The prenatal diagnosis of isolated fetal varix of the intra-abdominal umbilical vein is associated with favorable neonatal outcome at term: a case series
Objective Varix of the fetal intra-abdominal umbilical vein (VFIUV) has been reported to be associated with an increased risk of adverse perinatal outcome and especially with intra-uterine fetal demise (IUFD). Induction of preterm birth, as early as 32–34 weeks gestation has been suggested to minimi...
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| Veröffentlicht in: | Archives of gynecology and obstetrics 2013-07, Vol.288 (1), p.33-39 |
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| creator | Bas-Lando, Maayan Rabinowitz, Ron Samueloff, Arnon Latinsky, Boris Schimmel, Michael S. Chen, Ori Grisaru-Granovsky, Sorina |
| description | Objective
Varix of the fetal intra-abdominal umbilical vein (VFIUV) has been reported to be associated with an increased risk of adverse perinatal outcome and especially with intra-uterine fetal demise (IUFD). Induction of preterm birth, as early as 32–34 weeks gestation has been suggested to minimize this risk. We aimed to evaluate our center experience with the antenatal diagnosis of VFIUV and review the relevant literature.
Methods
This is a retrospective case series of all cases (between 2004 and 2009) where the sonographic antenatal diagnosis of VFIUV was registered at any gestational age (GA). Ultrasound, maternal and newborn electronic medical records were used. Descriptive statistics were employed as appropriated and correlation coefficient (
r
) calculated.
Results
We identified 24 women with fetuses, with isolated VFIUV (excluding one lost-to-follow-up). GA at diagnosis was 30.5 ± 4.4 weeks; 13 (56.5 %) cases were diagnosed |
| doi_str_mv | 10.1007/s00404-013-2743-x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1367886049</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1367886049</sourcerecordid><originalsourceid>FETCH-LOGICAL-c372t-b63cfcd5a2da7229679163695328eeb00c4854fe5aa1c3b0730a843d605c0ad63</originalsourceid><addsrcrecordid>eNp1kcFu1TAQRS0Eoq-FD2CDLLFhExjbieOwQxUUpEpsytqaOJPWVRI_bKd9fAp_i8MrICGxsuV77h3bl7EXAt4IgPZtAqihrkCoSra1qg6P2E7USlbQCvGY7aDb9qDbE3aa0i2AkMbop-xEKmU6WZsd-3F1Q3wfacGMEx88Xi8h-cTDyH0KE2Ya-EibdofRH7bzXBx-yREr7Icw-6WI69z7ybsNI78UK8eUgvO__Pc-3_AR70LEfiK-UDhOC2t2YSaOmWeK8zuO3GEinih6Ss_YkxGnRM8f1jP29eOHq_NP1eWXi8_n7y8rp1qZq14rN7qhQTlgK2Wn205opbtGSUPUA7jaNPVIDaJwqodWAZpaDRoaBzhodcZeH3P3MXxbKWU7--RomrBcdE1WKN2WX4O6K-irf9DbsMby_mSl1MIYYXRTKHGkXAwpRRrtPvoZ43crwG692WNvtvRmt97soXhePiSv_UzDH8fvogogj0Aq0nJN8e_o_6f-BI-1pSI</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2261881865</pqid></control><display><type>article</type><title>The prenatal diagnosis of isolated fetal varix of the intra-abdominal umbilical vein is associated with favorable neonatal outcome at term: a case series</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Bas-Lando, Maayan ; Rabinowitz, Ron ; Samueloff, Arnon ; Latinsky, Boris ; Schimmel, Michael S. ; Chen, Ori ; Grisaru-Granovsky, Sorina</creator><creatorcontrib>Bas-Lando, Maayan ; Rabinowitz, Ron ; Samueloff, Arnon ; Latinsky, Boris ; Schimmel, Michael S. ; Chen, Ori ; Grisaru-Granovsky, Sorina</creatorcontrib><description>Objective
Varix of the fetal intra-abdominal umbilical vein (VFIUV) has been reported to be associated with an increased risk of adverse perinatal outcome and especially with intra-uterine fetal demise (IUFD). Induction of preterm birth, as early as 32–34 weeks gestation has been suggested to minimize this risk. We aimed to evaluate our center experience with the antenatal diagnosis of VFIUV and review the relevant literature.
Methods
This is a retrospective case series of all cases (between 2004 and 2009) where the sonographic antenatal diagnosis of VFIUV was registered at any gestational age (GA). Ultrasound, maternal and newborn electronic medical records were used. Descriptive statistics were employed as appropriated and correlation coefficient (
r
) calculated.
