The essential comet assay: a comprehensive guide to measuring DNA damage and repair

The comet assay (single cell gel electrophoresis) is the most common method for measuring DNA damage in eukaryotic cells or disaggregated tissues. The assay depends on the relaxation of supercoiled DNA in agarose-embedded nucleoids (the residual bodies remaining after lysis of cells with detergent a...

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Veröffentlicht in:	Archives of toxicology 2013-06, Vol.87 (6), p.949-968
Hauptverfasser:	Azqueta, Amaya, Collins, Andrew R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anodes Bioassays Biomedical and Life Sciences Biomedicine Cell Survival - drug effects Comet Assay - methods DNA Damage DNA Methylation - drug effects DNA repair DNA Repair - drug effects Dose-Response Relationship, Drug Environmental Health Environmental Monitoring - methods Genetic Markers High-Throughput Screening Assays - methods Humans Microscopy, Fluorescence Occupational Medicine/Industrial Medicine Pharmacology/Toxicology Reproducibility of Results Review Article Risk Assessment Toxicity Toxicology
Online-Zugang:	Volltext
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