Phase I trial of the combination of the Akt inhibitor nelfinavir and chemoradiation for locally advanced rectal cancer

Abstract Purpose To investigate the toxicity of nelfinavir, administered during preoperative chemoradiotherapy (CRT) in patients with locally advanced rectal cancer. Material and methods Twelve patients were treated with chemoradiotherapy to 50.4 Gy combined with capecitabine 825 mg/m2 BID. Three do...

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Veröffentlicht in:	Radiotherapy and oncology 2013-05, Vol.107 (2), p.184-188
Hauptverfasser:	Buijsen, Jeroen, Lammering, Guido, Jansen, Rob L.H, Beets, Geerard L, Wals, Jaap, Sosef, Meindert, Den Boer, Marien O, Leijtens, Jeroen, Riedl, Robert G, Theys, Jan, Lambin, Philippe
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Chemoradiation Chemoradiotherapy Combined Modality Therapy Dose-Response Relationship, Drug Female Hematology, Oncology and Palliative Medicine Humans Male Middle Aged Nelfinavir Nelfinavir - adverse effects Nelfinavir - blood Nelfinavir - therapeutic use Phase I Proto-Oncogene Proteins c-akt - antagonists & inhibitors Rectal cancer Rectal Neoplasms - therapy
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