8pchDx-cDTXP0_CUM5A_Yjw77RIebus_uL87vzq6ymz-X12fzm8xqUY6ZVk1lZQuVoK5qlS60NJhrDTJvTGnAWqlMofOihaJphe2M1LkqS0VN02Au1T77-X53EcPzktJYDy5Z6nv0FJapFqqojDBlVU2oeEdtDClF6upFdAPG11pAvY67_hb3pDnenF82A7Wfio98J-BkA2Cy2HcRvXXpizO6KEu9_lNtzHFoomsfqH4Ky-inbP5j_w-FsZav</recordid><startdate>20130728</startdate><enddate>20130728</enddate><creator>La Frano, Michael R.</creator><creator>Woodhouse, Leslie R.</creator><creator>Burnett, Dustin J.</creator><creator>Burri, Betty J.</creator><general>Cambridge University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20130728</creationdate><title>Biofortified cassava increases β-carotene and vitamin A concentrations in the TAG-rich plasma layer of American women</title><author>La Frano, Michael R. ; Woodhouse, Leslie R. ; Burnett, Dustin J. ; Burri, Betty J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c418t-43b9c2d091ef9d346427a544025b7870cc2376456d06bd1cf72453883ebbba523</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Area Under Curve</topic><topic>beta Carotene - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Feeding. Feeding behavior</topic><topic>Female</topic><topic>Food, Fortified</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Human and Clinical Nutrition</topic><topic>Humans</topic><topic>Lipoproteins - blood</topic><topic>Manihot - chemistry</topic><topic>Plant Oils - pharmacology</topic><topic>Reference Values</topic><topic>Triglycerides - blood</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>Vitamin A - analogs & derivatives</topic><topic>Vitamin A - blood</topic><topic>Vitamin A Deficiency - blood</topic><topic>Vitamin A Deficiency - diet therapy</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>La Frano, Michael R.</creatorcontrib><creatorcontrib>Woodhouse, Leslie R.</creatorcontrib><creatorcontrib>Burnett, Dustin J.</creatorcontrib><creatorcontrib>Burri, Betty J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>La Frano, Michael R.</au><au>Woodhouse, Leslie R.</au><au>Burnett, Dustin J.</au><au>Burri, Betty J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Biofortified cassava increases β-carotene and vitamin A concentrations in the TAG-rich plasma layer of American women</atitle><jtitle>British journal of nutrition</jtitle><addtitle>Br J Nutr</addtitle><date>2013-07-28</date><risdate>2013</risdate><volume>110</volume><issue>2</issue><spage>310</spage><epage>320</epage><pages>310-320</pages><issn>0007-1145</issn><eissn>1475-2662</eissn><coden>BJNUAV</coden><abstract>Biofortification of cassava with the provitamin A carotenoid β-carotene is a potential mechanism for alleviating vitamin A deficiency. Cassava is a staple food in the African diet, but data regarding the human bioavailability of β-carotene from this food are scarce. The objective of the present study was to evaluate provitamin A-enhanced cassava as a source of β-carotene and vitamin A for healthy adult women. The study was a randomised, cross-over trial of ten American women. The subjects consumed three different porridges separated by 2 week washout periods. Treatment meals (containing 100 g cassava) included: biofortified cassava (2 mg β-carotene) porridge with added oil (15 ml peanut or rapeseed oil, 20 g total fat); biofortified cassava porridge without added oil (6 g total fat); unfortified white cassava porridge with a 0·3 mg retinyl palmitate reference dose and added oil (20 g total fat). Blood was collected six times from − 0·5 to 9·5 h post-feeding. TAG-rich lipoprotein (TRL) plasma was separated by ultracentrifugation and analysed using HPLC with coulometric array electrochemical detection. The AUC for retinyl palmitate increased after the biofortified cassava meals were fed (P< 0·05). Vitamin A conversion was 4·2 (sd 3·1) and 4·5 (sd 3·1) μg β-carotene:1 μg retinol, with and without added oil, respectively. These results show that biofortified cassava increases β-carotene and retinyl palmitate TRL plasma concentrations in healthy well-nourished adult women, suggesting that it is a viable intervention food for preventing vitamin A deficiency.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>23332040</pmid><doi>10.1017/S0007114512005004</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Area Under Curve beta Carotene - pharmacology Biological and medical sciences Feeding. Feeding behavior Female Food, Fortified Fundamental and applied biological sciences. Psychology Human and Clinical Nutrition Humans Lipoproteins - blood Manihot - chemistry Plant Oils - pharmacology Reference Values Triglycerides - blood Vertebrates: anatomy and physiology, studies on body, several organs or systems Vitamin A - analogs & derivatives Vitamin A - blood Vitamin A Deficiency - blood Vitamin A Deficiency - diet therapy Young Adult |
| title | Biofortified cassava increases β-carotene and vitamin A concentrations in the TAG-rich plasma layer of American women |
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