Low-dose human atrial natriuretic peptide for the prevention of postoperative cardiopulmonary complications in chronic obstructive pulmonary disease patients undergoing lung cancer surgery
OBJECTIVES Lung cancer patients with chronic obstructive pulmonary disease are at an increased risk of respiratory and cardiovascular complications after pulmonary resection. The objective of the present study was to evaluate the clinical effects of low-dose human atrial natriuretic peptide (hANP) o...
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| Veröffentlicht in: | European journal of cardio-thoracic surgery 2013-07, Vol.44 (1), p.98-103 |
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| container_title | European journal of cardio-thoracic surgery |
| container_volume | 44 |
| creator | Nojiri, Takashi Inoue, Masayoshi Maeda, Hajime Takeuchi, Yukiyasu Sawabata, Noriyoshi Shintani, Yasushi Yamamoto, Kazuhiro Okumura, Meinoshin |
| description | OBJECTIVES
Lung cancer patients with chronic obstructive pulmonary disease are at an increased risk of respiratory and cardiovascular complications after pulmonary resection. The objective of the present study was to evaluate the clinical effects of low-dose human atrial natriuretic peptide (hANP) on postoperative cardiopulmonary complications in untreated chronic obstructive pulmonary disease patients undergoing lung cancer surgery.
METHODS
Of 824 patients who underwent an elective pulmonary resection procedure for lung cancer in two specialized thoracic centres between 2008 and 2011, 202 consecutive patients who had airflow limitation before surgery were included in this retrospective study. The results were compared between patients who did and those who did not receive hANP during the perioperative period. The primary endpoint was the incidence of postoperative cardiopulmonary complications. Postoperative haemodynamics, white blood cell (WBC) counts and C-reactive protein (CRP) levels were also examined. Furthermore, propensity score matching analysis was used to reduce treatment selection bias from patient characteristics.
RESULTS
The incidence of postoperative cardiopulmonary complications was significantly lower in the hANP group than in the control group (14 vs 36%, P < 0.01). The propensity score matching analysis confirmed the significantly decreased frequency of postoperative cardiopulmonary complications in the hANP group. Patients in the hANP group showed significantly lower WBC counts and serum CRP levels postoperatively.
CONCLUSIONS
Treatment with hANP during the perioperative period had a prophylactic effect against postoperative cardiopulmonary complications in chronic obstructive pulmonary disease patients undergoing lung cancer surgery.
Trial registration number
JPRN-UMIN000003631. |
| doi_str_mv | 10.1093/ejcts/ezs646 |
| format | Article |
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Lung cancer patients with chronic obstructive pulmonary disease are at an increased risk of respiratory and cardiovascular complications after pulmonary resection. The objective of the present study was to evaluate the clinical effects of low-dose human atrial natriuretic peptide (hANP) on postoperative cardiopulmonary complications in untreated chronic obstructive pulmonary disease patients undergoing lung cancer surgery.
METHODS
Of 824 patients who underwent an elective pulmonary resection procedure for lung cancer in two specialized thoracic centres between 2008 and 2011, 202 consecutive patients who had airflow limitation before surgery were included in this retrospective study. The results were compared between patients who did and those who did not receive hANP during the perioperative period. The primary endpoint was the incidence of postoperative cardiopulmonary complications. Postoperative haemodynamics, white blood cell (WBC) counts and C-reactive protein (CRP) levels were also examined. Furthermore, propensity score matching analysis was used to reduce treatment selection bias from patient characteristics.
RESULTS
The incidence of postoperative cardiopulmonary complications was significantly lower in the hANP group than in the control group (14 vs 36%, P < 0.01). The propensity score matching analysis confirmed the significantly decreased frequency of postoperative cardiopulmonary complications in the hANP group. Patients in the hANP group showed significantly lower WBC counts and serum CRP levels postoperatively.
CONCLUSIONS
Treatment with hANP during the perioperative period had a prophylactic effect against postoperative cardiopulmonary complications in chronic obstructive pulmonary disease patients undergoing lung cancer surgery.
