Peripheral antinociceptive efficacy and potency of a novel opioid compound 14-O-MeM6SU in comparison to known peptide and non-peptide opioid agonists in a rat model of inflammatory pain

This study compared the peripheral analgesic effects of a novel opioid agonist 14-O-methylmorphine-6-O-sulfate (14-O-MeM6SU), to that of non-peptide (morphine, fentanyl) and peptide opioid agonists (Met-enkephalin; met-ENK and β-endorphin; β-END) in a model of localized inflammatory pain evoked by i...

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Veröffentlicht in:	European journal of pharmacology 2013-08, Vol.713 (1-3), p.54-57
Hauptverfasser:	Khalefa, Baled. I., Mousa, Shaaban A., Shaqura, Mohammed, Lackó, Erzsébet, Hosztafi, Sándor, Riba, Pál, Schäfer, Michael, Ferdinandy, Péter, Fürst, Susanna, Al-Khrasani, Mahmoud
Format:	Artikel
Sprache:	eng
Schlagworte:	14-O-MeM6SU agonists Analgesia analgesic effect Analgesics, Opioid - chemistry Analgesics, Opioid - therapeutic use animal models Animals antagonists bioassays Codeine - analogs & derivatives Codeine - chemistry Codeine - therapeutic use Disease Models, Animal Dose-Response Relationship, Drug fentanyl Inflammatory pain Male morphine Morphine Derivatives - administration & dosage Morphine Derivatives - chemistry Morphine Derivatives - therapeutic use Muscle Contraction - drug effects Nociceptive Pain - drug therapy Nociceptive Pain - metabolism Opioid agonist efficacy opioid peptides Opioid Peptides - administration & dosage Opioid Peptides - chemistry Opioid Peptides - therapeutic use pain Peripheral opioid receptor pharmacokinetics Rats Rats, Wistar Receptors, Opioid - agonists Vas Deferens - drug effects Vas Deferens - metabolism
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