Results
We identified 24 women with fetuses, with isolated VFIUV (excluding one lost-to-follow-up). GA at diagnosis was 30.5 ± 4.4 weeks; 13 (56.5 %) cases were diagnosed <32 weeks. The mean VFIUV diameter was 13 ± 2.9 (range 9–20) mm and turbulent flow was reported in 7 cases (30.4 %). GA at birth was 37 ± 2.5 weeks. The small for gestational age rate was 4 % (1/23), while no case of IUFD occurred. The group induction of labor rate was 65.2 %, while 43 % (10/23) due to the diagnosis of VFIUV alone: 17 % (4/23) preterm and 26 % (6/23) at term. The cesarean rate was 17 % (4/23) and NICU admission was required for five neonates (21.7 %). The preterm induction of birth was related to a significantly increased risk for cesarean and neonatal morbidity (
p
= 0.015;
p
= 0.029, respectively). The mode of delivery was not associated with the GA at diagnosis, size/type of flow of VFIUV (
r
= 0.101;
r
= 0.727;
r
= 0.671, respectively) overall (
r
) = 0.4. All fetuses were live-born with normal follow-up at 2–60 months.
Conclusion
Isolated VFIUV has a favorable perinatal outcome at term, unrelated to the structural and flow characteristics of VFIUV. We show that follow-up for growth abnormalities with no preterm induction of birth is a safe maternal and neonatal approach.</description><identifier>ISSN: 0932-0067</identifier><identifier>EISSN: 1432-0711</identifier><identifier>DOI: 10.1007/s00404-013-2743-x</identifier><identifier>PMID: 23389248</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Adult ; Birth Weight ; Cesarean Section ; Endocrinology ; Female ; Fetal Diseases - diagnostic imaging ; Fetuses ; Gestational Age ; Gynecology ; Health risk assessment ; Human Genetics ; Humans ; Intensive Care, Neonatal ; Labor, Induced ; Live Birth ; Maternal-Fetal Medicine ; Medicine ; Medicine & Public Health ; Obstetrics/Perinatology/Midwifery ; Pregnancy ; Premature Birth - etiology ; Retrospective Studies ; Term Birth ; Ultrasonography ; Umbilical Veins - abnormalities ; Varicose Veins - complications ; Varicose Veins - diagnostic imaging ; Young Adult</subject><ispartof>Archives of gynecology and obstetrics, 2013-07, Vol.288 (1), p.33-39</ispartof><rights>Springer-Verlag Berlin Heidelberg 2013</rights><rights>Archives of Gynecology and Obstetrics is a copyright of Springer, (2013). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-b63cfcd5a2da7229679163695328eeb00c4854fe5aa1c3b0730a843d605c0ad63</citedby><cites>FETCH-LOGICAL-c372t-b63cfcd5a2da7229679163695328eeb00c4854fe5aa1c3b0730a843d605c0ad63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00404-013-2743-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00404-013-2743-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23389248$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bas-Lando, Maayan</creatorcontrib><creatorcontrib>Rabinowitz, Ron</creatorcontrib><creatorcontrib>Samueloff, Arnon</creatorcontrib><creatorcontrib>Latinsky, Boris</creatorcontrib><creatorcontrib>Schimmel, Michael S.</creatorcontrib><creatorcontrib>Chen, Ori</creatorcontrib><creatorcontrib>Grisaru-Granovsky, Sorina</creatorcontrib><title>The prenatal diagnosis of isolated fetal varix of the intra-abdominal umbilical vein is associated with favorable neonatal outcome at term: a case series</title><title>Archives of gynecology and obstetrics</title><addtitle>Arch Gynecol Obstet</addtitle><addtitle>Arch Gynecol Obstet</addtitle><description>Objective
Varix of the fetal intra-abdominal umbilical vein (VFIUV) has been reported to be associated with an increased risk of adverse perinatal outcome and especially with intra-uterine fetal demise (IUFD). Induction of preterm birth, as early as 32–34 weeks gestation has been suggested to minimize this risk. We aimed to evaluate our center experience with the antenatal diagnosis of VFIUV and review the relevant literature.
Methods
This is a retrospective case series of all cases (between 2004 and 2009) where the sonographic antenatal diagnosis of VFIUV was registered at any gestational age (GA). Ultrasound, maternal and newborn electronic medical records were used. Descriptive statistics were employed as appropriated and correlation coefficient (
r
) calculated.
