Warburg effect associated with transformed lymphoplasmacytic lymphoma to diffuse large B-cell lymphoma
Warburg effect is a rare metabolic complication in hematologic malignancies, commonly presented with lactic acidosis and hypoglycemia. Mechanism explained by abnormality of mitochondrial oxidative phosphorylation in cancer cells and energy production is mostly dependent on anaerobic respiration or g...
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| Veröffentlicht in: | The American journal of emergency medicine 2013-06, Vol.31 (6), p.999.e5-999.e6 |
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| container_title | The American journal of emergency medicine |
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| creator | Buppajarntham, Saranya, MD Junpaparp, Parichart, MD Kue-A-Pai, Pongsathorn, MD |
| description | Warburg effect is a rare metabolic complication in hematologic malignancies, commonly presented with lactic acidosis and hypoglycemia. Mechanism explained by abnormality of mitochondrial oxidative phosphorylation in cancer cells and energy production is mostly dependent on anaerobic respiration or glycolysis pathway to meet large tumor demand. We present a case with history of lymphoplasmacytic lymphoma and Waldenstörm macroglobulinemia, partial response to chemotherapy. Lymphoplasmacytic lymphoma transformed to diffuse large B-cell lymphoma, which is aggressive and rapid progression, leading to Warburg effect. Patient developed more than 10-cm retroperitoneal mass less than 1 year, and his symptoms were progressively worsening within 3 weeks. Warburg effect represents poor prognosis no matter with or without hypoglycemia. Treatment of choice is cytoreduction with early chemotherapy. Our patient died 2 days after Warburg effect occurred. |
| doi_str_mv | 10.1016/j.ajem.2013.01.038 |
| format | Article |
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Mechanism explained by abnormality of mitochondrial oxidative phosphorylation in cancer cells and energy production is mostly dependent on anaerobic respiration or glycolysis pathway to meet large tumor demand. We present a case with history of lymphoplasmacytic lymphoma and Waldenstörm macroglobulinemia, partial response to chemotherapy. Lymphoplasmacytic lymphoma transformed to diffuse large B-cell lymphoma, which is aggressive and rapid progression, leading to Warburg effect. Patient developed more than 10-cm retroperitoneal mass less than 1 year, and his symptoms were progressively worsening within 3 weeks. Warburg effect represents poor prognosis no matter with or without hypoglycemia. Treatment of choice is cytoreduction with early chemotherapy. Our patient died 2 days after Warburg effect occurred.</description><identifier>ISSN: 0735-6757</identifier><identifier>EISSN: 1532-8171</identifier><identifier>DOI: 10.1016/j.ajem.2013.01.038</identifier><identifier>PMID: 23478115</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Abdomen ; Acid production ; Acidosis, Lactic - diagnosis ; Acidosis, Lactic - etiology ; Acids ; Aged ; Anaerobic respiration ; Cancer ; Chemotherapy ; Drug therapy ; Emergency ; Emergency medical care ; Fatal Outcome ; Glucose ; Hospice care ; Humans ; Hypoglycemia ; Lymphoma ; Lymphoma, Large B-Cell, Diffuse - complications ; Lymphoma, Large B-Cell, Diffuse - pathology ; Male ; Mortality ; Phosphorylation ; Waldenstrom Macroglobulinemia - complications ; Waldenstrom Macroglobulinemia - pathology</subject><ispartof>The American journal of emergency medicine, 2013-06, Vol.31 (6), p.999.e5-999.e6</ispartof><rights>Elsevier Inc.</rights><rights>2013 Elsevier Inc.</rights><rights>Copyright Elsevier Limited 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c439t-5a1652772ace667ea98505e617a816ea5abda12940774c1a736a27b4ee31e6bf3</citedby><cites>FETCH-LOGICAL-c439t-5a1652772ace667ea98505e617a816ea5abda12940774c1a736a27b4ee31e6bf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1367081836?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995,64385,64387,64389,72469</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23478115$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Buppajarntham, Saranya, MD</creatorcontrib><creatorcontrib>Junpaparp, Parichart, MD</creatorcontrib><creatorcontrib>Kue-A-Pai, Pongsathorn, MD</creatorcontrib><title>Warburg effect associated with transformed lymphoplasmacytic lymphoma to diffuse large B-cell lymphoma</title><title>The American journal of emergency medicine</title><addtitle>Am J Emerg Med</addtitle><description>Warburg effect is a rare metabolic complication in hematologic malignancies, commonly presented with lactic acidosis and hypoglycemia. Mechanism explained by abnormality of mitochondrial oxidative phosphorylation in cancer cells and energy production is mostly dependent on anaerobic respiration or glycolysis pathway to meet large tumor demand. We present a case with history of lymphoplasmacytic lymphoma and Waldenstörm macroglobulinemia, partial response to chemotherapy. Lymphoplasmacytic lymphoma transformed to diffuse large B-cell lymphoma, which is aggressive and rapid progression, leading to Warburg effect. Patient developed more than 10-cm retroperitoneal mass less than 1 year, and his symptoms were progressively worsening within 3 weeks. Warburg effect represents poor prognosis no matter with or without hypoglycemia. Treatment of choice is cytoreduction with early chemotherapy. 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Mechanism explained by abnormality of mitochondrial oxidative phosphorylation in cancer cells and energy production is mostly dependent on anaerobic respiration or glycolysis pathway to meet large tumor demand. We present a case with history of lymphoplasmacytic lymphoma and Waldenstörm macroglobulinemia, partial response to chemotherapy. Lymphoplasmacytic lymphoma transformed to diffuse large B-cell lymphoma, which is aggressive and rapid progression, leading to Warburg effect. Patient developed more than 10-cm retroperitoneal mass less than 1 year, and his symptoms were progressively worsening within 3 weeks. Warburg effect represents poor prognosis no matter with or without hypoglycemia. Treatment of choice is cytoreduction with early chemotherapy. Our patient died 2 days after Warburg effect occurred.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>23478115</pmid><doi>10.1016/j.ajem.2013.01.038</doi></addata></record> |
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| subjects | Abdomen Acid production Acidosis, Lactic - diagnosis Acidosis, Lactic - etiology Acids Aged Anaerobic respiration Cancer Chemotherapy Drug therapy Emergency Emergency medical care Fatal Outcome Glucose Hospice care Humans Hypoglycemia Lymphoma Lymphoma, Large B-Cell, Diffuse - complications Lymphoma, Large B-Cell, Diffuse - pathology Male Mortality Phosphorylation Waldenstrom Macroglobulinemia - complications Waldenstrom Macroglobulinemia - pathology |
| title | Warburg effect associated with transformed lymphoplasmacytic lymphoma to diffuse large B-cell lymphoma |
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