Myosin Vb controls biogenesis of post-Golgi Rab10 carriers during axon development
Polarized membrane addition is crucial for axon development and elongation during neuronal morphogenesis. This process is believed to be regulated by directed membrane trafficking of Rab10-containing post-Golgi carriers. However, the mechanisms underlying the biogenesis of these carriers remain uncl...
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| Veröffentlicht in: | Nature communications 2013-06, Vol.4 (1), p.2005-2005, Article 2005 |
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| creator | Liu, Yang Xu, Xiao-Hui Chen, Qi Wang, Tong Deng, Cai-Yun Song, Bao-Liang Du, Jiu-Lin Luo, Zhen-Ge |
| description | Polarized membrane addition is crucial for axon development and elongation during neuronal morphogenesis. This process is believed to be regulated by directed membrane trafficking of Rab10-containing post-Golgi carriers. However, the mechanisms underlying the biogenesis of these carriers remain unclear. Here, we report that Rab10 interaction with myosin Vb (MYO5B) determines the formation of Rab10 carriers and is important for axon development. Rab10 interacts with the exon D-encoded domain of MYO5B. Downregulating the expression of MYO5B (+D) or blocking its interaction with Rab10 impairs the fission of Rab10 vesicles from trans-Golgi membranes, causes a decrease in the number of Rab10 transport carriers and inhibits axon development in cultured hippocampal neurons. Furthermore, the MYO5B–Rab10 system is required for axon development of vertebrate neocortical neurons or zebrafish retinal ganglion cells
in vivo
. Thus, specific interaction between Rab10 and MYO5B controls the formation of Rab10 vesicles, which is required for axon development.
Polarized membrane addition during axon development requires post-Golgi Rab10 carriers, whose biogenesis mechanisms remain unknown. This work shows that specific interaction between Rab10 and MYO5B controls formation of the Rab10 carriers, and this process is essential for neuronal polarization. |
| doi_str_mv | 10.1038/ncomms3005 |
| format | Article |
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in vivo
. Thus, specific interaction between Rab10 and MYO5B controls the formation of Rab10 vesicles, which is required for axon development.
Polarized membrane addition during axon development requires post-Golgi Rab10 carriers, whose biogenesis mechanisms remain unknown. This work shows that specific interaction between Rab10 and MYO5B controls formation of the Rab10 carriers, and this process is essential for neuronal polarization.</description><identifier>ISSN: 2041-1723</identifier><identifier>EISSN: 2041-1723</identifier><identifier>DOI: 10.1038/ncomms3005</identifier><identifier>PMID: 23770993</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/378/2571 ; 631/80/313/1525 ; Amino Acid Sequence ; Animals ; Axons - drug effects ; Axons - metabolism ; Axons - ultrastructure ; Cell Polarity - drug effects ; Exons - genetics ; Fibroblasts - cytology ; Fibroblasts - drug effects ; Fibroblasts - metabolism ; Golgi Apparatus - drug effects ; Golgi Apparatus - metabolism ; Guanosine Triphosphate - metabolism ; HEK293 Cells ; Hippocampus - cytology ; Humanities and Social Sciences ; Humans ; Molecular Sequence Data ; Morpholinos - pharmacology ; multidisciplinary ; Myosins - chemistry ; Myosins - metabolism ; Optic Nerve - drug effects ; Optic Nerve - growth & development ; Optic Nerve - metabolism ; Protein Binding - drug effects ; rab GTP-Binding Proteins - metabolism ; Rats ; Retinal Ganglion Cells - cytology ; Retinal Ganglion Cells - drug effects ; Retinal Ganglion Cells - metabolism ; RNA, Small Interfering - metabolism ; Science ; Science (multidisciplinary) ; trans-Golgi Network - drug effects ; trans-Golgi Network - metabolism ; Transport Vesicles - drug effects ; Transport Vesicles - metabolism ; Transport Vesicles - ultrastructure ; Zebrafish ; Zebrafish Proteins - chemistry ; Zebrafish Proteins - metabolism</subject><ispartof>Nature communications, 2013-06, Vol.4 (1), p.2005-2005, Article 2005</ispartof><rights>Springer Nature Limited 2013</rights><rights>Copyright Nature Publishing Group Jun 