Nrf2 activators attenuate the progression of nonalcoholic steatohepatitis-related fibrosis in a dietary rat model

Oxidative stress is considered to be a key mechanism of hepatocellular injury and disease progression in patients with nonalcoholic steatohepatitis (NASH). The transcription factor Nrf2 (nuclear factor-erythroid-2-related factor 2) plays a central role in stimulating expression of various antioxidan...

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Veröffentlicht in:	Molecular pharmacology 2013-07, Vol.84 (1), p.62-70
Hauptverfasser:	Shimozono, Rieko, Asaoka, Yoshiji, Yoshizawa, Yoshitaka, Aoki, Takumi, Noda, Hidetoshi, Yamada, Masateru, Kaino, Mie, Mochizuki, Hidenori
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acids - metabolism Animals Anti-Inflammatory Agents - pharmacology Antioxidants - pharmacology Binding Sites - drug effects Binding Sites - genetics Cell Line Choline - metabolism Diet Dihydropyridines - pharmacology Dioxins - pharmacology Disease Progression Down-Regulation - drug effects Down-Regulation - genetics Fatty Liver - genetics Fatty Liver - metabolism Fatty Liver - pathology Fibrosis Gene Expression - drug effects Gene Expression - genetics Humans Hydrogen Peroxide - pharmacology Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism Kelch-Like ECH-Associated Protein 1 Liver - metabolism Male NAD(P)H Dehydrogenase (Quinone) - genetics NAD(P)H Dehydrogenase (Quinone) - metabolism NF-E2-Related Factor 2 - genetics NF-E2-Related Factor 2 - metabolism Non-alcoholic Fatty Liver Disease Oxidative Stress - drug effects Oxidative Stress - genetics Rats Transaminases - blood Up-Regulation - drug effects Up-Regulation - genetics
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