Pulmonary resections following prior definitive chemoradiation therapy are associated with acceptable survival
OBJECTIVES The benefits of salvage resection for lung cancer recurrence following high-dose curative-intent chemoradiation therapy are unclear. We assessed survival after salvage lung resection following definitive chemoradiation. METHODS Medical records of patients undergoing lung cancer resections...
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| Veröffentlicht in: | European journal of cardio-thoracic surgery 2013-07, Vol.44 (1), p.e66-e70 |
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| container_title | European journal of cardio-thoracic surgery |
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| creator | Kuzmik, Gregory A. Detterbeck, Frank C. Decker, Roy H. Boffa, Daniel J. Wang, Zuoheng Oliva, Isabel B. Kim, Anthony W. |
| description | OBJECTIVES
The benefits of salvage resection for lung cancer recurrence following high-dose curative-intent chemoradiation therapy are unclear. We assessed survival after salvage lung resection following definitive chemoradiation.
METHODS
Medical records of patients undergoing lung cancer resections at our institution following definitive chemoradiation therapy were reviewed from June 2006 to August 2012. A multivariate Cox proportional model was used to assess the factors associated with improved survival.
RESULTS
Fourteen patients had chemoradiation therapy before lung resection (pneumonectomy, lobectomy or segmentectomy). Pretherapy cancer stage was Stage III in 11 patients, Stage IV in 2 and Stage II in 1. Postoperative 2-year survival was 49%. Patients had a median disease-free interval before resection of 33 months. No variables were found to be associated with improved post-chemoradiation survival from the time of definitive treatment or postoperative survival. Complications occurred in 6 (43%) patients, with 2 of those complications directly attributable to post-chemoradiation changes. There were no perioperative deaths within 90 days.
CONCLUSIONS
Salvage lung resection for recurrent lung cancer following definitive chemoradiation therapy is feasible and is associated with postoperative survival and complication rates that are reasonable. |
| doi_str_mv | 10.1093/ejcts/ezt184 |
| format | Article |
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The benefits of salvage resection for lung cancer recurrence following high-dose curative-intent chemoradiation therapy are unclear. We assessed survival after salvage lung resection following definitive chemoradiation.
METHODS
Medical records of patients undergoing lung cancer resections at our institution following definitive chemoradiation therapy were reviewed from June 2006 to August 2012. A multivariate Cox proportional model was used to assess the factors associated with improved survival.
RESULTS
Fourteen patients had chemoradiation therapy before lung resection (pneumonectomy, lobectomy or segmentectomy). Pretherapy cancer stage was Stage III in 11 patients, Stage IV in 2 and Stage II in 1. Postoperative 2-year survival was 49%. Patients had a median disease-free interval before resection of 33 months. No variables were found to be associated with improved post-chemoradiation survival from the time of definitive treatment or postoperative survival. Complications occurred in 6 (43%) patients, with 2 of those complications directly attributable to post-chemoradiation changes. There were no perioperative deaths within 90 days.
