Cancer risk associated with STK11/LKB1 germline mutations in Peutz–Jeghers syndrome patients: Results of an Italian multicenter study

Abstract Background Germline mutations in the STK11/LKB1 gene cause Peutz–Jeghers syndrome, an autosomal-dominantly inherited condition characterized by mucocutaneous pigmentation, hamartomatous gastrointestinal polyposis, and an increased risk for various malignancies. We here report the results of...

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Veröffentlicht in:	Digestive and liver disease 2013-07, Vol.45 (7), p.606-611
Hauptverfasser:	Resta, Nicoletta, Pierannunzio, Daniela, Lenato, Gennaro Mariano, Stella, Alessandro, Capocaccia, Riccardo, Bagnulo, Rosanna, Lastella, Patrizia, Susca, Francesco Claudio, Bozzao, Cristina, Loconte, Daria Carmela, Sabbà, Carlo, Urso, Emanuele, Sala, Paola, Fornasarig, Mara, Grammatico, Paola, Piepoli, Ada, Host, Cristina, Turchetti, Daniela, Viel, Alessandra, Memo, Luigi, Giunti, Laura, Stigliano, Vittoria, Varesco, Liliana, Bertario, Lucio, Genuardi, Maurizio, Lucci Cordisco, Emanuela, Tibiletti, Maria Grazia, Di Gregorio, Carmela, Andriulli, Angelo, Ponz de Leon, Maurizio
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Breast Neoplasms - epidemiology Breast Neoplasms - genetics Child Child, Preschool Cohort Studies Female Gastroenterology and Hepatology Gastrointestinal Neoplasms - epidemiology Gastrointestinal Neoplasms - genetics Genetic Predisposition to Disease Genital Neoplasms, Female - epidemiology Genital Neoplasms, Female - genetics Germ-Line Mutation - genetics Hamartomatous polyposis Humans Italy Kaplan-Meier Estimate Male Middle Aged Neoplasms Pancreatic Neoplasms - epidemiology Pancreatic Neoplasms - genetics Peutz-Jeghers Syndrome - epidemiology Peutz-Jeghers Syndrome - genetics Peutz–Jeghers syndrome Phenotype Protein-Serine-Threonine Kinases - genetics Retrospective Studies Risk Factors Sex Distribution Surveillance protocol Uterine Cervical Neoplasms - epidemiology Uterine Cervical Neoplasms - genetics Young Adult
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