Activation of UTP-sensitive P2Y2 receptor induces the expression of cholinergic genes in cultured cortical neurons: a signaling cascade triggered by Ca2+ mobilization and extracellular regulated kinase phosphorylation

ATP functions as an extracellular signaling molecule that is costored and coreleased with neurotransmitters at central and peripheral neuronal synapses. Stimulation by ATP upregulates the expression of synaptic genes in muscle-including the genes for nicotine acetylcholine receptor (α-, δ-, and ε-su...

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Veröffentlicht in:	Molecular pharmacology 2013-07, Vol.84 (1), p.50-61
Hauptverfasser:	Choi, Roy C Y, Chu, Glanice K Y, Siow, Nina L, Yung, Amanda W Y, Yung, Lisa Y, Lee, Pinky S C, Lo, Christopher C W, Simon, Joseph, Dong, Tina T X, Barnard, Eric A, Tsim, Karl W K
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholinesterase - genetics Acetylcholinesterase - metabolism Animals Calcium - metabolism Cells, Cultured Cerebral Cortex - drug effects Cerebral Cortex - metabolism Choline O-Acetyltransferase - genetics Choline O-Acetyltransferase - metabolism Disks Large Homolog 4 Protein Gene Expression - drug effects Gene Expression - genetics GPI-Linked Proteins - genetics GPI-Linked Proteins - metabolism Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism MAP Kinase Signaling System Membrane Proteins - genetics Membrane Proteins - metabolism Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Neurons - drug effects Neurons - metabolism Phosphorylation - drug effects Purinergic P2Y Receptor Agonists - pharmacology Rats Rats, Sprague-Dawley Receptors, Purinergic P2Y1 - genetics Receptors, Purinergic P2Y1 - metabolism Receptors, Purinergic P2Y2 - genetics Receptors, Purinergic P2Y2 - metabolism Signal Transduction - drug effects Uridine Triphosphate - metabolism
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