Trial registration number
JPRN-UMIN000003631.</description><identifier>ISSN: 1010-7940</identifier><identifier>EISSN: 1873-734X</identifier><identifier>DOI: 10.1093/ejcts/ezs646</identifier><identifier>PMID: 23242980</identifier><language>eng</language><publisher>Germany: Oxford University Press</publisher><subject>Aged ; Aged, 80 and over ; Atrial Natriuretic Factor - administration & dosage ; Atrial Natriuretic Factor - therapeutic use ; Blood Pressure ; C-Reactive Protein ; Cardiotonic Agents - administration & dosage ; Cardiotonic Agents - therapeutic use ; Female ; Heart Rate ; Humans ; Leukocyte Count ; Lung Neoplasms - complications ; Lung Neoplasms - epidemiology ; Lung Neoplasms - mortality ; Lung Neoplasms - surgery ; Male ; Middle Aged ; Perioperative Care - methods ; Postoperative Complications - drug therapy ; Postoperative Complications - prevention & control ; Propensity Score ; Pulmonary Disease, Chronic Obstructive - complications ; Pulmonary Disease, Chronic Obstructive - epidemiology</subject><ispartof>European journal of cardio-thoracic surgery, 2013-07, Vol.44 (1), p.98-103</ispartof><rights>The Author 2012. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved. 2012</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1578,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23242980$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nojiri, Takashi</creatorcontrib><creatorcontrib>Inoue, Masayoshi</creatorcontrib><creatorcontrib>Maeda, Hajime</creatorcontrib><creatorcontrib>Takeuchi, Yukiyasu</creatorcontrib><creatorcontrib>Sawabata, Noriyoshi</creatorcontrib><creatorcontrib>Shintani, Yasushi</creatorcontrib><creatorcontrib>Yamamoto, Kazuhiro</creatorcontrib><creatorcontrib>Okumura, Meinoshin</creatorcontrib><title>Low-dose human atrial natriuretic peptide for the prevention of postoperative cardiopulmonary complications in chronic obstructive pulmonary disease patients undergoing lung cancer surgery</title><title>European journal of cardio-thoracic surgery</title><addtitle>Eur J Cardiothorac Surg</addtitle><description>OBJECTIVES
Lung cancer patients with chronic obstructive pulmonary disease are at an increased risk of respiratory and cardiovascular complications after pulmonary resection. The objective of the present study was to evaluate the clinical effects of low-dose human atrial natriuretic peptide (hANP) on postoperative cardiopulmonary complications in untreated chronic obstructive pulmonary disease patients undergoing lung cancer surgery.
METHODS
Of 824 patients who underwent an elective pulmonary resection procedure for lung cancer in two specialized thoracic centres between 2008 and 2011, 202 consecutive patients who had airflow limitation before surgery were included in this retrospective study. The results were compared between patients who did and those who did not receive hANP during the perioperative period. The primary endpoint was the incidence of postoperative cardiopulmonary complications. Postoperative haemodynamics, white blood cell (WBC) counts and C-reactive protein (CRP) levels were also examined. Furthermore, propensity score matching analysis was used to reduce treatment selection bias from patient characteristics.
RESULTS
The incidence of postoperative cardiopulmonary complications was significantly lower in the hANP group than in the control group (14 vs 36%, P < 0.01). The propensity score matching analysis confirmed the significantly decreased frequency of postoperative cardiopulmonary complications in the hANP group. Patients in the hANP group showed significantly lower WBC counts and serum CRP levels postoperatively.
CONCLUSIONS
Treatment with hANP during the perioperative period had a prophylactic effect against postoperative cardiopulmonary complications in chronic obstructive pulmonary disease patients undergoing lung cancer surgery.
