Determinants of Progression of Aortic Stiffness in Hemodialysis Patients: A Prospective Longitudinal Study
Aortic stiffness is associated with increased cardiovascular mortality in patients with chronic kidney disease. However, the rate of progression of arterial stiffness and the role of cardiovascular risk factors in the progression of arterial stiffness has never been established in a longitudinal stu...
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| Veröffentlicht in: | Hypertension (Dallas, Tex. 1979) Tex. 1979), 2013-07, Vol.62 (1), p.154-160 |
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| creator | Utescu, Mihai S Couture, Véronique Mac-Way, Fabrice De Serres, Sacha A Marquis, Karine Larivière, Richard Desmeules, Simon Lebel, Marcel Boutouyrie, Pierre Agharazii, Mohsen |
| description | Aortic stiffness is associated with increased cardiovascular mortality in patients with chronic kidney disease. However, the rate of progression of arterial stiffness and the role of cardiovascular risk factors in the progression of arterial stiffness has never been established in a longitudinal study. In a prospective, longitudinal, observational study, carotid-femoral pulse wave velocity and carotid-radial pulse wave velocity were assessed in 109 hemodialysis patients at baseline and after a mean follow-up of 1.2 years. We examined the impact of age, atherosclerotic cardiovascular disease, diabetes mellitus, dialysis vintage, and pentosidine (a well-characterized, advanced glycation end products) on the rate of progression of aortic stiffness. The annual rate of changes in carotid-femoral pulse wave velocity and carotid-radial pulse wave velocity were 0.84 m/s per year (95% confidence interval, 0.50–1.12 m/s per year) and −0.66 m/s per year (95% confidence interval, −0.85 to −0.47 m/s per year), respectively. Older subjects, and patients with diabetes mellitus or atherosclerotic cardiovascular disease had higher aortic stiffness at baseline, however, the rate of progression of aortic stiffness was only determined by plasma pentosidine levels (P=0.001). The degree of baseline aortic stiffness was a significant determinant of the regression of brachial stiffness (P |
| doi_str_mv | 10.1161/HYPERTENSIONAHA.113.01200 |
| format | Article |
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However, the rate of progression of arterial stiffness and the role of cardiovascular risk factors in the progression of arterial stiffness has never been established in a longitudinal study. In a prospective, longitudinal, observational study, carotid-femoral pulse wave velocity and carotid-radial pulse wave velocity were assessed in 109 hemodialysis patients at baseline and after a mean follow-up of 1.2 years. We examined the impact of age, atherosclerotic cardiovascular disease, diabetes mellitus, dialysis vintage, and pentosidine (a well-characterized, advanced glycation end products) on the rate of progression of aortic stiffness. The annual rate of changes in carotid-femoral pulse wave velocity and carotid-radial pulse wave velocity were 0.84 m/s per year (95% confidence interval, 0.50–1.12 m/s per year) and −0.66 m/s per year (95% confidence interval, −0.85 to −0.47 m/s per year), respectively. Older subjects, and patients with diabetes mellitus or atherosclerotic cardiovascular disease had higher aortic stiffness at baseline, however, the rate of progression of aortic stiffness was only determined by plasma pentosidine levels (P=0.001). The degree of baseline aortic stiffness was a significant determinant of the regression of brachial stiffness (P<0.001) suggesting that the regression of brachial stiffness occurs in response to central aortic stiffness. These findings suggest that traditional cardiovascular risk factors may play some role in the progression of aortic stiffness before development of advanced chronic kidney disease, and that the enhanced rate of progression of aortic stiffness in chronic kidney disease patients on dialysis are probably determined by more specific chronic kidney disease–related risk factors such as advanced-glycation end products.