Cancer risk associated with STK11/LKB1 germline mutations in Peutz–Jeghers syndrome patients: Results of an Italian multicenter study
Abstract Background Germline mutations in the STK11/LKB1 gene cause Peutz–Jeghers syndrome, an autosomal-dominantly inherited condition characterized by mucocutaneous pigmentation, hamartomatous gastrointestinal polyposis, and an increased risk for various malignancies. We here report the results of...
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| creator | Resta, Nicoletta Pierannunzio, Daniela Lenato, Gennaro Mariano Stella, Alessandro Capocaccia, Riccardo Bagnulo, Rosanna Lastella, Patrizia Susca, Francesco Claudio Bozzao, Cristina Loconte, Daria Carmela Sabbà, Carlo Urso, Emanuele Sala, Paola Fornasarig, Mara Grammatico, Paola Piepoli, Ada Host, Cristina Turchetti, Daniela Viel, Alessandra Memo, Luigi Giunti, Laura Stigliano, Vittoria Varesco, Liliana Bertario, Lucio Genuardi, Maurizio Lucci Cordisco, Emanuela Tibiletti, Maria Grazia Di Gregorio, Carmela Andriulli, Angelo Ponz de Leon, Maurizio |
| description | Abstract Background Germline mutations in the STK11/LKB1 gene cause Peutz–Jeghers syndrome, an autosomal-dominantly inherited condition characterized by mucocutaneous pigmentation, hamartomatous gastrointestinal polyposis, and an increased risk for various malignancies. We here report the results of the first Italian collaborative study on Peutz–Jeghers syndrome. Aims To assess cancer risks in a large homogenous cohort of patients with Peutz–Jeghers syndrome, carrying, in large majority, an identified STK11/LKB1 mutation. Methods One-hundred and nineteen patients with Peutz–Jeghers syndrome, ascertained in sixteen different Italian centres, were enrolled in a retrospective cohort study. Relative and cumulative cancer risks and genotype–phenotype correlations were evaluated. Results 36 malignant tumours were found in 31/119 (29 STK11/LKB1 mutation carriers) patients. The mean age at first cancer diagnosis was 41 years. The relative overall cancer risk was 15.1 with a significantly higher risk ( p < 0.001) in females (22.0) than in males (8.6). Highly increased relative risks were present for gastrointestinal (126.2) and gynaecological cancers (27.7), in particular for pancreatic (139.7) and cervical cancer (55.6). The Kaplan–Meier estimates for overall cumulative cancer risks were 20%, 43%, 71%, and 89%, at age 40, 50, 60 and 65 years, respectively. Conclusion Peutz–Jeghers syndrome entails markedly elevated cancer risks, mainly for pancreatic and cervical cancers. This study provides a helpful reference for improving current surveillance protocols. |
| doi_str_mv | 10.1016/j.dld.2012.12.018 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1369232988</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S1590865812004963</els_id><sourcerecordid>1369232988</sourcerecordid><originalsourceid>FETCH-LOGICAL-c408t-372dce88203bd6a56a482b4a6492c180d42a977c65896fdbf563f6a9504b083a3</originalsourceid><addsrcrecordid>eNp9kstuFDEQRVsIRB7wAWyQl2x64ke3xw0SUhjxCBkJRMLa8tjViSf9GFxuomHFjg_gD_kSajSBBQukksqy7r1WnXJRPBF8JrjQJ-tZ6MJMciFnVFyYe8WhMHNTqlrL-3SuG14aXZuD4ghxzbkUuuYPiwOpKlHXhh8WPxZu8JBYinjDHOLoo8sQ2G3M1-zi8lyIk-X5K8GuIPVdHID1U3Y5jgOyOLCPMOVvv77_fA9X15CQ4XYIaeyBbUgDQ8bn7BPg1GVkY8vcwM6y6yL1nu6iJwU9jXkK20fFg9Z1CI_v-nHx-c3ry8W7cvnh7dnidFn6iptcqrkMHoyRXK2CdrV2lZGryumqkV4YHirpmvnc08yNbsOqrbVqtWtqXq24UU4dF8_2uZs0fpkAs-0jeug6N8A4oRVKN1LJxhiSir3UpxExQWs3KfYuba3gdsffri3xtzv-lor4k-fpXfy06iH8dfwBToIXewHQkF8jJIueSHkIMYHPNozxv_Ev_3F7Wkr0rruBLeB6nNJA9KywSAZ7sfsAu_0LyXnVaKV-AyhSrFw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1369232988</pqid></control><display><type>article</type><title>Cancer