Increasing glucagon secretion could antagonize the action of exogenous insulin for glycemic control in streptozocin-induced diabetic rhesus monkeys

Although intraislet insulin signaling is known to play a critical role in regulating glucagon secretion, it is unknown whether abnormal glucagon secretion influences the hypoglycemic effect of exogenous insulin with intraislet insulin deletion. We performed a longitudinal study using 16 streptozocin...

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Veröffentlicht in:	Experimental biology and medicine (Maywood, N.J.) N.J.), 2013-04, Vol.238 (4), p.385-391
Hauptverfasser:	He, Sirong, Wang, Dan, Lu, Yanrong, Chen, Younan, Jin, Xi, Wang, Chengsi, Zhao, Jingming, Ren, Yan, Wang, Li, Li, Hongxia, Cheng, Jingqiu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood Glucose - metabolism Diabetes Mellitus, Experimental - chemically induced Diabetes Mellitus, Experimental - drug therapy Diabetes Mellitus, Experimental - metabolism Disease Models, Animal Dose-Response Relationship, Drug Glucagon - blood Glucagon-Secreting Cells - metabolism Glucagon-Secreting Cells - pathology Hypoglycemic Agents - pharmacology Hypoglycemic Agents - therapeutic use Insulin - pharmacology Insulin - therapeutic use Insulin Resistance - physiology Longitudinal Studies Macaca mulatta Streptozocin - adverse effects Time Factors Treatment Outcome Triglycerides - metabolism
Online-Zugang:	Volltext
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