CONCLUSIONS
Salvage lung resection for recurrent lung cancer following definitive chemoradiation therapy is feasible and is associated with postoperative survival and complication rates that are reasonable.</description><identifier>ISSN: 1010-7940</identifier><identifier>EISSN: 1873-734X</identifier><identifier>DOI: 10.1093/ejcts/ezt184</identifier><identifier>PMID: 23557918</identifier><language>eng</language><publisher>Germany: Oxford University Press</publisher><subject>Aged ; Chemoradiotherapy ; Female ; Humans ; Lung Neoplasms - epidemiology ; Lung Neoplasms - mortality ; Lung Neoplasms - therapy ; Male ; Middle Aged ; Pneumonectomy ; Postoperative Complications ; Retrospective Studies ; Salvage Therapy - methods ; Survival Analysis</subject><ispartof>European journal of cardio-thoracic surgery, 2013-07, Vol.44 (1), p.e66-e70</ispartof><rights>The Author 2013. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved. 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c361t-2fe3eccf3eaac608fba2467473ac410d1cd12b02c58105528f020ed971d663933</citedby><cites>FETCH-LOGICAL-c361t-2fe3eccf3eaac608fba2467473ac410d1cd12b02c58105528f020ed971d663933</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,1585,27926,27927</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23557918$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kuzmik, Gregory A.</creatorcontrib><creatorcontrib>Detterbeck, Frank C.</creatorcontrib><creatorcontrib>Decker, Roy H.</creatorcontrib><creatorcontrib>Boffa, Daniel J.</creatorcontrib><creatorcontrib>Wang, Zuoheng</creatorcontrib><creatorcontrib>Oliva, Isabel B.</creatorcontrib><creatorcontrib>Kim, Anthony W.</creatorcontrib><title>Pulmonary resections following prior definitive chemoradiation therapy are associated with acceptable survival</title><title>European journal of cardio-thoracic surgery</title><addtitle>Eur J Cardiothorac Surg</addtitle><description>OBJECTIVES
The benefits of salvage resection for lung cancer recurrence following high-dose curative-intent chemoradiation therapy are unclear. We assessed survival after salvage lung resection following definitive chemoradiation.
METHODS
Medical records of patients undergoing lung cancer resections at our institution following definitive chemoradiation therapy were reviewed from June 2006 to August 2012. A multivariate Cox proportional model was used to assess the factors associated with improved survival.
RESULTS
Fourteen patients had chemoradiation therapy before lung resection (pneumonectomy, lobectomy or segmentectomy). Pretherapy cancer stage was Stage III in 11 patients, Stage IV in 2 and Stage II in 1. Postoperative 2-year survival was 49%. Patients had a median disease-free interval before resection of 33 months. No variables were found to be associated with improved post-chemoradiation survival from the time of definitive treatment or postoperative survival. Complications occurred in 6 (43%) patients, with 2 of those complications directly attributable to post-chemoradiation changes. There were no perioperative deaths within 90 days.
CONCLUSIONS
Salvage lung resection for recurrent lung cancer following definitive chemoradiation therapy is feasible and is associated with postoperative survival and complication rates that are reasonable.</description><subject>Aged</subject><subject>Chemoradiotherapy</subject><subject>Female</subject><subject>Humans</subject><subject>Lung Neoplasms - epidemiology</subject><subject>Lung Neoplasms - mortality</subject><subject>Lung Neoplasms - therapy</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Pneumonectomy</subject><subject>Postoperative Complications</subject><subject>Retrospective Studies</subject><subject>Salvage Therapy - methods</subject><subject>Survival Analysis</subject><issn>1010-7940</issn><issn>1873-734X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kD1PwzAQQC0EoqWwMSNvMBDqjyR2RlTxJVWCASS2yHUu1FUSB9tpVX49KSmMTHc6PT3pHkLnlNxQkvEprHTwU_gKVMYHaEyl4JHg8fthvxNKIpHFZIROvF8RQlLOxDEaMZ4kIqNyjJqXrqpto9wWO_Cgg7GNx6WtKrsxzQdunbEOF1CaxgSzBqyXUFunCqN2KA5LcKrdYuUAK--t7u9Q4I0JS6y0hjaoRQXYd25t1qo6RUelqjyc7ecEvd3fvc4eo_nzw9Psdh5pntIQsRI4aF1yUEqnRJYLxeJUxIIrHVNSUF1QtiBMJ5KSJGGyJIxAkQlapCnPOJ-gq8HbOvvZgQ95bbyGqlIN2M7nlKdCSibTpEevB1Q7672DMu9_rvsgOSX5rnD-UzgfCvf4xd7cLWoo_uDfpD1wOQC2a_9XfQPK1YmU</recordid><startdate>201307</startdate><enddate>201307</enddate><creator>Kuzmik, Gregory A.</creator><creator>Detterbeck, Frank C.</creator><creator>Decker, Roy H.