risk associated with STK11/LKB1 germline mutations in Peutz–Jeghers syndrome patients: Results of an Italian multicenter study</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><creator>Resta, Nicoletta ; Pierannunzio, Daniela ; Lenato, Gennaro Mariano ; Stella, Alessandro ; Capocaccia, Riccardo ; Bagnulo, Rosanna ; Lastella, Patrizia ; Susca, Francesco Claudio ; Bozzao, Cristina ; Loconte, Daria Carmela ; Sabbà, Carlo ; Urso, Emanuele ; Sala, Paola ; Fornasarig, Mara ; Grammatico, Paola ; Piepoli, Ada ; Host, Cristina ; Turchetti, Daniela ; Viel, Alessandra ; Memo, Luigi ; Giunti, Laura ; Stigliano, Vittoria ; Varesco, Liliana ; Bertario, Lucio ; Genuardi, Maurizio ; Lucci Cordisco, Emanuela ; Tibiletti, Maria Grazia ; Di Gregorio, Carmela ; Andriulli, Angelo ; Ponz de Leon, Maurizio</creator><creatorcontrib>Resta, Nicoletta ; Pierannunzio, Daniela ; Lenato, Gennaro Mariano ; Stella, Alessandro ; Capocaccia, Riccardo ; Bagnulo, Rosanna ; Lastella, Patrizia ; Susca, Francesco Claudio ; Bozzao, Cristina ; Loconte, Daria Carmela ; Sabbà, Carlo ; Urso, Emanuele ; Sala, Paola ; Fornasarig, Mara ; Grammatico, Paola ; Piepoli, Ada ; Host, Cristina ; Turchetti, Daniela ; Viel, Alessandra ; Memo, Luigi ; Giunti, Laura ; Stigliano, Vittoria ; Varesco, Liliana ; Bertario, Lucio ; Genuardi, Maurizio ; Lucci Cordisco, Emanuela ; Tibiletti, Maria Grazia ; Di Gregorio, Carmela ; Andriulli, Angelo ; Ponz de Leon, Maurizio ; AIFEG</creatorcontrib><description>Abstract Background Germline mutations in the STK11/LKB1 gene cause Peutz–Jeghers syndrome, an autosomal-dominantly inherited condition characterized by mucocutaneous pigmentation, hamartomatous gastrointestinal polyposis, and an increased risk for various malignancies. We here report the results of the first Italian collaborative study on Peutz–Jeghers syndrome. Aims To assess cancer risks in a large homogenous cohort of patients with Peutz–Jeghers syndrome, carrying, in large majority, an identified STK11/LKB1 mutation. Methods One-hundred and nineteen patients with Peutz–Jeghers syndrome, ascertained in sixteen different Italian centres, were enrolled in a retrospective cohort study. Relative and cumulative cancer risks and genotype–phenotype correlations were evaluated. Results 36 malignant tumours were found in 31/119 (29 STK11/LKB1 mutation carriers) patients. The mean age at first cancer diagnosis was 41 years. The relative overall cancer risk was 15.1 with a significantly higher risk ( p < 0.001) in females (22.0) than in males (8.6). Highly increased relative risks were present for gastrointestinal (126.2) and gynaecological cancers (27.7), in particular for pancreatic (139.7) and cervical cancer (55.6). The Kaplan–Meier estimates for overall cumulative cancer risks were 20%, 43%, 71%, and 89%, at age 40, 50, 60 and 65 years, respectively. Conclusion Peutz–Jeghers syndrome entails markedly elevated cancer risks, mainly for pancreatic and cervical cancers. This study provides a helpful reference for improving current surveillance protocols.