Molecular virology of chronic hepatitis B and C: Parallels, contrasts and impact on drug development and treatment outcome

•Curative therapies for chronic hepatitis B and C remain a high unmet medical need.•HBV and HCV have substantial differences that impact antiviral therapy.•Key differences include genome organization, diversity and replication strategy.•HBV can be chronically suppressed with current drugs but “cure”...

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Veröffentlicht in:	Antiviral research 2013-07, Vol.99 (1), p.34-48
1. Verfasser:	Delaney, William E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Antiviral Agents - isolation & purification Antiviral Agents - pharmacology Antiviral therapy Biological and medical sciences Direct-acting antivirals Drug resistance Hepacivirus - drug effects Hepacivirus - physiology Hepatitis B Hepatitis B virus - drug effects Hepatitis B virus - physiology Hepatitis B, Chronic - drug therapy Hepatitis B, Chronic - virology Hepatitis C Hepatitis C, Chronic - drug therapy Hepatitis C, Chronic - virology Human viral diseases Humans Infectious diseases Medical sciences Pharmacology. Drug treatments Viral diseases Viral hepatitis
Online-Zugang:	Volltext
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