</description><identifier>ISSN: 0194-911X</identifier><identifier>EISSN: 1524-4563</identifier><identifier>DOI: 10.1161/HYPERTENSIONAHA.113.01200</identifier><identifier>PMID: 23648699</identifier><identifier>CODEN: HPRTDN</identifier><language>eng</language><publisher>Hagerstown, MD: American Heart Association, Inc</publisher><subject>Aged ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Arterial hypertension. Arterial hypotension ; Biological and medical sciences ; Blood and lymphatic vessels ; Cardiology. Vascular system ; Cardiovascular Diseases - epidemiology ; Cardiovascular Diseases - etiology ; Cardiovascular Diseases - physiopathology ; Disease Progression ; Emergency and intensive care: renal failure. Dialysis management ; Female ; Follow-Up Studies ; Humans ; Incidence ; Intensive care medicine ; Kidney Failure, Chronic - therapy ; Kidneys ; Male ; Medical sciences ; Middle Aged ; Nephrology. Urinary tract diseases ; Nephropathies. Renovascular diseases. Renal failure ; Prospective Studies ; Quebec - epidemiology ; Renal Dialysis - adverse effects ; Renal failure ; Risk Factors ; Survival Rate - trends ; Urinary system involvement in other diseases. Miscellaneous ; Vascular Stiffness</subject><ispartof>Hypertension (Dallas, Tex. 1979), 2013-07, Vol.62 (1), p.154-160</ispartof><rights>2013 American Heart Association, Inc.</rights><rights>2014 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4010-3470c036c3cb8c435d5e3bbdd19ec42951e635fc5fe54d0da2eac6af44141be3</citedby><cites>FETCH-LOGICAL-c4010-3470c036c3cb8c435d5e3bbdd19ec42951e635fc5fe54d0da2eac6af44141be3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3674,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27480269$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23648699$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Utescu, Mihai S</creatorcontrib><creatorcontrib>Couture, Véronique</creatorcontrib><creatorcontrib>Mac-Way, Fabrice</creatorcontrib><creatorcontrib>De Serres, Sacha A</creatorcontrib><creatorcontrib>Marquis, Karine</creatorcontrib><creatorcontrib>Larivière, Richard</creatorcontrib><creatorcontrib>Desmeules, Simon</creatorcontrib><creatorcontrib>Lebel, Marcel</creatorcontrib><creatorcontrib>Boutouyrie, Pierre</creatorcontrib><creatorcontrib>Agharazii, Mohsen</creatorcontrib><title>Determinants of Progression of Aortic Stiffness in Hemodialysis Patients: A Prospective Longitudinal Study</title><title>Hypertension (Dallas, Tex. 1979)</title><addtitle>Hypertension</addtitle><description>Aortic stiffness is associated with increased cardiovascular mortality in patients with chronic kidney disease. However, the rate of progression of arterial stiffness and the role of cardiovascular risk factors in the progression of arterial stiffness has never been established in a longitudinal study. In a prospective, longitudinal, observational study, carotid-femoral pulse wave velocity and carotid-radial pulse wave velocity were assessed in 109 hemodialysis patients at baseline and after a mean follow-up of 1.2 years. We examined the impact of age, atherosclerotic cardiovascular disease, diabetes mellitus, dialysis vintage, and pentosidine (a well-characterized, advanced glycation end products) on the rate of progression of aortic stiffness. The annual rate of changes in carotid-femoral pulse wave velocity and carotid-radial pulse wave velocity were 0.84 m/s per year (95% confidence interval, 0.50–1.12 m/s per year) and −0.66 m/s per year (95% confidence interval, −0.85 to −0.47 m/s per year), respectively. Older subjects, and patients with diabetes mellitus or atherosclerotic cardiovascular disease had higher aortic stiffness at baseline, however, the rate of progression of aortic stiffness was only determined by plasma pentosidine levels (P=0.001). The degree of baseline aortic stiffness was a significant determinant of the regression of brachial stiffness (P<0.001) suggesting that the regression of brachial stiffness occurs in response to central aortic stiffness. These findings suggest that traditional cardiovascular risk factors may play some role in the progression of aortic stiffness before development of advanced chronic kidney disease, and that the enhanced rate of progression of aortic stiffness in chronic kidney disease patients on dialysis are probably determined by more specific chronic kidney disease–related risk factors such as advanced-glycation end products.