</description><identifier>ISSN: 1590-8658</identifier><identifier>EISSN: 1878-3562</identifier><identifier>DOI: 10.1016/j.dld.2012.12.018</identifier><identifier>PMID: 23415580</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Adolescent ; Adult ; Aged ; Breast Neoplasms - epidemiology ; Breast Neoplasms - genetics ; Child ; Child, Preschool ; Cohort Studies ; Female ; Gastroenterology and Hepatology ; Gastrointestinal Neoplasms - epidemiology ; Gastrointestinal Neoplasms - genetics ; Genetic Predisposition to Disease ; Genital Neoplasms, Female - epidemiology ; Genital Neoplasms, Female - genetics ; Germ-Line Mutation - genetics ; Hamartomatous polyposis ; Humans ; Italy ; Kaplan-Meier Estimate ; Male ; Middle Aged ; Neoplasms ; Pancreatic Neoplasms - epidemiology ; Pancreatic Neoplasms - genetics ; Peutz-Jeghers Syndrome - epidemiology ; Peutz-Jeghers Syndrome - genetics ; Peutz–Jeghers syndrome ; Phenotype ; Protein-Serine-Threonine Kinases - genetics ; Retrospective Studies ; Risk Factors ; Sex Distribution ; Surveillance protocol ; Uterine Cervical Neoplasms - epidemiology ; Uterine Cervical Neoplasms - genetics ; Young Adult</subject><ispartof>Digestive and liver disease, 2013-07, Vol.45 (7), p.606-611</ispartof><rights>Editrice Gastroenterologica Italiana S.r.l.</rights><rights>2013 Editrice Gastroenterologica Italiana S.r.l.</rights><rights>Copyright © 2013 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c408t-372dce88203bd6a56a482b4a6492c180d42a977c65896fdbf563f6a9504b083a3</citedby><cites>FETCH-LOGICAL-c408t-372dce88203bd6a56a482b4a6492c180d42a977c65896fdbf563f6a9504b083a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.dld.2012.12.018$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23415580$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Resta, Nicoletta</creatorcontrib><creatorcontrib>Pierannunzio, Daniela</creatorcontrib><creatorcontrib>Lenato, Gennaro Mariano</creatorcontrib><creatorcontrib>Stella, Alessandro</creatorcontrib><creatorcontrib>Capocaccia, Riccardo</creatorcontrib><creatorcontrib>Bagnulo, Rosanna</creatorcontrib><creatorcontrib>Lastella, Patrizia</creatorcontrib><creatorcontrib>Susca, Francesco Claudio</creatorcontrib><creatorcontrib>Bozzao, Cristina</creatorcontrib><creatorcontrib>Loconte, Daria Carmela</creatorcontrib><creatorcontrib>Sabbà, Carlo</creatorcontrib><creatorcontrib>Urso, Emanuele</creatorcontrib><creatorcontrib>Sala, Paola</creatorcontrib><creatorcontrib>Fornasarig, Mara</creatorcontrib><creatorcontrib>Grammatico, Paola</creatorcontrib><creatorcontrib>Piepoli, Ada</creatorcontrib><creatorcontrib>Host, Cristina</creatorcontrib><creatorcontrib>Turchetti, Daniela</creatorcontrib><creatorcontrib>Viel, Alessandra</creatorcontrib><creatorcontrib>Memo, Luigi</creatorcontrib><creatorcontrib>Giunti, Laura</creatorcontrib><creatorcontrib>Stigliano, Vittoria</creatorcontrib><creatorcontrib>Varesco, Liliana</creatorcontrib><creatorcontrib>Bertario, Lucio</creatorcontrib><creatorcontrib>Genuardi, Maurizio</creatorcontrib><creatorcontrib>Lucci Cordisco, Emanuela</creatorcontrib><creatorcontrib>Tibiletti, Maria Grazia</creatorcontrib><creatorcontrib>Di Gregorio, Carmela</creatorcontrib><creatorcontrib>Andriulli, Angelo</creatorcontrib><creatorcontrib>Ponz de Leon, Maurizio</creatorcontrib><creatorcontrib>AIFEG</creatorcontrib><title>Cancer risk associated with STK11/LKB1 germline mutations in Peutz–Jeghers syndrome patients: Results of an Italian multicenter study</title><title>Digestive and liver disease</title><addtitle>Dig Liver Dis</addtitle><description>Abstract Background Germline mutations in the STK11/LKB1 gene cause Peutz–Jeghers syndrome, an autosomal-dominantly inherited condition characterized by mucocutaneous pigmentation, hamartomatous gastrointestinal polyposis, and an increased risk for various malignancies. We here report the results of the first