Synthesis and cytotoxic activity on human cancer cells of carbamate derivatives of 4β-(1,2,3-triazol-1-yl)podophyllotoxin

Carbamate derivatives of 4β-(1,2,3-triazol-1-yl)podophyllotoxin were synthesized by means of click chemistry, and their cytotoxicities against human cancer cell lines HL-60, A-549, HeLa, and HCT-8 were evaluated. Some compounds were more potent than the anticancer drug etoposide. 4′-O-Demethyl-4β-[(...

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Veröffentlicht in:	European journal of medicinal chemistry 2013-06, Vol.64, p.621-628
Hauptverfasser:	Liu, Jian-Fei, Sang, Chun-Yan, Xu, Xiao-Hui, Zhang, Lin-Lin, Yang, Xuan, Hui, Lin, Zhang, Jin-Bang, Chen, Shi-Wu
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Apoptosis - drug effects Carbamates - chemical synthesis Carbamates - chemistry Carbamates - pharmacology Cell Cycle - drug effects Cell Line, Tumor Cell Proliferation - drug effects Dose-Response Relationship, Drug Drug Screening Assays, Antitumor HeLa Cells HL-60 Cells Humans Microtubules Molecular Structure Podophyllotoxin Podophyllotoxin - analogs & derivatives Podophyllotoxin - chemistry Podophyllotoxin - pharmacology Structure-Activity Relationship Topoisomerase-II Triazole
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