Results
We identified 24 women with fetuses, with isolated VFIUV (excluding one lost-to-follow-up). GA at diagnosis was 30.5 ± 4.4 weeks; 13 (56.5 %) cases were diagnosed <32 weeks. The mean VFIUV diameter was 13 ± 2.9 (range 9–20) mm and turbulent flow was reported in 7 cases (30.4 %). GA at birth was 37 ± 2.5 weeks. The small for gestational age rate was 4 % (1/23), while no case of IUFD occurred. The group induction of labor rate was 65.2 %, while 43 % (10/23) due to the diagnosis of VFIUV alone: 17 % (4/23) preterm and 26 % (6/23) at term. The cesarean rate was 17 % (4/23) and NICU admission was required for five neonates (21.7 %). The preterm induction of birth was related to a significantly increased risk for cesarean and neonatal morbidity (
p
= 0.015;
p
= 0.029, respectively). The mode of delivery was not associated with the GA at diagnosis, size/type of flow of VFIUV (
r
= 0.101;
r
= 0.727;
r
= 0.671, respectively) overall (
r
) = 0.4. All fetuses were live-born with normal follow-up at 2–60 months.
Conclusion
Isolated VFIUV has a favorable perinatal outcome at term, unrelated to the structural and flow characteristics of VFIUV. We show that follow-up for growth abnormalities with no preterm induction of birth is a safe maternal and neonatal approach.</description><subject>Adult</subject><subject>Birth Weight</subject><subject>Cesarean Section</subject><subject>Endocrinology</subject><subject>Female</subject><subject>Fetal Diseases - diagnostic imaging</subject><subject>Fetuses</subject><subject>Gestational Age</subject><subject>Gynecology</subject><subject>Health risk assessment</subject><subject>Human Genetics</subject><subject>Humans</subject><subject>Intensive Care, Neonatal</subject><subject>Labor, Induced</subject><subject>Live Birth</subject><subject>Maternal-Fetal Medicine</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Obstetrics/Perinatology/Midwifery</subject><subject>Pregnancy</subject><subject>Premature Birth - etiology</subject><subject>Retrospective Studies</subject><subject>Term Birth</subject><subject>Ultrasonography</subject><subject>Umbilical Veins - abnormalities</subject><subject>Varicose Veins - complications</subject><subject>Varicose Veins - diagnostic imaging</subject><subject>Young Adult</subject><issn>0932-0067</issn><issn>1432-0711</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kcFu1TAQRS0Eoq-FD2CDLLFhExjbieOwQxUUpEpsytqaOJPWVRI_bKd9fAp_i8MrICGxsuV77h3bl7EXAt4IgPZtAqihrkCoSra1qg6P2E7USlbQCvGY7aDb9qDbE3aa0i2AkMbop-xEKmU6WZsd-3F1Q3wfacGMEx88Xi8h-cTDyH0KE2Ya-EibdofRH7bzXBx-yREr7Icw-6WI69z7ybsNI78UK8eUgvO__Pc-3_AR70LEfiK-UDhOC2t2YSaOmWeK8zuO3GEinih6Ss_YkxGnRM8f1jP29eOHq_NP1eWXi8_n7y8rp1qZq14rN7qhQTlgK2Wn205opbtGSUPUA7jaNPVIDaJwqodWAZpaDRoaBzhodcZeH3P3MXxbKWU7--RomrBcdE1WKN2WX4O6K-irf9DbsMby_mSl1MIYYXRTKHGkXAwpRRrtPvoZ43crwG692WNvtvRmt97soXhePiSv_UzDH8fvogogj0Aq0nJN8e_o_6f-BI-1pSI</recordid><startdate>20130701</startdate><enddate>20130701</enddate><creator>Bas-Lando, Maayan</creator><creator>Rabinowitz, Ron</creator><creator>Samueloff, Arnon</creator><creator>Latinsky, Boris</creator><creator>Schimmel, Michael S.</creator><creator>Chen, Ori</creator><creator>Grisaru-Granovsky, Sorina</creator><general>Springer-Verlag</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20130701</creationdate><title>The prenatal diagnosis of isolated fetal varix of the intra-abdominal umbilical vein is associated with favorable neonatal outcome at term: a case series</title><author>Bas-Lando, Maayan ; Rabinowitz, Ron ; Samueloff, Arnon ; Latinsky, Boris ; Schimmel, Michael S. ; Chen, Ori ; Grisaru-Granovsky, Sorina</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-b63cfcd5a2da7229679163695328eeb00c4854fe5aa1c3b0730a843d605c0ad63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Birth Weight</topic><topic>Cesarean Section</topic><topic>Endocrinology</topic><topic>Female</topic><topic>Fetal Diseases - diagnostic imaging</topic><topic>Fetuses</topic><topic>Gestational Age</topic><topic>Gynecology</topic><topic>Health risk assessment</topic><topic>Human Genetics</topic><topic>Humans</topic><topic>Intensive Care, Neonatal</topic><topic>Labor, Induced</topic><topic>Live Birth</topic><topic>Maternal-Fetal Medicine</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Obstetrics/Perinatology/Midwifery</topic><topic>Pregnancy</topic><topic>Premature Birth - etiology</topic><topic>Retrospective Studies</topic><topic>Term Birth</topic><topic>Ultrasonography</topic><topic>Umbilical Veins - abnormalities</topic><topic>Varicose Veins - complications</topic><topic>Varicose Veins - diagnostic imaging</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bas-Lando, Maayan</creatorcontrib><creatorcontrib>Rabinowitz, Ron</creatorcontrib><creatorcontrib>Samueloff, Arnon</creatorcontrib><creatorcontrib>Latinsky, Boris</creatorcontrib><creatorcontrib>Schimmel, Michael S.