The incidence of endometrial cancer in women with BRCA1 and BRCA2 mutations: An international prospective cohort study

Abstract Objective To evaluate the risk of endometrial cancer in women who carry a mutation in the BRCA1 or the BRCA2 gene. Methods We followed 4456 women with a BRCA1 or a BRCA2 mutation for incident cases of endometrial cancer. The incidence of endometrial cancer was estimated per 100,000 women pe...

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Veröffentlicht in:	Gynecologic oncology 2013-07, Vol.130 (1), p.127-131
Hauptverfasser:	Segev, Yakir, Iqbal, Javaid, Lubinski, Jan, Gronwald, Jacek, Lynch, Henry T, Moller, Pal, Ghadirian, Parviz, Rosen, Barry, Tung, Nadine, Kim-Sing, Charmaine, Foulkes, William D, Neuhausen, Susan L, Senter, Leigha, Singer, Christian F, Karlan, Beth, Ping, Sun, Narod, Steven A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antineoplastic Agents, Hormonal - administration & dosage Antineoplastic Agents, Hormonal - adverse effects BRCA1 BRCA2 Cohort Studies Endometrial cancer Endometrial Neoplasms - epidemiology Endometrial Neoplasms - genetics Endometrial Neoplasms - surgery Europe - epidemiology Female Genes, BRCA1 Genes, BRCA2 Germ-Line Mutation Hematology, Oncology and Palliative Medicine Humans Incidence Middle Aged North America - epidemiology Obstetrics and Gynecology Ovariectomy Proportional Hazards Models Prospective Studies Tamoxifen - administration & dosage Tamoxifen - adverse effects
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