Growth pattern of tumor xenografts in wistar rats after treatment with cyclophosphamide, total lymphoid irradiation and/or cyclosporin A
Wistar rats treated with cyclophosphamide, total lymphoid irradiation (TLI and/or cyclosporin A (CSA) develop a state of immune suppression permitting the growth of tumor xenografts. Experiments were carried out on this newly developed model to investigate the growth patterns of a mouse osteosarcoma...
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| Veröffentlicht in: | International journal of radiation oncology, biology, physics biology, physics, 1983-01, Vol.9 (6), p.871-879 |
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| container_title | International journal of radiation oncology, biology, physics |
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| creator | Hoogenhout, J. Kazem, I. Jerusalem, C.R. Bakkeren, J.A.J. De Jong, J. Kal, H.B. Van Munster, P.J.J. |
| description | Wistar rats treated with cyclophosphamide, total lymphoid irradiation (TLI and/or cyclosporin A (CSA) develop a state of immune suppression permitting the growth of tumor xenografts. Experiments were carried out on this newly developed model to investigate the growth patterns of a mouse osteosarcoma and a human colon adenocarcinoma. The combination of cyclophosphamide and CSA permitted a limited period of growth of the mouse osteosarcoma with a tumor take rate of 66%. No takes were observed with the human adenocarcinoma. The combination of cyclophosphamide and TLI resulted in a period of immunosuppression followed by recovery of the immune status. During the period of immunosuppression, tumor xenografts showed a 100% take rate. The most efficient immunosuppression was achieved by a combination of cyclophosphamide, TLI and CSA administered on alternate days. Wistar rats subjected to this treatment showed prolonged tolerance to mouse osteosarcoma and human adenocarcinoma xenografts. There was no alteration in the tumor doubling time or histological morphology of the xenografts in the adapted host as compared with those in the donor tumors. The tumor growth curve showed a pattern of of initial growth, a period of stagnation, followed by a steady but slower growth phase. The significance of the results and the advantages of the rat model described in this paper for human tumor xenotransplantation are discussed. |
| doi_str_mv | 10.1016/0360-3016(83)90014-7 |
| format | Article |
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Experiments were carried out on this newly developed model to investigate the growth patterns of a mouse osteosarcoma and a human colon adenocarcinoma. The combination of cyclophosphamide and CSA permitted a limited period of growth of the mouse osteosarcoma with a tumor take rate of 66%. No takes were observed with the human adenocarcinoma. The combination of cyclophosphamide and TLI resulted in a period of immunosuppression followed by recovery of the immune status. During the period of immunosuppression, tumor xenografts showed a 100% take rate. The most efficient immunosuppression was achieved by a combination of cyclophosphamide, TLI and CSA administered on alternate days. Wistar rats subjected to this treatment showed prolonged tolerance to mouse osteosarcoma and human adenocarcinoma xenografts. There was no alteration in the tumor doubling time or histological morphology of the xenografts in the adapted host as compared with those in the donor tumors. The tumor growth curve showed a pattern of of initial growth, a period of stagnation, followed by a steady but slower growth phase. The significance of the results and the advantages of the rat model described in this paper for human tumor xenotransplantation are discussed.</description><identifier>ISSN: 0360-3016</identifier><identifier>EISSN: 1879-355X</identifier><identifier>DOI: 10.1016/0360-3016(83)90014-7</identifier><identifier>PMID: 6575007</identifier><identifier>CODEN: IOBPD3</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adenocarcinoma - immunology ; Animals ; Biological and medical sciences ; Colonic Neoplasms - immunology ; Cyclophosphamide ; Cyclophosphamide - pharmacology ; cyclosporin A ; Cyclosporins - pharmacology ; Human adenocarcinoma ; Humans ; Immunosuppression ; Immunosuppressive Agents - pharmacology ; Lymphoid Tissue - radiation effects ; Medical sciences ; Mice ; Mouse osteosarcoma C 22LR ; Neoplasm Transplantation ; Neoplasms - immunology ; Neoplasms, Experimental - immunology ; Osteosarcoma - immunology ; Rats ; Total lymphoid irradiation ; Transplantability ; Transplantation Immunology - drug effects ; Transplantation Immunology - radiation effects ; Transplantation, Heterologous ; Tumor cell ; Tumor xenograft ; Tumors ; Wistar rat</subject><ispartof>International journal of radiation oncology, biology, physics, 1983-01, Vol.9 (6), p.871-879</ispartof><rights>1983</rights><rights>1984 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-dac5df2a3e6e3926f048c6240ba41a2f2c96bbfdff5f8dd4bb96c97d0fc7c3f3</citedby><cites>FETCH-LOGICAL-c417t-dac5df2a3e6e3926f048c6240ba41a2f2c96bbfdff5f8dd4bb96c97d0fc7c3f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0360301683900147$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9363319$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6575007$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hoogenhout, J.