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c453t-f3fc975d3efb92869b3767ef0b7f5067d7a23fe6e9eb83ed11017fa6b2660d393</citedby><cites>FETCH-LOGICAL-c453t-f3fc975d3efb92869b3767ef0b7f5067d7a23fe6e9eb83ed11017fa6b2660d393</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/ncomms3005$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://doi.org/10.1038/ncomms3005$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41096,42165,51551</link.rule.ids><linktorsrc>$$Uhttps://doi.org/10.1038/ncomms3005$$EView_record_in_Springer_Nature$$FView_record_in_$$GSpringer_Nature</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23770993$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Yang</creatorcontrib><creatorcontrib>Xu, Xiao-Hui</creatorcontrib><creatorcontrib>Chen, Qi</creatorcontrib><creatorcontrib>Wang, Tong</creatorcontrib><creatorcontrib>Deng, Cai-Yun</creatorcontrib><creatorcontrib>Song, Bao-Liang</creatorcontrib><creatorcontrib>Du, Jiu-Lin</creatorcontrib><creatorcontrib>Luo, Zhen-Ge</creatorcontrib><title>Myosin Vb controls biogenesis of post-Golgi Rab10 carriers during axon development</title><title>Nature communications</title><addtitle>Nat Commun</addtitle><addtitle>Nat Commun</addtitle><description>Polarized membrane addition is crucial for axon development and elongation during neuronal morphogenesis. This process is believed to be regulated by directed membrane trafficking of Rab10-containing post-Golgi carriers. However, the mechanisms underlying the biogenesis of these carriers remain unclear. Here, we report that Rab10 interaction with myosin Vb (MYO5B) determines the formation of Rab10 carriers and is important for axon development. Rab10 interacts with the exon D-encoded domain of MYO5B. Downregulating the expression of MYO5B (+D) or blocking its interaction with Rab10 impairs the fission of Rab10 vesicles from trans-Golgi membranes, causes a decrease in the number of Rab10 transport carriers and inhibits axon development in cultured hippocampal neurons. Furthermore, the MYO5B–Rab10 system is required for axon development of vertebrate neocortical neurons or zebrafish retinal ganglion cells
in vivo
. Thus, specific interaction between Rab10 and MYO5B controls the formation of Rab10 vesicles, which is required for axon development.
Polarized membrane addition during axon development requires post-Golgi Rab10 carriers, whose biogenesis mechanisms remain unknown. This work shows that specific interaction between Rab10 and MYO5B controls formation of the Rab10 carriers, and this process is essential for neuronal polarization.</description><subject>631/378/2571</subject><subject>631/80/313/1525</subject><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Axons - drug effects</subject><subject>Axons - metabolism</subject><subject>Axons - ultrastructure</subject><subject>Cell Polarity - drug effects</subject><subject>Exons - genetics</subject><subject>Fibroblasts - cytology</subject><subject>Fibroblasts - drug effects</subject><subject>Fibroblasts - metabolism</subject><subject>Golgi Apparatus - drug effects</subject><subject>Golgi Apparatus - metabolism</subject><subject>Guanosine Triphosphate - metabolism</subject><subject>HEK293 Cells</subject><subject>Hippocampus - cytology</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Molecular Sequence Data</subject><subject>Morpholinos - pharmacology</subject><subject>multidisciplinary</subject><subject>Myosins - chemistry</subject><subject>Myosins - metabolism</subject><subject>Optic Nerve - drug effects</subject><subject>Optic Nerve - growth & development</subject><subject>Optic Nerve - metabolism</subject><subject>Protein Binding - drug effects</subject><subject>rab GTP-Binding Proteins - metabolism</subject><subject>Rats</subject><subject>Retinal Ganglion Cells - cytology</subject><subject>Retinal Ganglion Cells - drug effects</subject><subject>Retinal Ganglion Cells - metabolism</subject><subject>RNA, Small Interfering - metabolism</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>trans-Golgi Network - drug effects</subject><subject>trans-Golgi Network - metabolism</subject><subject>Transport Vesicles - drug effects</subject><subject>Transport Vesicles - metabolism</subject><subject>Transport Vesicles - ultrastructure</subject><subject>Zebrafish</subject><subject>Zebrafish Proteins - chemistry</subject><subject>Zebrafish Proteins - metabolism</subject><issn>2041-1723</issn><issn>2041-1723</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpl0EFLwzAUB_AgihtzFz-ABLyIUk2aNmmOIjqFiTDUa2nal5HRJjVpRb-9HZs6NJeXw4__e_wROqbkkhKWXdnSNU1ghKR7aByThEZUxGx_5z9C0xBWZHhM0ixJDtEoZkIQKdkYLR4_XTAWvypcOtt5VwesjFuChWACdhq3LnTRzNVLgxeFogSXhfcGfMBV741d4uLDWVzBO9SubcB2R-hAF3WA6XZO0Mvd7fPNfTR_mj3cXM-jMklZF2mmSynSioFWMs64VExwAZoooVPCRSWKmGngIEFlDCpKCRW64CrmnFRMsgk62-S23r31ELq8MaGEui4suD7klHEZszSWyUBP_9CV670drlurLJWJSPigzjeq9C4EDzpvvWkK_5lTkq_Lzn_LHvDJNrJXDVQ_9LvaAVxsQGjXNYHf2fk_7gtN44kR</recordid><startdate>20130617</startdate><enddate>20130617</enddate><creator>Liu, Yang</creator><creator>Xu, Xiao-Hui</creator><creator>Chen, Qi</creator><creator>Wang, Tong</creator><creator>Deng, Cai-Yun</creator><creator>Song, Bao-Liang</creator><creator>Du, Jiu-Lin</creator><creator>Luo, Zhen-Ge</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7SN</scope><scope>7SS</scope><scope>7ST</scope><scope>7T5</scope><scope>7T7</scope><scope>7TM</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>SOI</scope><scope>7X8</scope></search><sort><creationdate>20130617</creationdate><title>Myosin Vb controls biogenesis of post-Golgi Rab10 carriers during axon development</title><author>Liu, Yang ; Xu, Xiao-Hui ; Chen, Qi ; Wang, Tong ; Deng, Cai-Yun ; Song, Bao-Liang ; Du, Jiu-Lin ; Luo, Zhen-Ge</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c453t-f3fc975d3efb92869b3767ef0b7f5067d7a23fe6e9eb83ed11017fa6b2660d393</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>631/378/2571</topic><topic>631/80/313/1525</topic><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Axons - 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Academic</collection><jtitle>Nature communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Liu, Yang</au><au>Xu, Xiao-Hui</au><au>Chen, Qi</au><au>Wang, Tong</au><au>Deng, Cai-Yun</au><au>Song, Bao-Liang</au><au>Du, Jiu-Lin</au><au>Luo, Zhen-Ge</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Myosin Vb controls biogenesis of post-Golgi Rab10 carriers during axon development</atitle><jtitle>Nature communications</jtitle><stitle>Nat Commun</stitle><addtitle>Nat Commun</addtitle><date>2013-06-17</date><risdate>2013</risdate><volume>4</volume><issue>1</issue><spage>2005</spage><epage>2005</epage><pages>2005-2005</pages><artnum>2005</artnum><issn>2041-1723</issn><eissn>2041-1723</eissn><abstract>Polarized membrane addition is crucial for axon development and elongation during neuronal morphogenesis. This process is believed to be regulated by directed membrane trafficking of Rab10-containing post-Golgi carriers. However, the mechanisms underlying the biogenesis of these carriers remain unclear. Here, we report that Rab10 interaction with myosin Vb (MYO5B) determines the formation of Rab10 carriers and is important for axon development. Rab10 interacts with the exon D-encoded domain of MYO5B. Downregulating the expression of MYO5B (+D) or blocking its interaction with Rab10 impairs the fission of Rab10 vesicles from trans-Golgi membranes, causes a decrease in the number of Rab10 transport carriers and inhibits axon development in cultured hippocampal neurons. Furthermore, the MYO5B–Rab10 system is required for axon development of vertebrate neocortical neurons or zebrafish retinal ganglion cells
in vivo
. Thus, specific interaction between Rab10 and MYO5B controls the formation of Rab10 vesicles, which is required for axon development.
Polarized membrane addition during axon development requires post-Golgi Rab10 carriers, whose biogenesis mechanisms remain unknown. This work shows that specific interaction between Rab10 and MYO5B controls formation of the Rab10 carriers, and this process is essential for neuronal polarization.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>23770993</pmid><doi>10.1038/ncomms3005</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 631/378/2571 631/80/313/1525 Amino Acid Sequence Animals Axons - drug effects Axons - metabolism Axons - ultrastructure Cell Polarity - drug effects Exons - genetics Fibroblasts - cytology Fibroblasts - drug effects Fibroblasts - metabolism Golgi Apparatus - drug effects Golgi Apparatus - metabolism Guanosine Triphosphate - metabolism HEK293 Cells Hippocampus - cytology Humanities and Social Sciences Humans Molecular Sequence Data Morpholinos - pharmacology multidisciplinary Myosins - chemistry Myosins - metabolism Optic Nerve - drug effects Optic Nerve - growth & development Optic Nerve - metabolism Protein Binding - drug effects rab GTP-Binding Proteins - metabolism Rats Retinal Ganglion Cells - cytology Retinal Ganglion Cells - drug effects Retinal Ganglion Cells - metabolism RNA, Small Interfering - metabolism Science Science (multidisciplinary) trans-Golgi Network - drug effects trans-Golgi Network - metabolism Transport Vesicles - drug effects Transport Vesicles - metabolism Transport Vesicles - ultrastructure Zebrafish Zebrafish Proteins - chemistry Zebrafish Proteins - metabolism |
| title | Myosin Vb controls biogenesis of post-Golgi Rab10 carriers during axon development |
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