Italian collaborative study on Peutz–Jeghers syndrome. Aims To assess cancer risks in a large homogenous cohort of patients with Peutz–Jeghers syndrome, carrying, in large majority, an identified STK11/LKB1 mutation. Methods One-hundred and nineteen patients with Peutz–Jeghers syndrome, ascertained in sixteen different Italian centres, were enrolled in a retrospective cohort study. Relative and cumulative cancer risks and genotype–phenotype correlations were evaluated. Results 36 malignant tumours were found in 31/119 (29 STK11/LKB1 mutation carriers) patients. The mean age at first cancer diagnosis was 41 years. The relative overall cancer risk was 15.1 with a significantly higher risk ( p < 0.001) in females (22.0) than in males (8.6). Highly increased relative risks were present for gastrointestinal (126.2) and gynaecological cancers (27.7), in particular for pancreatic (139.7) and cervical cancer (55.6). The Kaplan–Meier estimates for overall cumulative cancer risks were 20%, 43%, 71%, and 89%, at age 40, 50, 60 and 65 years, respectively. Conclusion Peutz–Jeghers syndrome entails markedly elevated cancer risks, mainly for pancreatic and cervical cancers. This study provides a helpful reference for improving current surveillance protocols.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Breast Neoplasms - epidemiology</subject><subject>Breast Neoplasms - genetics</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Cohort Studies</subject><subject>Female</subject><subject>Gastroenterology and Hepatology</subject><subject>Gastrointestinal Neoplasms - epidemiology</subject><subject>Gastrointestinal Neoplasms - genetics</subject><subject>Genetic Predisposition to Disease</subject><subject>Genital Neoplasms, Female - epidemiology</subject><subject>Genital Neoplasms, Female - genetics</subject><subject>Germ-Line Mutation - genetics</subject><subject>Hamartomatous polyposis</subject><subject>Humans</subject><subject>Italy</subject><subject>Kaplan-Meier Estimate</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neoplasms</subject><subject>Pancreatic Neoplasms - epidemiology</subject><subject>Pancreatic Neoplasms - genetics</subject><subject>Peutz-Jeghers Syndrome - epidemiology</subject><subject>Peutz-Jeghers Syndrome - genetics</subject><subject>Peutz–Jeghers syndrome</subject><subject>Phenotype</subject><subject>Protein-Serine-Threonine Kinases - genetics</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Sex Distribution</subject><subject>Surveillance protocol</subject><subject>Uterine Cervical Neoplasms - epidemiology</subject><subject>Uterine Cervical Neoplasms - genetics</subject><subject>Young Adult</subject><issn>1590-8658</issn><issn>1878-3562</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kstuFDEQRVsIRB7wAWyQl2x64ke3xw0SUhjxCBkJRMLa8tjViSf9GFxuomHFjg_gD_kSajSBBQukksqy7r1WnXJRPBF8JrjQJ-tZ6MJMciFnVFyYe8WhMHNTqlrL-3SuG14aXZuD4ghxzbkUuuYPiwOpKlHXhh8WPxZu8JBYinjDHOLoo8sQ2G3M1-zi8lyIk-X5K8GuIPVdHID1U3Y5jgOyOLCPMOVvv77_fA9X15CQ4XYIaeyBbUgDQ8bn7BPg1GVkY8vcwM6y6yL1nu6iJwU9jXkK20fFg9Z1CI_v-nHx-c3ry8W7cvnh7dnidFn6iptcqrkMHoyRXK2CdrV2lZGryumqkV4YHirpmvnc08yNbsOqrbVqtWtqXq24UU4dF8_2uZs0fpkAs-0jeug6N8A4oRVKN1LJxhiSir3UpxExQWs3KfYuba3gdsffri3xtzv-lor4k-fpXfy06iH8dfwBToIXewHQkF8jJIueSHkIMYHPNozxv_Ev_3F7Wkr0rruBLeB6nNJA9KywSAZ7sfsAu_0LyXnVaKV-AyhSrFw</recordid><startdate>20130701</startdate><enddate>20130701</enddate><creator>Resta, Nicoletta</creator><creator>Pierannunzio, Daniela</creator><creator>Lenato, Gennaro