Measuring corneal clouding in patients suffering from mucopolysaccharidosis with the Pentacam densitometry programme
Aim To identify a means to objectively measure corneal clouding in patients with mucopolysaccharidosis in a prospective controlled clinical trial. Methods Corneal haze was assessed by slit lamp examination and measured using the densitometry programme of the Pentacam, a rotating Scheimpflug camera i...
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| Veröffentlicht in: | British journal of ophthalmology 2013-07, Vol.97 (7), p.829-833 |
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| creator | Elflein, H M Hofherr, T Berisha-Ramadani, F Weyer, V Lampe, C Beck, M Pitz, S |
| description | Aim To identify a means to objectively measure corneal clouding in patients with mucopolysaccharidosis in a prospective controlled clinical trial. Methods Corneal haze was assessed by slit lamp examination and measured using the densitometry programme of the Pentacam, a rotating Scheimpflug camera in 33 mucopolysaccharidoses (MPS) patients and 32 controls. Results Pentacam measurements were available in 31 right and 31 left eyes of 32 patients and in 32 left and right eyes of 32 subjects in the control group. Slit lamp findings correlated very well with corneal density measurements (Spearman correlation right eye (OD)/left eye (OS)=0.782/0.791). MPS patients had higher density units (median OD/OS=14.1/14.7) than control subjects (median OD/OS=6.7/6.9, p |
| doi_str_mv | 10.1136/bjophthalmol-2012-302913 |
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Methods Corneal haze was assessed by slit lamp examination and measured using the densitometry programme of the Pentacam, a rotating Scheimpflug camera in 33 mucopolysaccharidoses (MPS) patients and 32 controls. Results Pentacam measurements were available in 31 right and 31 left eyes of 32 patients and in 32 left and right eyes of 32 subjects in the control group. Slit lamp findings correlated very well with corneal density measurements (Spearman correlation right eye (OD)/left eye (OS)=0.782/0.791). MPS patients had higher density units (median OD/OS=14.1/14.7) than control subjects (median OD/OS=6.7/6.9, p<0.001). In patients, the corneal centre density values (median OD/OS=13.8/14.0) did not differ from corneal periphery values (median OD/OS=14.3/14.7). Conclusions The densitometry programme of the Pentacam provides objective measurement of corneal haze in mucopolysaccharidosis patients.</description><identifier>ISSN: 0007-1161</identifier><identifier>EISSN: 1468-2079</identifier><identifier>DOI: 10.1136/bjophthalmol-2012-302913</identifier><identifier>PMID: 23685998</identifier><identifier>CODEN: BJOPAL</identifier><language>eng</language><publisher>BMA House, Tavistock Square, London, WC1H 9JR: BMJ Publishing Group Ltd</publisher><subject>Adolescent ; Adult ; Age ; Child ; Child, Preschool ; Cornea ; Corneal Opacity - classification ; Corneal Opacity - diagnosis ; Densitometry - instrumentation ; Diagnostic Techniques, Ophthalmological ; Diagnostic tests/Investigation ; Disease ; Enzymes ; Female ; Humans ; Male ; Middle Aged ; Mucopolysaccharidoses - classification ; Mucopolysaccharidoses - diagnosis ; Photography - instrumentation ; Prospective Studies ; Studies ; Visual Acuity - physiology ; Young Adult</subject><ispartof>British journal of ophthalmology, 2013-07, Vol.97 (7), p.829-833</ispartof><rights>Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions</rights><rights>Copyright: 2013 Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b425t-fe3f919db592e63b67efb83dd3c709c91650dbe3a685e248ffa5f75b25eb4ea33</citedby><cites>FETCH-LOGICAL-b425t-fe3f919db592e63b67efb83dd3c709c91650dbe3a685e248ffa5f75b25eb4ea33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttp://bjo.bmj.com/content/97/7/829.full.pdf$$EPDF$$P50$$Gbmj$$H</linktopdf><linktohtml>$$Uhttp://bjo.bmj.com/content/97/7/829.full$$EHTML$$P50$$Gbmj$$H</linktohtml><link.rule.ids>114,115,314,776,780,3183,23550,27901,27902,77342,77373</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23685998$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Elflein, H M</creatorcontrib><creatorcontrib>Hofherr, T</creatorcontrib><creatorcontrib>Berisha-Ramadani, F</creatorcontrib><creatorcontrib>Weyer, V</creatorcontrib><creatorcontrib>Lampe, C</creatorcontrib><creatorcontrib>Beck, M</creatorcontrib><creatorcontrib>Pitz, S</creatorcontrib><title>Measuring corneal clouding in patients suffering from mucopolysaccharidosis with the Pentacam densitometry programme</title><title>British journal of ophthalmology</title><addtitle>Br J Ophthalmol</addtitle><description>Aim To identify a means to objectively measure corneal clouding in patients with mucopolysaccharidosis in a prospective controlled clinical trial. Methods Corneal haze was assessed by slit lamp examination and measured using the densitometry programme of the Pentacam, a rotating Scheimpflug camera in 33 mucopolysaccharidoses (MPS) patients and 32 controls. Results Pentacam measurements were available in 31 right and 31 left eyes of 32 patients and in 32 left and right eyes of 32 subjects in the control group. Slit lamp findings correlated very well with corneal density measurements (Spearman correlation right eye (OD)/left eye (OS)=0.782/0.791). MPS patients had higher density units (median OD/OS=14.1/14.7) than control subjects (median OD/OS=6.7/6.9, p<0.001). In patients, the corneal centre density values (median OD/OS=13.8/14.0) did not differ from corneal periphery values (median OD/OS=14.3/14.7). Conclusions The densitometry programme of the Pentacam provides objective measurement of corneal haze in mucopolysaccharidosis patients.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Cornea</subject><subject>Corneal Opacity - classification</subject><subject>Corneal Opacity - diagnosis</subject><subject>Densitometry - instrumentation</subject><subject>Diagnostic Techniques, Ophthalmological</subject><subject>Diagnostic tests/Investigation</subject><subject>Disease</subject><subject>Enzymes</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mucopolysaccharidoses - classification</subject><subject>Mucopolysaccharidoses - diagnosis</subject><subject>Photography - instrumentation</subject><subject>Prospective Studies</subject><subject>Studies</subject><subject>Visual Acuity - physiology</subject><subject>Young Adult</subject><issn>0007-1161</issn><issn>1468-2079</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNkV2P1CAUhonRuLOrf8GQeONNtcAA5dJMXHWzrpP4cUtoe9gyllKBRuffy9h1Y7zyinB4Xs6BByFM6peEMPGqPYR5yIMZfRgrWhNasZoqwh6gDdmKppSkeog2dV3LihBBztB5SoeypYLIx-iMMtFwpZoNyh_ApCW66RZ3IU5gRtyNYelPBTfh2WQHU044LdbCb8zG4LFfujCH8ZhM1w0muj4kl_APlwecB8D7kjGd8biHKbkcPOR4xHMMt9F4D0_QI2vGBE_v1gv05fLN59276vrj2_e719dVu6U8VxaYVUT1LVcUBGuFBNs2rO9ZJ2vVKSJ43bfATHkM0G1jreFW8pZyaLdgGLtAL9Z7S-fvC6SsvUsdjKOZICxJl6-UjZSckoI-_wc9hCVOZTpNpGwUJ5KLQjUr1cWQUgSr5-i8iUdNan0yo_82o09m9GqmRJ_dNVhaD_198I-KAlQr4FKGn_fnJn7TQjLJ9c3Xnd7x_b75dCX0TeHZyrf-8P9j_AJP1LEu</recordid><startdate>201307</startdate><enddate>201307</enddate><creator>Elflein, H M</creator><creator>Hofherr, T</creator><creator>Berisha-Ramadani, F</creator><creator>Weyer, V</creator><creator>Lampe, C</creator><creator>Beck, M</creator><creator>Pitz, S</creator><general>BMJ Publishing Group Ltd</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>201307</creationdate><title>Measuring corneal clouding in patients suffering from mucopolysaccharidosis with the Pentacam densitometry programme</title><author>Elflein, H M ; Hofherr, T ; Berisha-Ramadani, F ; Weyer, V ; Lampe, C ; Beck, M ; Pitz, S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b425t-fe3f919db592e63b67efb83dd3c709c91650dbe3a685e248ffa5f75b25eb4ea33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Age</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Cornea</topic><topic>Corneal Opacity - classification</topic><topic>Corneal Opacity - diagnosis</topic><topic>Densitometry - instrumentation</topic><topic>Diagnostic Techniques, Ophthalmological</topic><topic>Diagnostic tests/Investigation</topic><topic>Disease</topic><topic>Enzymes</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mucopolysaccharidoses - classification</topic><topic>Mucopolysaccharidoses - diagnosis</topic><topic>Photography - instrumentation</topic><topic>Prospective Studies</topic><topic>Studies</topic><topic>Visual Acuity - physiology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Elflein, H M</creatorcontrib><creatorcontrib>Hofherr, T</creatorcontrib><creatorcontrib>Berisha-Ramadani, F</creatorcontrib><creatorcontrib>Weyer, V</creatorcontrib><creatorcontrib>Lampe, C</creatorcontrib><creatorcontrib>Beck, M</creatorcontrib><creatorcontrib>Pitz, S</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Elflein, H M</au><au>Hofherr, T</au><au>Berisha-Ramadani, F</au><au>Weyer, V</au><au>Lampe, C</au><au>Beck, M</au><au>Pitz, S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Measuring corneal clouding in patients suffering from mucopolysaccharidosis with the Pentacam densitometry programme</atitle><jtitle>British journal of ophthalmology</jtitle><addtitle>Br J Ophthalmol</addtitle><date>2013-07</date><risdate>2013</risdate><volume>97</volume><issue>7</issue><spage>829</spage><epage>833</epage><pages>829-833</pages><issn>0007-1161</issn><eissn>1468-2079</eissn><coden>BJOPAL</coden><abstract>Aim To identify a means to objectively measure corneal clouding in patients with mucopolysaccharidosis in a prospective controlled clinical trial. Methods Corneal haze was assessed by slit lamp examination and measured using the densitometry programme of the Pentacam, a rotating Scheimpflug camera in 33 mucopolysaccharidoses (MPS) patients and 32 controls. Results Pentacam measurements were available in 31 right and 31 left eyes of 32 patients and in 32 left and right eyes of 32 subjects in the control group. Slit lamp findings correlated very well with corneal density measurements (Spearman correlation right eye (OD)/left eye (OS)=0.782/0.791). MPS patients had higher density units (median OD/OS=14.1/14.7) than control subjects (median OD/OS=6.7/6.9, p<0.001). In patients, the corneal centre density values (median OD/OS=13.8/14.0) did not differ from corneal periphery values (median OD/OS=14.3/14.7). Conclusions The densitometry programme of the Pentacam provides objective measurement of corneal haze in mucopolysaccharidosis patients.</abstract><cop>BMA House, Tavistock Square, London, WC1H 9JR</cop><pub>BMJ Publishing Group Ltd</pub><pmid>23685998</pmid><doi>10.1136/bjophthalmol-2012-302913</doi><tpages>5</tpages></addata></record> |
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| subjects | Adolescent Adult Age Child Child, Preschool Cornea Corneal Opacity - classification Corneal Opacity - diagnosis Densitometry - instrumentation Diagnostic Techniques, Ophthalmological Diagnostic tests/Investigation Disease Enzymes Female Humans Male Middle Aged Mucopolysaccharidoses - classification Mucopolysaccharidoses - diagnosis Photography - instrumentation Prospective Studies Studies Visual Acuity - physiology Young Adult |
| title | Measuring corneal clouding in patients suffering from mucopolysaccharidosis with the Pentacam densitometry programme |
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