Inhibition of quorum sensing in gram-negative bacteria by alkylamine-modified cyclodextrins

N-Acylhomoserine lactones (AHLs) are used as quorum-sensing (QS) signals by gram-negative bacteria. We have reported that the cyclic oligosaccharides known as cyclodextrins (CDs) form inclusion complexes with AHLs and disrupt QS signaling. In this study, a series of CD derivatives were designed and...

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Veröffentlicht in:	Journal of bioscience and bioengineering 2013-08, Vol.116 (2), p.175-179
Hauptverfasser:	Morohoshi, Tomohiro, Tokita, Kazuho, Ito, Satoshi, Saito, Yuki, Maeda, Saki, Kato, Norihiro, Ikeda, Tsukasa
Format:	Artikel
Sprache:	eng
Schlagworte:	Acyl-Butyrolactones - chemistry Acylhomoserine lactone Biological and medical sciences Biotechnology carbon Chromobacterium - drug effects Chromobacterium - metabolism Chromobacterium violaceum Cyclodextrin cyclodextrins Cyclodextrins - chemistry Cyclodextrins - pharmacology Fundamental and applied biological sciences. Psychology Gram-negative bacteria Gram-Negative Bacteria - drug effects Gram-Negative Bacteria - metabolism Inclusion complex Inhibition lactones nuclear magnetic resonance spectroscopy oligosaccharides Prodigiosin - biosynthesis Pseudomonas aeruginosa Pseudomonas aeruginosa - drug effects Pseudomonas aeruginosa - metabolism Quorum sensing Quorum Sensing - drug effects Serratia marcescens Serratia marcescens - drug effects Serratia marcescens - metabolism
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