Development and validation of highly selective and robust method for simultaneous estimation of pioglitazone, hydroxypioglitazone and metformin in human plasma by LC–MS/MS: Application to a pharmacokinetic study

•Robust single method for distantly polar compounds in human plasma by LC–MS/MS.•Simple economic precipitation extraction procedure with low sample volume.•Labeled internal standards to track the analytes suitably.•Rapid analysis turnaround time for pharmacokinetic studies.•Negligible matrix interfe...

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Veröffentlicht in:	Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Analytical technologies in the biomedical and life sciences, 2013-07, Vol.930, p.136-145
Hauptverfasser:	Jagadeesh, B., Bharathi, D. Vijaya, Pankaj, C., Narayana, V. Satya, Venkateswarulu, V.
Format:	Artikel
Sprache:	eng
Schlagworte:	chromatography Chromatography, Liquid - methods Drug Stability Human plasma Humans Hydroxypioglitazone LC–MS/MS Male metabolites Metformin Metformin - blood Metformin - chemistry Metformin - pharmacokinetics monitoring Pharmacokinetics Pioglitazone Reproducibility of Results Sensitivity and Specificity tandem mass spectrometry Tandem Mass Spectrometry - methods Thiazolidinediones - blood Thiazolidinediones - chemistry Thiazolidinediones - pharmacokinetics
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