Asymmetric dimethylarginine regulates the lipopolysaccharide-induced nitric oxide production in macrophages by suppressing the activation of NF-kappaB and iNOS expression

Two major effector systems are frequently implicated in the immune and endothelial cell alternations associated with inflammation. They include the enhanced production of reactive oxygen species and diminished bioavailability of nitric oxide (NO). Importantly, these processes can be regulated by end...

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Veröffentlicht in:	European journal of pharmacology 2013-08, Vol.713 (1-3), p.68-77
Hauptverfasser:	Pekarova, Michaela, Kubala, Lukas, Martiskova, Hana, Bino, Lucia, Twarogova, Michaela, Klinke, Anna, Rudolph, Tanja K., Kuchtova, Zdenka, Kolarova, Hana, Ambrozova, Gabriela, Kuchta, Radek, Kadlec, Jaroslav, Lojek, Antonin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arginine - analogs & derivatives Arginine - chemistry Arginine - pharmacology Asymmetric dimethylarginine bioavailability Blotting, Western Cell Culture Techniques Cell Line Cell Survival - drug effects Dose-Response Relationship, Drug endothelial cells gene expression Gene Expression - drug effects gene expression regulation Gram-negative bacteria Inducible nitric oxide synthase inflammation lipopolysaccharides Lipopolysaccharides - toxicity Macrophage macrophage activation macrophages Macrophages, Alveolar - drug effects Macrophages, Alveolar - immunology Macrophages, Alveolar - metabolism Macrophages, Peritoneal - drug effects Macrophages, Peritoneal - immunology Macrophages, Peritoneal - metabolism messenger RNA Methylarginine Mice NF-kappa B - antagonists & inhibitors NF-kappa B - biosynthesis NF-kappa B - genetics Nitric oxide Nitric Oxide - biosynthesis Nitric Oxide Synthase Type II - antagonists & inhibitors Nitric Oxide Synthase Type II - biosynthesis Nitric Oxide Synthase Type II - genetics pharmacology reactive oxygen species Reverse Transcriptase Polymerase Chain Reaction signal transduction Superoxides - metabolism Symmetric dimethylarginine transcription factor NF-kappa B
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