Mariano</creator><creator>Stella, Alessandro</creator><creator>Capocaccia, Riccardo</creator><creator>Bagnulo, Rosanna</creator><creator>Lastella, Patrizia</creator><creator>Susca, Francesco Claudio</creator><creator>Bozzao, Cristina</creator><creator>Loconte, Daria Carmela</creator><creator>Sabbà, Carlo</creator><creator>Urso, Emanuele</creator><creator>Sala, Paola</creator><creator>Fornasarig, Mara</creator><creator>Grammatico, Paola</creator><creator>Piepoli, Ada</creator><creator>Host, Cristina</creator><creator>Turchetti, Daniela</creator><creator>Viel, Alessandra</creator><creator>Memo, Luigi</creator><creator>Giunti, Laura</creator><creator>Stigliano, Vittoria</creator><creator>Varesco, Liliana</creator><creator>Bertario, Lucio</creator><creator>Genuardi, Maurizio</creator><creator>Lucci Cordisco, Emanuela</creator><creator>Tibiletti, Maria Grazia</creator><creator>Di Gregorio, Carmela</creator><creator>Andriulli, Angelo</creator><creator>Ponz de Leon, Maurizio</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20130701</creationdate><title>Cancer risk associated with STK11/LKB1 germline mutations in Peutz–Jeghers syndrome patients: Results of an Italian multicenter study</title><author>Resta, Nicoletta ; Pierannunzio, Daniela ; Lenato, Gennaro Mariano ; Stella, Alessandro ; Capocaccia, Riccardo ; Bagnulo, Rosanna ; Lastella, Patrizia ; Susca, Francesco Claudio ; Bozzao, Cristina ; Loconte, Daria Carmela ; Sabbà, Carlo ; Urso, Emanuele ; Sala, Paola ; Fornasarig, Mara ; Grammatico, Paola ; Piepoli, Ada ; Host, Cristina ; Turchetti, Daniela ; Viel, Alessandra ; Memo, Luigi ; Giunti, Laura ; Stigliano, Vittoria ; Varesco, Liliana ; Bertario, Lucio ; Genuardi, Maurizio ; Lucci Cordisco, Emanuela ; Tibiletti, Maria Grazia ; Di Gregorio, Carmela ; Andriulli, Angelo ; Ponz de Leon, Maurizio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c408t-372dce88203bd6a56a482b4a6492c180d42a977c65896fdbf563f6a9504b083a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Breast Neoplasms - 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Academic</collection><jtitle>Digestive and liver disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Resta, Nicoletta</au><au>Pierannunzio, Daniela</au><au>Lenato, Gennaro Mariano</au><au>Stella, Alessandro</au><au>Capocaccia, Riccardo</au><au>Bagnulo, Rosanna</au><au>Lastella, Patrizia</au><au>Susca, Francesco Claudio</au><au>Bozzao, Cristina</au><au>Loconte, Daria Carmela</au><au>Sabbà, Carlo</au><au>Urso, Emanuele</au><au>Sala, Paola</au><au>Fornasarig, Mara</au><au>Grammatico, Paola</au><au>Piepoli, Ada</au><au>Host, Cristina</au><au>Turchetti, Daniela</au><au>Viel, Alessandra</au><au>Memo, Luigi</au><au>Giunti, Laura</au><au>Stigliano, Vittoria</au><au>Varesco, Liliana</au><au>Bertario, Lucio</au><au>Genuardi, Maurizio</au><au>Lucci Cordisco, Emanuela</au><au>Tibiletti, Maria Grazia</au><au>Di Gregorio, Carmela</au><au>Andriulli, Angelo</au><au>Ponz de Leon, Maurizio</au><aucorp>AIFEG</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cancer risk associated with STK11/LKB1 germline mutations in Peutz–Jeghers syndrome patients: Results of an Italian multicenter study</atitle><jtitle>Digestive and liver disease</jtitle><addtitle>Dig Liver Dis</addtitle><date>2013-07-01</date><risdate>2013</risdate><volume>45</volume><issue>7</issue><spage>606</spage><epage>611</epage><pages>606-611</pages><issn>1590-8658</issn><eissn>1878-3562</eissn><abstract>Abstract Background Germline mutations in the STK11/LKB1 gene cause Peutz–Jeghers syndrome, an autosomal-dominantly inherited condition characterized