Fibroblast growth factor 21 protects against cardiac hypertrophy in mice

Fibroblast growth factor 21 is an endocrine factor, secreted mainly by the liver, that exerts metabolic actions that favour glucose metabolism. Its role in the heart is unknown. Here we show that Fgf21 −/− mice exhibit an increased relative heart weight and develop enhanced signs of dilatation and c...

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Veröffentlicht in:	Nature communications 2013-06, Vol.4 (1), p.2019-2019, Article 2019
Hauptverfasser:	Planavila, A., Redondo, I., Hondares, E., Vinciguerra, M., Munts, C., Iglesias, R., Gabrielli, L. A., Sitges, M., Giralt, M., van Bilsen, M., Villarroya, F.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/443/592/1540 631/45/612 692/308 Animals Animals, Newborn Body fat Cardiomegaly - diagnostic imaging Cardiomegaly - metabolism Cardiomegaly - pathology Cardiomegaly - prevention & control Cardiomyocytes Cardiotonic Agents - metabolism Fetus - metabolism Fibroblast Growth Factors - blood Fibroblast Growth Factors - deficiency Fibroblast Growth Factors - metabolism Fibroblasts Gene Expression Regulation Glucose Growth factors Heart failure Humanities and Social Sciences Inflammation - pathology Inflammation Mediators - metabolism Isoproterenol Liver Metabolism Mice multidisciplinary Myocardium - metabolism Myocardium - pathology Myocytes, Cardiac - metabolism Myocytes, Cardiac - pathology Phenylephrine Proteins Rats RNA, Messenger - genetics RNA, Messenger - metabolism Science Science (multidisciplinary) Ultrasonography
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