Structure-Based Design of β‑Site APP Cleaving Enzyme 1 (BACE1) Inhibitors for the Treatment of Alzheimer’s Disease

The amyloid hypothesis asserts that excess production or reduced clearance of the amyloid-β (Aβ) peptides in the brain initiates a sequence of events that ultimately lead to Alzheimer’s disease and dementia. The Aβ hypothesis has identified BACE1 as a therapeutic target to treat Alzheimer’s and led...

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Veröffentlicht in:Journal of medicinal chemistry 2013-06, Vol.56 (11), p.4156-4180
Hauptverfasser: Yuan, Jing, Venkatraman, Shankar, Zheng, Yajun, McKeever, Brian M, Dillard, Lawrence W, Singh, Suresh B
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Sprache:eng
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