by mucocutaneous pigmentation, hamartomatous gastrointestinal polyposis, and an increased risk for various malignancies. We here report the results of the first Italian collaborative study on Peutz–Jeghers syndrome. Aims To assess cancer risks in a large homogenous cohort of patients with Peutz–Jeghers syndrome, carrying, in large majority, an identified STK11/LKB1 mutation. Methods One-hundred and nineteen patients with Peutz–Jeghers syndrome, ascertained in sixteen different Italian centres, were enrolled in a retrospective cohort study. Relative and cumulative cancer risks and genotype–phenotype correlations were evaluated. Results 36 malignant tumours were found in 31/119 (29 STK11/LKB1 mutation carriers) patients. The mean age at first cancer diagnosis was 41 years. The relative overall cancer risk was 15.1 with a significantly higher risk ( p < 0.001) in females (22.0) than in males (8.6). Highly increased relative risks were present for gastrointestinal (126.2) and gynaecological cancers (27.7), in particular for pancreatic (139.7) and cervical cancer (55.6). The Kaplan–Meier estimates for overall cumulative cancer risks were 20%, 43%, 71%, and 89%, at age 40, 50, 60 and 65 years, respectively. Conclusion Peutz–Jeghers syndrome entails markedly elevated cancer risks, mainly for pancreatic and cervical cancers. This study provides a helpful reference for improving current surveillance protocols.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>23415580</pmid><doi>10.1016/j.dld.2012.12.018</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1590-8658 |
| ispartof | Digestive and liver disease, 2013-07, Vol.45 (7), p.606-611 |
| issn | 1590-8658 1878-3562 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1369232988 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Adolescent Adult Aged Breast Neoplasms - epidemiology Breast Neoplasms - genetics Child Child, Preschool Cohort Studies Female Gastroenterology and Hepatology Gastrointestinal Neoplasms - epidemiology Gastrointestinal Neoplasms - genetics Genetic Predisposition to Disease Genital Neoplasms, Female - epidemiology Genital Neoplasms, Female - genetics Germ-Line Mutation - genetics Hamartomatous polyposis Humans Italy Kaplan-Meier Estimate Male Middle Aged Neoplasms Pancreatic Neoplasms - epidemiology Pancreatic Neoplasms - genetics Peutz-Jeghers Syndrome - epidemiology Peutz-Jeghers Syndrome - genetics Peutz–Jeghers syndrome Phenotype Protein-Serine-Threonine Kinases - genetics Retrospective Studies Risk Factors Sex Distribution Surveillance protocol Uterine Cervical Neoplasms - epidemiology Uterine Cervical Neoplasms - genetics Young Adult |
| title | Cancer risk associated with STK11/LKB1 germline mutations in Peutz–Jeghers syndrome patients: Results of an Italian multicenter study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-11T22%3A34%3A03IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Cancer%20risk%20associated%20with%20STK11/LKB1%20germline%20mutations%20in%20Peutz%E2%80%93Jeghers%20syndrome%20patients:%20Results%20of%20an%20Italian%20multicenter%20study&rft.jtitle=Digestive%20and%20liver%20disease&rft.au=Resta,%20Nicoletta&rft.aucorp=AIFEG&rft.date=2013-07-01&rft.volume=45&rft.issue=7&rft.spage=606&rft.epage=611&rft.pages=606-611&rft.issn=1590-8658&rft.eissn=1878-3562&rft_id=info:doi/10.1016/j.dld.2012.12.018&rft_dat=%3Cproquest_cross%3E1369232988%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1369232988&rft_id=info:pmid/23415580&rft_els_id=1_s2_0_S1590865812004963&rfr_iscdi=true |