Trial registration number
JPRN-UMIN000003631.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Atrial Natriuretic Factor - administration & dosage</subject><subject>Atrial Natriuretic Factor - therapeutic use</subject><subject>Blood Pressure</subject><subject>C-Reactive Protein</subject><subject>Cardiotonic Agents - administration & dosage</subject><subject>Cardiotonic Agents - therapeutic use</subject><subject>Female</subject><subject>Heart Rate</subject><subject>Humans</subject><subject>Leukocyte Count</subject><subject>Lung Neoplasms - complications</subject><subject>Lung Neoplasms - epidemiology</subject><subject>Lung Neoplasms - mortality</subject><subject>Lung Neoplasms - surgery</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Perioperative Care - methods</subject><subject>Postoperative Complications - drug therapy</subject><subject>Postoperative Complications - prevention & control</subject><subject>Propensity Score</subject><subject>Pulmonary Disease, Chronic Obstructive - complications</subject><subject>Pulmonary Disease, Chronic Obstructive - epidemiology</subject><issn>1010-7940</issn><issn>1873-734X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkctu1DAUhi0EohfYsa68g01a2yeTOMuqgrbSSGxAYhc59pkZV4nt-lJUnq0Ph6fTwuZc5O_8x_ZPyCfOzjkb4ALvdE4X-Cd1bfeGHHPZQ9ND--ttrRlnTT-07IicpHTHGOtA9O_JkQDRikGyY_K09r8b4xPSXVmUoypHq2bq9rlEzFbTgCFbg3TjI807pCHiA7psvaN-Q4NP2QeMKtsHpFpFY30o8-Kdio9U-yXMVqs9nah1VO-id1XUTynHop-H_uPGJlT1LqEO1BWJFmcwbr11WzqXGrRyGiNNJW4xPn4g7zZqTvjxJZ-Sn9--_ri6adbfr2-vLteNFy3kRgAMSopBMd1NqxWbUIpOC825WHW9FDANUg49qEl2RjAYNgJag7xj0tTewCn5ctAN0d8XTHlcbNI4z8qhL2nkUGUkAOsrevaClmlBM4Zol_qy8fXHK_D5APgS_p1yNu69HJ-9HA9ewl9GipdY</recordid><startdate>201307</startdate><enddate>201307</enddate><creator>Nojiri, Takashi</creator><creator>Inoue, Masayoshi</creator><creator>Maeda, Hajime</creator><creator>Takeuchi, Yukiyasu</creator><creator>Sawabata, Noriyoshi</creator><creator>Shintani, Yasushi</creator><creator>Yamamoto, Kazuhiro</creator><creator>Okumura, Meinoshin</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>201307</creationdate><title>Low-dose human atrial natriuretic peptide for the prevention of postoperative cardiopulmonary complications in chronic obstructive pulmonary disease patients undergoing lung cancer surgery</title><author>Nojiri, Takashi ; Inoue, Masayoshi ; Maeda, Hajime ; Takeuchi, Yukiyasu ; Sawabata, Noriyoshi ; Shintani, Yasushi ; Yamamoto, Kazuhiro ; Okumura, Meinoshin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-o243t-2339a829a0c6b550be826c2c112567823b988973ab86d2039f234de1608dd20d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Atrial Natriuretic Factor - administration & dosage</topic><topic>Atrial Natriuretic Factor - therapeutic use</topic><topic>Blood Pressure</topic><topic>C-Reactive Protein</topic><topic>Cardiotonic Agents - administration & dosage</topic><topic>Cardiotonic Agents - therapeutic use</topic><topic>Female</topic><topic>Heart Rate</topic><topic>Humans</topic><topic>Leukocyte Count</topic><topic>Lung Neoplasms - complications</topic><topic>Lung Neoplasms - epidemiology</topic><topic>Lung Neoplasms - mortality</topic><topic>Lung Neoplasms - surgery</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Perioperative Care - methods</topic><topic>Postoperative Complications - drug therapy</topic><topic>Postoperative Complications - prevention & control</topic><topic>Propensity Score</topic><topic>Pulmonary Disease, Chronic Obstructive - complications</topic><topic>Pulmonary Disease, Chronic Obstructive - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nojiri, Takashi</creatorcontrib><creatorcontrib>Inoue, Masayoshi</creatorcontrib><creatorcontrib>Maeda, Hajime</creatorcontrib><creatorcontrib>Takeuchi, Yukiyasu</creatorcontrib><creatorcontrib>Sawabata, Noriyoshi</creatorcontrib><creatorcontrib>Shintani, Yasushi</creatorcontrib><creatorcontrib>Yamamoto, Kazuhiro</creatorcontrib><creatorcontrib>Okumura, Meinoshin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of