</description><subject>Aged</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Arterial hypertension. Arterial hypotension</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Cardiology. Vascular system</subject><subject>Cardiovascular Diseases - epidemiology</subject><subject>Cardiovascular Diseases - etiology</subject><subject>Cardiovascular Diseases - physiopathology</subject><subject>Disease Progression</subject><subject>Emergency and intensive care: renal failure. Dialysis management</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Incidence</subject><subject>Intensive care medicine</subject><subject>Kidney Failure, Chronic - therapy</subject><subject>Kidneys</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Nephropathies. Renovascular diseases. Renal failure</subject><subject>Prospective Studies</subject><subject>Quebec - epidemiology</subject><subject>Renal Dialysis - adverse effects</subject><subject>Renal failure</subject><subject>Risk Factors</subject><subject>Survival Rate - trends</subject><subject>Urinary system involvement in other diseases. Miscellaneous</subject><subject>Vascular Stiffness</subject><issn>0194-911X</issn><issn>1524-4563</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUFP2zAYhi00NArbX0DZYdIuYXbsuMmkHSJWKFIF1ehhnCLH_gxmTtzZzlD_Pe5amLTTTpZfPc_nT68R-kDwGSGcfJ7fLWffV7Pr26ub62bepJCeYVJgfIAmpCxYzkpO36AJJjXLa0J-HKHjEB4xJoyx6Vt0VFDOKl7XE_T4DSL43gxiiCFzOlt6d-8hBOOG7bVxPhqZ3Uaj9ZDizAzZHHqnjLCbYEK2FNFAcr9kzdYNa5DR_IZs4YZ7E0eVJtukj2rzDh1qYQO8358naHUxW53P88XN5dV5s8glwwTnlE2xxJRLKrtKMlqqEmjXKUVqkKyoSwKcllqWGkqmsBIFCMmFZoww0gE9QZ92Y9fe_RohxLY3QYK1YgA3hpZQPq2qAhc4ofUOlWnx4EG3a2964Tctwe226fafplNI2z9NJ_d0_8zY9aBezZdqE_BxD4gghdVeDNKEv9yUVbjgW-7rjntyNn1F-GnHJ_DtAwgbH_5jkWfAqZ5C</recordid><startdate>201307</startdate><enddate>201307</enddate><creator>Utescu, Mihai S</creator><creator>Couture, Véronique</creator><creator>Mac-Way, Fabrice</creator><creator>De Serres, Sacha A</creator><creator>Marquis, Karine</creator><creator>Larivière, Richard</creator><creator>Desmeules, Simon</creator><creator>Lebel, Marcel</creator><creator>Boutouyrie, Pierre</creator><creator>Agharazii, Mohsen</creator><general>American Heart Association, Inc</general><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201307</creationdate><title>Determinants of Progression of Aortic Stiffness in Hemodialysis Patients: A Prospective Longitudinal Study</title><author>Utescu, Mihai S ; Couture, Véronique ; Mac-Way, Fabrice ; De Serres, Sacha A ; Marquis, Karine ; Larivière, Richard ; Desmeules, Simon ; Lebel, Marcel ; Boutouyrie, Pierre ; Agharazii, Mohsen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4010-3470c036c3cb8c435d5e3bbdd19ec42951e635fc5fe54d0da2eac6af44141be3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Aged</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Arterial hypertension. Arterial hypotension</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Cardiology. Vascular system</topic><topic>Cardiovascular Diseases - epidemiology</topic><topic>Cardiovascular Diseases - etiology</topic><topic>Cardiovascular Diseases - physiopathology</topic><topic>Disease Progression</topic><topic>Emergency and intensive care: renal failure. Dialysis management</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Incidence</topic><topic>Intensive care medicine</topic><topic>Kidney Failure, Chronic - therapy</topic><topic>Kidneys</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Nephropathies. Renovascular diseases. Renal failure</topic><topic>Prospective Studies</topic><topic>Quebec - epidemiology</topic><topic>Renal Dialysis - adverse effects</topic><topic>Renal failure</topic><topic>Risk Factors</topic><topic>Survival Rate - trends</topic><topic>Urinary system involvement in other diseases. Miscellaneous</topic><topic>Vascular Stiffness</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Utescu, Mihai S</creatorcontrib><creatorcontrib>Couture, Véronique</creatorcontrib><creatorcontrib>Mac-Way, Fabrice</creatorcontrib><creatorcontrib>De Serres, Sacha A</creatorcontrib><creatorcontrib>Marquis, Karine</creatorcontrib><creatorcontrib>Larivière, Richard</creatorcontrib><creatorcontrib>Desmeules, Simon</creatorcontrib><creatorcontrib>Lebel, Marcel</creatorcontrib><creatorcontrib>Boutouyrie, Pierre</creatorcontrib><creatorcontrib>Agharazii, Mohsen</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Hypertension (Dallas, Tex. 1979)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Utescu, Mihai S</au><au>Couture, Véronique</au><au>Mac-Way, Fabrice</au><au>De Serres, Sacha A</au><au>Marquis, Karine</au><au>Larivière, Richard</au><au>Desmeules, Simon</au><au>Lebel, Marcel</au><au>Boutouyrie, Pierre</au><au>Agharazii, Mohsen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Determinants of Progression of Aortic Stiffness in Hemodialysis Patients: A Prospective Longitudinal Study</atitle><jtitle>Hypertension (Dallas, Tex. 1979)</jtitle><addtitle>Hypertension</addtitle><date>2013-07</date><risdate>2013</risdate><volume>62</volume><issue>1</issue><spage>154</spage><epage>160</epage><pages>154-160</pages><issn>0194-911X</issn><eissn>1524-4563</eissn><coden>HPRTDN</coden><abstract>Aortic stiffness is associated with increased cardiovascular mortality in patients with chronic kidney disease. However, the rate of progression of arterial stiffness and the role of cardiovascular risk factors in the progression of arterial stiffness has never been established in a longitudinal study. In a prospective, longitudinal, observational study, carotid-femoral pulse wave velocity and carotid-radial pulse wave velocity were assessed in 109 hemodialysis patients at baseline and after a mean follow-up of 1.2 years. We examined the impact of age, atherosclerotic cardiovascular disease, diabetes mellitus, dialysis vintage, and pentosidine (a well-characterized, advanced glycation end products) on the rate of progression of aortic stiffness. The annual rate of changes in carotid-femoral pulse wave velocity and carotid-radial pulse wave velocity were 0.84 m/s per year (95% confidence interval, 0.50–1.12 m/s per year) and −0.66 m/s per year (95% confidence interval, −0.85 to −0.47 m/s per year), respectively. Older subjects, and patients with diabetes mellitus or atherosclerotic cardiovascular disease had higher aortic stiffness at baseline, however, the rate of progression of aortic stiffness was only determined by plasma pentosidine levels (P=0.001). The degree of baseline aortic stiffness was a significant determinant of the regression of brachial stiffness (P<0.001) suggesting that the regression of brachial stiffness occurs in response to central aortic stiffness. These findings suggest that traditional cardiovascular risk factors may play some role in the progression of aortic stiffness before development of advanced chronic kidney disease, and that the enhanced rate of progression of aortic stiffness in chronic kidney disease patients on dialysis are probably determined by more specific chronic kidney disease–related risk factors such as advanced-glycation end products.</abstract><cop>Hagerstown, MD</cop><pub>American Heart Association, Inc</pub><pmid>23648699</pmid><doi>10.1161/HYPERTENSIONAHA.113.01200</doi><tpages>7</tpages></addata></record> |
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| identifier | ISSN: 0194-911X |
| ispartof | Hypertension (Dallas, Tex. 1979), 2013-07, Vol.62 (1), p.154-160 |
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| source | MEDLINE; American Heart Association Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Journals@Ovid Complete |
| subjects | Aged Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Cardiovascular Diseases - epidemiology Cardiovascular Diseases - etiology Cardiovascular Diseases - physiopathology Disease Progression Emergency and intensive care: renal failure. Dialysis management Female Follow-Up Studies Humans Incidence Intensive care medicine Kidney Failure, Chronic - therapy Kidneys Male Medical sciences Middle Aged Nephrology. Urinary tract diseases Nephropathies. Renovascular diseases. Renal failure Prospective Studies Quebec - epidemiology Renal Dialysis - adverse effects Renal failure Risk Factors Survival Rate - trends Urinary system involvement in other diseases. Miscellaneous Vascular Stiffness |
| title | Determinants of Progression of Aortic Stiffness in Hemodialysis Patients: A Prospective Longitudinal Study |
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