</creatorcontrib><creatorcontrib>Chen, Ori</creatorcontrib><creatorcontrib>Grisaru-Granovsky, Sorina</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of gynecology and obstetrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bas-Lando, Maayan</au><au>Rabinowitz, Ron</au><au>Samueloff, Arnon</au><au>Latinsky, Boris</au><au>Schimmel, Michael S.</au><au>Chen, Ori</au><au>Grisaru-Granovsky, Sorina</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The prenatal diagnosis of isolated fetal varix of the intra-abdominal umbilical vein is associated with favorable neonatal outcome at term: a case series</atitle><jtitle>Archives of gynecology and obstetrics</jtitle><stitle>Arch Gynecol Obstet</stitle><addtitle>Arch Gynecol Obstet</addtitle><date>2013-07-01</date><risdate>2013</risdate><volume>288</volume><issue>1</issue><spage>33</spage><epage>39</epage><pages>33-39</pages><issn>0932-0067</issn><eissn>1432-0711</eissn><abstract>Objective
Varix of the fetal intra-abdominal umbilical vein (VFIUV) has been reported to be associated with an increased risk of adverse perinatal outcome and especially with intra-uterine fetal demise (IUFD). Induction of preterm birth, as early as 32–34 weeks gestation has been suggested to minimize this risk. We aimed to evaluate our center experience with the antenatal diagnosis of VFIUV and review the relevant literature.
Methods
This is a retrospective case series of all cases (between 2004 and 2009) where the sonographic antenatal diagnosis of VFIUV was registered at any gestational age (GA). Ultrasound, maternal and newborn electronic medical records were used. Descriptive statistics were employed as appropriated and correlation coefficient (
r
) calculated.
Results
We identified 24 women with fetuses, with isolated VFIUV (excluding one lost-to-follow-up). GA at diagnosis was 30.5 ± 4.4 weeks; 13 (56.5 %) cases were diagnosed <32 weeks. The mean VFIUV diameter was 13 ± 2.9 (range 9–20) mm and turbulent flow was reported in 7 cases (30.4 %). GA at birth was 37 ± 2.5 weeks. The small for gestational age rate was 4 % (1/23), while no case of IUFD occurred. The group induction of labor rate was 65.2 %, while 43 % (10/23) due to the diagnosis of VFIUV alone: 17 % (4/23) preterm and 26 % (6/23) at term. The cesarean rate was 17 % (4/23) and NICU admission was required for five neonates (21.7 %). The preterm induction of birth was related to a significantly increased risk for cesarean and neonatal morbidity (
p
= 0.015;
p
= 0.029, respectively). The mode of delivery was not associated with the GA at diagnosis, size/type of flow of VFIUV (
r
= 0.101;
r
= 0.727;
r
= 0.671, respectively) overall (
r
) = 0.4. All fetuses were live-born with normal follow-up at 2–60 months.
Conclusion
Isolated VFIUV has a favorable perinatal outcome at term, unrelated to the structural and flow characteristics of VFIUV. We show that follow-up for growth abnormalities with no preterm induction of birth is a safe maternal and neonatal approach.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>23389248</pmid><doi>10.1007/s00404-013-2743-x</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0932-0067 |
| ispartof | Archives of gynecology and obstetrics, 2013-07, Vol.288 (1), p.33-39 |
| issn | 0932-0067 1432-0711 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1367886049 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Adult Birth Weight Cesarean Section Endocrinology Female Fetal Diseases - diagnostic imaging Fetuses Gestational Age Gynecology Health risk assessment Human Genetics Humans Intensive Care, Neonatal Labor, Induced Live Birth Maternal-Fetal Medicine Medicine Medicine & Public Health Obstetrics/Perinatology/Midwifery Pregnancy Premature Birth - etiology Retrospective Studies Term Birth Ultrasonography Umbilical Veins - abnormalities Varicose Veins - complications Varicose Veins - diagnostic imaging Young Adult |
| title | The prenatal diagnosis of isolated fetal varix of the intra-abdominal umbilical vein is associated with favorable neonatal outcome at term: a case series |
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