cardio-thoracic surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nojiri, Takashi</au><au>Inoue, Masayoshi</au><au>Maeda, Hajime</au><au>Takeuchi, Yukiyasu</au><au>Sawabata, Noriyoshi</au><au>Shintani, Yasushi</au><au>Yamamoto, Kazuhiro</au><au>Okumura, Meinoshin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Low-dose human atrial natriuretic peptide for the prevention of postoperative cardiopulmonary complications in chronic obstructive pulmonary disease patients undergoing lung cancer surgery</atitle><jtitle>European journal of cardio-thoracic surgery</jtitle><addtitle>Eur J Cardiothorac Surg</addtitle><date>2013-07</date><risdate>2013</risdate><volume>44</volume><issue>1</issue><spage>98</spage><epage>103</epage><pages>98-103</pages><issn>1010-7940</issn><eissn>1873-734X</eissn><abstract>OBJECTIVES
Lung cancer patients with chronic obstructive pulmonary disease are at an increased risk of respiratory and cardiovascular complications after pulmonary resection. The objective of the present study was to evaluate the clinical effects of low-dose human atrial natriuretic peptide (hANP) on postoperative cardiopulmonary complications in untreated chronic obstructive pulmonary disease patients undergoing lung cancer surgery.
METHODS
Of 824 patients who underwent an elective pulmonary resection procedure for lung cancer in two specialized thoracic centres between 2008 and 2011, 202 consecutive patients who had airflow limitation before surgery were included in this retrospective study. The results were compared between patients who did and those who did not receive hANP during the perioperative period. The primary endpoint was the incidence of postoperative cardiopulmonary complications. Postoperative haemodynamics, white blood cell (WBC) counts and C-reactive protein (CRP) levels were also examined. Furthermore, propensity score matching analysis was used to reduce treatment selection bias from patient characteristics.
RESULTS
The incidence of postoperative cardiopulmonary complications was significantly lower in the hANP group than in the control group (14 vs 36%, P < 0.01). The propensity score matching analysis confirmed the significantly decreased frequency of postoperative cardiopulmonary complications in the hANP group. Patients in the hANP group showed significantly lower WBC counts and serum CRP levels postoperatively.
CONCLUSIONS
Treatment with hANP during the perioperative period had a prophylactic effect against postoperative cardiopulmonary complications in chronic obstructive pulmonary disease patients undergoing lung cancer surgery.
Trial registration number
JPRN-UMIN000003631.</abstract><cop>Germany</cop><pub>Oxford University Press</pub><pmid>23242980</pmid><doi>10.1093/ejcts/ezs646</doi><tpages>6</tpages></addata></record> |
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| ispartof | European journal of cardio-thoracic surgery, 2013-07, Vol.44 (1), p.98-103 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | Aged Aged, 80 and over Atrial Natriuretic Factor - administration & dosage Atrial Natriuretic Factor - therapeutic use Blood Pressure C-Reactive Protein Cardiotonic Agents - administration & dosage Cardiotonic Agents - therapeutic use Female Heart Rate Humans Leukocyte Count Lung Neoplasms - complications Lung Neoplasms - epidemiology Lung Neoplasms - mortality Lung Neoplasms - surgery Male Middle Aged Perioperative Care - methods Postoperative Complications - drug therapy Postoperative Complications - prevention & control Propensity Score Pulmonary Disease, Chronic Obstructive - complications Pulmonary Disease, Chronic Obstructive - epidemiology |
| title | Low-dose human atrial natriuretic peptide for the prevention of postoperative cardiopulmonary complications in chronic obstructive pulmonary disease patients undergoing lung cancer surgery |
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