</creatorcontrib><creatorcontrib>Kazem, I.</creatorcontrib><creatorcontrib>Jerusalem, C.R.</creatorcontrib><creatorcontrib>Bakkeren, J.A.J.</creatorcontrib><creatorcontrib>De Jong, J.</creatorcontrib><creatorcontrib>Kal, H.B.</creatorcontrib><creatorcontrib>Van Munster, P.J.J.</creatorcontrib><title>Growth pattern of tumor xenografts in wistar rats after treatment with cyclophosphamide, total lymphoid irradiation and/or cyclosporin A</title><title>International journal of radiation oncology, biology, physics</title><addtitle>Int J Radiat Oncol Biol Phys</addtitle><description>Wistar rats treated with cyclophosphamide, total lymphoid irradiation (TLI and/or cyclosporin A (CSA) develop a state of immune suppression permitting the growth of tumor xenografts. Experiments were carried out on this newly developed model to investigate the growth patterns of a mouse osteosarcoma and a human colon adenocarcinoma. The combination of cyclophosphamide and CSA permitted a limited period of growth of the mouse osteosarcoma with a tumor take rate of 66%. No takes were observed with the human adenocarcinoma. The combination of cyclophosphamide and TLI resulted in a period of immunosuppression followed by recovery of the immune status. During the period of immunosuppression, tumor xenografts showed a 100% take rate. The most efficient immunosuppression was achieved by a combination of cyclophosphamide, TLI and CSA administered on alternate days. Wistar rats subjected to this treatment showed prolonged tolerance to mouse osteosarcoma and human adenocarcinoma xenografts. There was no alteration in the tumor doubling time or histological morphology of the xenografts in the adapted host as compared with those in the donor tumors. The tumor growth curve showed a pattern of of initial growth, a period of stagnation, followed by a steady but slower growth phase. The significance of the results and the advantages of the rat model described in this paper for human tumor xenotransplantation are discussed.</description><subject>Adenocarcinoma - immunology</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Colonic Neoplasms - immunology</subject><subject>Cyclophosphamide</subject><subject>Cyclophosphamide - pharmacology</subject><subject>cyclosporin A</subject><subject>Cyclosporins - pharmacology</subject><subject>Human adenocarcinoma</subject><subject>Humans</subject><subject>Immunosuppression</subject><subject>Immunosuppressive Agents - pharmacology</subject><subject>Lymphoid Tissue - radiation effects</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mouse osteosarcoma C 22LR</subject><subject>Neoplasm Transplantation</subject><subject>Neoplasms - immunology</subject><subject>Neoplasms, Experimental - immunology</subject><subject>Osteosarcoma - immunology</subject><subject>Rats</subject><subject>Total lymphoid irradiation</subject><subject>Transplantability</subject><subject>Transplantation Immunology - drug effects</subject><subject>Transplantation Immunology - radiation effects</subject><subject>Transplantation, Heterologous</subject><subject>Tumor cell</subject><subject>Tumor xenograft</subject><subject>Tumors</subject><subject>Wistar rat</subject><issn>0360-3016</issn><issn>1879-355X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMFu1DAURS0EKtPCH4DkBUIgkdaOEzvZIFVVaZEqddMFO-vFfmaMkjjYHsr8AZ-NpzOaZVe23733XesQ8o6zc864vGBCskqU26dOfO4Z402lXpAV71Rfibb98ZKsjpbX5DSlX6yYuGpOyIlsVcuYWpF_NzE85jVdIGeMMw2O5s0UIv2Lc_gZweVE_UwffcoQaYTyLDOMNEeEPOGci1byZmvGsKxDWtYweYtfaA4ZRjpupzL1lvoYwXrIPswUZntRKp4yaQmxFFy-Ia8cjAnfHs4z8vDt-uHqtrq7v_l-dXlXmYarXFkwrXU1CJQo-lo61nRG1g0boOFQu9r0chicda51nbXNMPTS9MoyZ5QRTpyRj_u1Swy_N5iynnwyOI4wY9gkzYVUSnV9MTZ7o4khpYhOL9FPELeaM73jr3dw9Q6u7oR-4q9Vib0_7N8ME9pj6AC86B8OOiQDo4swG5-Otl5IIfiu_evehgXFH49RJ-NxNmh9RJO1Df75f_wHmkGmCA</recordid><startdate>19830101</startdate><enddate>19830101</enddate><creator>Hoogenhout, J.</creator><creator>Kazem, I.</creator><creator>Jerusalem, C.R.</creator><creator>Bakkeren, J.A.J.</creator><creator>De Jong, J.</creator><creator>Kal, H.B.</creator><creator>Van Munster, P.J.J.