Development and Validation of an Enzyme Linked Immunosorbent Assay for Palivizumab Serum Determination

Palivizumab (Synagis®) is a humanized monoclonal antibody (IgG1K) composed of 95% human and 5% murine sequences. It is directed to an epitope in the A antigenic site of the F protein of respiratory syncytial virus (RSV). Palivizumab is used for prevention of serious lower respiratory tract disease c...

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Veröffentlicht in:	International journal of immunopathology and pharmacology 2013-04, Vol.26 (2), p.503-510
Hauptverfasser:	Montagna, M., Visai, L., Di Comite, A., Iommiello, V., Avanzini, M.A., Bloise, N., Stronati, M., Regazzi, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Monoclonal, Humanized - administration & dosage Antibodies, Monoclonal, Humanized - blood Antiviral Agents - administration & dosage Antiviral Agents - blood Calibration Drug Monitoring - methods Drug Monitoring - standards Enzyme-Linked Immunosorbent Assay - standards Humans Infant Injections, Intramuscular Limit of Detection Linear Models Observer Variation Palivizumab Reference Standards Reproducibility of Results Sensitivity and Specificity
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