Intact structure of EGAM1 homeoproteins and basic amino acid residues in the common homeodomain of EGAM1 and EGAM1C contribute to their nuclear localization in mouse embryonic stem cells

Recently, we identified the structurally related homeoproteins EGAM1, EGAM1N, and EGAM1C in both preimplantation mouse embryos and mouse embryonic stem (ES) cells. These EGAM1 homeoproteins act as positive or negative regulators of differentiation and cell growth in mouse ES cells, such that these p...

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Veröffentlicht in:	Journal of bioscience and bioengineering 2013-08, Vol.116 (2), p.141-146
Hauptverfasser:	Sato, Sho, Morita, Sanae, Iha, Momoe, Mori, Yuki, Sugawara, Saiko, Kasuga, Kano, Kojima, Ikuo, Ozaki, Noriaki, Muraguchi, Hajime, Okano, Keiju, Iwashita, Jun, Murata, Jun, Hosaka, Masahiro, Kobayashi, Masayuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Amino Acids, Basic - chemistry Animals Biological and medical sciences Biotechnology Cell Line Cell Nucleus - metabolism Crxos1 Egam1 Embryonic stem cells Embryonic Stem Cells - metabolism Fundamental and applied biological sciences. Psychology Green Fluorescent Proteins - genetics Homeodomain Proteins - chemistry Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Homeoprotein Mice Molecular Sequence Data NIH 3T3 Cells Nuclear localization signal Nuclear Localization Signals Protein Structure, Tertiary
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