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>19830101</creationdate><title>Growth pattern of tumor xenografts in wistar rats after treatment with cyclophosphamide, total lymphoid irradiation and/or cyclosporin A</title><author>Hoogenhout, J. ; Kazem, I. ; Jerusalem, C.R. ; Bakkeren, J.A.J. ; De Jong, J. ; Kal, H.B. ; Van Munster, P.J.J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-dac5df2a3e6e3926f048c6240ba41a2f2c96bbfdff5f8dd4bb96c97d0fc7c3f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Adenocarcinoma - immunology</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Colonic Neoplasms - immunology</topic><topic>Cyclophosphamide</topic><topic>Cyclophosphamide - pharmacology</topic><topic>cyclosporin A</topic><topic>Cyclosporins - pharmacology</topic><topic>Human adenocarcinoma</topic><topic>Humans</topic><topic>Immunosuppression</topic><topic>Immunosuppressive Agents - pharmacology</topic><topic>Lymphoid Tissue - radiation effects</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mouse osteosarcoma C 22LR</topic><topic>Neoplasm Transplantation</topic><topic>Neoplasms - immunology</topic><topic>Neoplasms, Experimental - immunology</topic><topic>Osteosarcoma - immunology</topic><topic>Rats</topic><topic>Total lymphoid irradiation</topic><topic>Transplantability</topic><topic>Transplantation Immunology - drug effects</topic><topic>Transplantation Immunology - radiation effects</topic><topic>Transplantation, Heterologous</topic><topic>Tumor cell</topic><topic>Tumor xenograft</topic><topic>Tumors</topic><topic>Wistar rat</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hoogenhout, J.</creatorcontrib><creatorcontrib>Kazem, I.</creatorcontrib><creatorcontrib>Jerusalem, C.R.</creatorcontrib><creatorcontrib>Bakkeren, J.A.J.</creatorcontrib><creatorcontrib>De Jong, J.</creatorcontrib><creatorcontrib>Kal, H.B.</creatorcontrib><creatorcontrib>Van Munster, P.J.J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>International journal of radiation oncology, biology, physics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hoogenhout, J.</au><au>Kazem, I.</au><au>Jerusalem, C.R.</au><au>Bakkeren, J.A.J.</au><au>De Jong, J.</au><au>Kal, H.B.</au><au>Van Munster, P.J.J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Growth pattern of tumor xenografts in wistar rats after treatment with cyclophosphamide, total lymphoid irradiation and/or cyclosporin A</atitle><jtitle>International journal of radiation oncology, biology, physics</jtitle><addtitle>Int J Radiat Oncol Biol Phys</addtitle><date>1983-01-01</date><risdate>1983</risdate><volume>9</volume><issue>6</issue><spage>871</spage><epage>879</epage><pages>871-879</pages><issn>0360-3016</issn><eissn>1879-355X</eissn><coden>IOBPD3</coden><abstract>Wistar rats treated with cyclophosphamide, total lymphoid irradiation (TLI and/or cyclosporin A (CSA) develop a state of immune suppression permitting the growth of tumor xenografts. Experiments were carried out on this newly developed model to investigate the growth patterns of a mouse osteosarcoma and a human colon adenocarcinoma. The combination of cyclophosphamide and CSA permitted a limited period of growth of the mouse osteosarcoma with a tumor take rate of 66%. No takes were observed with the human adenocarcinoma. The combination of cyclophosphamide and TLI resulted in a period of immunosuppression followed by recovery of the immune status. During the period of immunosuppression, tumor xenografts showed a 100% take rate. The most efficient immunosuppression was achieved by a combination of cyclophosphamide, TLI and CSA administered on alternate days. Wistar rats subjected to this treatment showed prolonged tolerance to mouse osteosarcoma and human adenocarcinoma xenografts. There was no alteration in the tumor doubling time or histological morphology of the xenografts in the adapted host as compared with those in the donor tumors. The tumor growth curve showed a pattern of of initial growth, a period of stagnation, followed by a steady but slower growth phase. The significance of the results and the advantages of the rat model described in this paper for human tumor xenotransplantation are discussed.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>6575007</pmid><doi>10.1016/0360-3016(83)90014-7</doi><tpages>9</tpages></addata></record> |
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| identifier | ISSN: 0360-3016 |
| ispartof | International journal of radiation oncology, biology, physics, 1983-01, Vol.9 (6), p.871-879 |
| issn | 0360-3016 1879-355X |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adenocarcinoma - immunology Animals Biological and medical sciences Colonic Neoplasms - immunology Cyclophosphamide Cyclophosphamide - pharmacology cyclosporin A Cyclosporins - pharmacology Human adenocarcinoma Humans Immunosuppression Immunosuppressive Agents - pharmacology Lymphoid Tissue - radiation effects Medical sciences Mice Mouse osteosarcoma C 22LR Neoplasm Transplantation Neoplasms - immunology Neoplasms, Experimental - immunology Osteosarcoma - immunology Rats Total lymphoid irradiation Transplantability Transplantation Immunology - drug effects Transplantation Immunology - radiation effects Transplantation, Heterologous Tumor cell Tumor xenograft Tumors Wistar rat |
| title | Growth pattern of tumor xenografts in wistar rats after treatment with cyclophosphamide, total lymphoid irradiation and/or cyclosporin A |
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