</creator><creator>Boffa, Daniel J.</creator><creator>Wang, Zuoheng</creator><creator>Oliva, Isabel B.</creator><creator>Kim, Anthony W.</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201307</creationdate><title>Pulmonary resections following prior definitive chemoradiation therapy are associated with acceptable survival</title><author>Kuzmik, Gregory A. ; Detterbeck, Frank C. ; Decker, Roy H. ; Boffa, Daniel J. ; Wang, Zuoheng ; Oliva, Isabel B. ; Kim, Anthony W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c361t-2fe3eccf3eaac608fba2467473ac410d1cd12b02c58105528f020ed971d663933</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Aged</topic><topic>Chemoradiotherapy</topic><topic>Female</topic><topic>Humans</topic><topic>Lung Neoplasms - epidemiology</topic><topic>Lung Neoplasms - mortality</topic><topic>Lung Neoplasms - therapy</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Pneumonectomy</topic><topic>Postoperative Complications</topic><topic>Retrospective Studies</topic><topic>Salvage Therapy - methods</topic><topic>Survival Analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kuzmik, Gregory A.</creatorcontrib><creatorcontrib>Detterbeck, Frank C.</creatorcontrib><creatorcontrib>Decker, Roy H.</creatorcontrib><creatorcontrib>Boffa, Daniel J.</creatorcontrib><creatorcontrib>Wang, Zuoheng</creatorcontrib><creatorcontrib>Oliva, Isabel B.</creatorcontrib><creatorcontrib>Kim, Anthony W.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of cardio-thoracic surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kuzmik, Gregory A.</au><au>Detterbeck, Frank C.</au><au>Decker, Roy H.</au><au>Boffa, Daniel J.</au><au>Wang, Zuoheng</au><au>Oliva, Isabel B.</au><au>Kim, Anthony W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pulmonary resections following prior definitive chemoradiation therapy are associated with acceptable survival</atitle><jtitle>European journal of cardio-thoracic surgery</jtitle><addtitle>Eur J Cardiothorac Surg</addtitle><date>2013-07</date><risdate>2013</risdate><volume>44</volume><issue>1</issue><spage>e66</spage><epage>e70</epage><pages>e66-e70</pages><issn>1010-7940</issn><eissn>1873-734X</eissn><abstract>OBJECTIVES
The benefits of salvage resection for lung cancer recurrence following high-dose curative-intent chemoradiation therapy are unclear. We assessed survival after salvage lung resection following definitive chemoradiation.
METHODS
Medical records of patients undergoing lung cancer resections at our institution following definitive chemoradiation therapy were reviewed from June 2006 to August 2012. A multivariate Cox proportional model was used to assess the factors associated with improved survival.
RESULTS
Fourteen patients had chemoradiation therapy before lung resection (pneumonectomy, lobectomy or segmentectomy). Pretherapy cancer stage was Stage III in 11 patients, Stage IV in 2 and Stage II in 1. Postoperative 2-year survival was 49%. Patients had a median disease-free interval before resection of 33 months. No variables were found to be associated with improved post-chemoradiation survival from the time of definitive treatment or postoperative survival. Complications occurred in 6 (43%) patients, with 2 of those complications directly attributable to post-chemoradiation changes. There were no perioperative deaths within 90 days.
CONCLUSIONS
Salvage lung resection for recurrent lung cancer following definitive chemoradiation therapy is feasible and is associated with postoperative survival and complication rates that are reasonable.</abstract><cop>Germany</cop><pub>Oxford University Press</pub><pmid>23557918</pmid><doi>10.1093/ejcts/ezt184</doi><oa>free_for_read</oa></addata></record> |
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| ispartof | European journal of cardio-thoracic surgery, 2013-07, Vol.44 (1), p.e66-e70 |
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| source | MEDLINE; Oxford Journals Online; Alma/SFX Local Collection; EZB Electronic Journals Library |
| subjects | Aged Chemoradiotherapy Female Humans Lung Neoplasms - epidemiology Lung Neoplasms - mortality Lung Neoplasms - therapy Male Middle Aged Pneumonectomy Postoperative Complications Retrospective Studies Salvage Therapy - methods Survival Analysis |
| title | Pulmonary resections following prior definitive chemoradiation therapy are associated with acceptable survival |
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